Results 61 to 70 of about 795,232 (125)

Unilateral Hormonally Active Testicular Sertoli Cell Tumour and Feminization Syndrome in a Bernese Mountain Dog With Normally Descended Testes

Reproduction in Domestic Animals, Volume 61, Issue 11, November 2026.
ABSTRACT To describe the clinical presentation, diagnostic workup and successful outcome of a hormonally active testicular Sertoli cell tumour (SCT) in a non‐cryptorchid Bernese Mountain Dog. A 10‐year‐old intact male dog was evaluated with a history of progressive alopecia, gynaecomastia and haematuria.
Ariu Federica, Burrai Giovanni Pietro, Cubeddu Francesca, Masala Gerolamo, Moalli Marzia, Antuofermo Elisabetta, Corda Francesca, Pinna Parpaglia Maria Luisa, Corda Andrea   +8 more
wiley   +1 more source

Annual frequency of canine mammary tumors according to the tissue of origin (2002–2012).

, 2015
a,b,c For benign or malignant neoplasm, uncommon superscript between tissue origin indicates differences at p < 0.001.Annual frequency of canine mammary tumors according to the tissue of origin (2002–2012).
Adelys Márquez (740958), Yaritza Salas (740957), Daniel Diaz (4677346), Laura Romero (740959)   +3 more
core   +1 more source

Immunohistochemical Analysis of Inter-Alpha-Trypsin Inhibitor Heavy Chain 2 and Enolase 1 in Canine Mammary Tumors: Associations with Tumor Aggressiveness and Prognostic Significance

Veterinary Sciences
Mammary neoplasms in dogs are a common clinical concern, especially in middle-aged and older intact females. These tumors share similarities with human breast cancer in terms of histology, disease progression, and risk factors, making dogs a relevant ...
Luadna dos Santos e Silva, Pedro Henrique Fogaça Jordão, Beatriz Castilho Balieiro, Laura de Souza Baracioli, Daniela Farias de Nóbrega, Adriana Alonso Novais, Luiz Gustavo de Almeida Chuffa, Debora Aparecida Pires de Campos Zuccari   +7 more
doaj   +1 more source

Synthesis and Biological Evaluation of a Lipophilic Vorinostat Prodrug

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A series of lipid‐vorinostat conjugates (3a‐d) through acylation with short‐chain fatty acid chloride derivatives were synthesized. The compound 3d demonstrated improved cytotoxicity against A549 and 4T1 carcinoma cells. Mechanistic insight revealed that the prodrug 3d induced higher levels of caspase‐3/7 activation, reactive oxygen species (ROS), and ...
Navneet Thakur, Neha Bhardwaj, Sudesh Kumar Yadav, Ankit Saneja   +3 more
wiley   +1 more source

Doxorubicin as a Potential Treatment Option in Canine Mammary Tumors

, 2023
Canine mammary tumors represent one of the leading malignant pathologies in female dogs, displaying the importance of efficient therapeutic findings, besides the golden-standard surgery, able to limit the development of the disease.
Liviuta Budisan, Oana Zanoaga, Madalina Luciana Gherman, Ioana Berindan-Neagoe, Lajos Raduly   +4 more
core   +1 more source

Exploring Neutrophil Extracellular Traps in Canine Soft Tissue Sarcomas: A Preliminary Study With Translational Insights

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Neutrophil Extracellular Traps (NETs) in Canine Soft Tissue Sarcomas This study investigated the presence of neutrophil extracellular traps (NETs) in canine soft tissue sarcomas using dual immunohistochemistry for citrullinated histone‐3 and myeloperoxidase.
Burak Yildirim, Volkan Ipek
wiley   +1 more source

Transcriptomic Profiling of Canine Mammary Tumours Reveals Significant Heterogeneity Between and Within Histological Classes

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 444-457, September 2026.
ABSTRACT This study presents a comprehensive transcriptomic analysis of 128 canine mammary tumours (CMTs), aiming to characterize their molecular landscape. Differential gene expression analysis (DGE), gene set enrichment analysis (GSEA) and clustering based on the human PAM50 gene panel were applied to explore molecular differences between the ...
Ingrid Marie Moberg, Nina Hansen, Helga Bergholtz, Kaja Sverdrup Borge, Gjermund Gunnes, Ellen Frøysadal Arnet, Ole Albert Guttersrud, Monica Hongrø Solbakken, Frode Lingaas   +8 more
wiley   +1 more source

413 The epithelial–mesenchymal transition protects heterogeneous breast tumors against immune attack in multiple species

Journal of Clinical and Translational Science
Objectives/Goals: Our aim was to identify how the epithelial–mesenchymal transition shields heterogeneous breast tumors against immune attack. Additionally, we endeavored to understand whether our findings were conserved in canine mammary tumors as a ...
Kimaya Bakhle, Shiney Chandraganti, Brian Feng, Brenda Ramos-Villanueva, Andrew Miller   +4 more
doaj   +1 more source

Transcriptomic and microRNA Profiling Suggest a Candidate RIPPLY1–cfa‐miR‐187 Relationship in Canine Mammary Gland Tumours From Dogs With Confirmed Metastasis

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 631-642, September 2026.
ABSTRACT Canine mammary gland tumours (MGT) represent a common malignancy in intact female dogs, with a high metastasis rate approaching 50% and a poor prognosis. However, metastasis‐related genes remain largely unelucidated. Accordingly, we aimed to identify differentially expressed mRNAs and miRNAs in primary canine MGT tissues from dogs with or ...
Shaohsu Wang, Masashi Takahashi, Hui‐Wen Chen, Nobuhiro Nozaki, Mohammad Arif, Yutaro Ide, Yoshiyuki Akiyama, Sirazul Islam, Tatsuro Hifumi, Shinji Hirano, Noriaki Miyoshi, Osamu Yamato, Daiki Kato, Takayuki Nakagawa, Naoki Miura   +14 more
wiley   +1 more source

Stat3 expression in canine mammary gland tumors and mammary gland hyperplasia

, 2001
Aim of this study was to detect by immunohistochemical methods STAT3 expression in canine mammary tumors and in canine mammary gland hyperplasia. Moderate to intense STAT3 protein labelling was detected in all epithlial neoplastic cells in canine mammary
PETTERINO, CLAUDIO, CASTAGNARO, MASSIMO, MARTINI, MARCO   +2 more
core