Results 81 to 90 of about 74,377 (332)

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Hauer, Daniela, Kilger, Erich, Schelling, Gustav, Schopp, Mirjam, Strewe, Claudia, Toth, Roland, Weis, Florian   +9 more
core   +1 more source

Cannabinoid receptor type-1: breaking the dogmas [version 1; referees: 3 approved]

F1000Research, 2016
The endocannabinoid system (ECS) is abundantly expressed in the brain. This system regulates a plethora of physiological functions and is composed of cannabinoid receptors, their endogenous ligands (endocannabinoids), and the enzymes involved in the ...
Arnau Busquets Garcia, Edgar Soria-Gomez, Luigi Bellocchio, Giovanni Marsicano   +3 more
doaj   +1 more source

Type 2 Diabetes Alters Vascular Cannabinoid Receptor 1 Expression, Phosphorylation Status, and Vasorelaxation in Rat Aorta

Molecules, 2020
Previous studies have suggested a role of the endocannabinoid system in metabolic diseases, such as diabetes. We investigated the effect of diabetes on cannabinoid receptor type 1 (CB1) expression and cannabinoid-induced vasorelaxation in rat aorta rings.
Enrique Sánchez-Pastor, Xóchitl Trujillo, Christian Ramos-Flores, Mónica Ríos-Silva, Felipa Andrade, Yolitzy Cárdenas, Elena Castro, Zorayda Urzúa, Oscar Newton-Sánchez, Miguel Huerta   +9 more
doaj   +1 more source

Involvement of cannabinoid receptors in depression of the putative nociceptive response in spinal cord preparations isolated from neonatal rats

Journal of Physiological Sciences, 2023
A metabolite of acetaminophen, AM404, which is an anandamide transporter inhibitor, induces analgesia mainly via activation of transient receptor potential channel 1 in the spinal cord, although the role of cannabinoid receptors remains to be studied ...
Kayo Tsuzawa, Hiroshi Onimaru, Katsunori Inagaki, Masahiko Izumizaki   +3 more
doaj   +1 more source

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse [PDF]

, 2019
In the isolated rat carotid artery, the endocannabinoid anandamide induces endothelium-dependent relaxation via activation of the enzyme sphingosine kinase (SK).
Alganga, Husam, Ballantyne, Margaret D., Ewart, Marie-Ann, Fertig, Bracy, Greig, Fiona H., Kazi, Zeshan H., Kennedy, Simon, Nather, Katrin, Pyne, Nigel J., Pyne, Susan, Zaborska, Karolina E.   +10 more
core   +2 more sources

Long‐Term Follow‐Up of Patients with Mass Social Media‐Induced Illness Presenting with Functional Tic‐like Behaviors

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Only little is known about the prognosis of functional tic‐like behaviors (FTLB), especially in the subgroup of patients with mass social media‐induced illness (MSMI‐FTLB). Objectives To provide data of long‐term follow‐up (FU) of a carefully characterized group of patients with MSMI‐FTLB to identify influencing factors such as ...
L. Kathrin Hartung, Simon Schmitt, Carolin Fremer, Carolin S. Klages, Natalia Szejko, Kirsten R. Müller‐Vahl   +5 more
wiley   +1 more source

A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis [PDF]

, 2019
Background: Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin ...
Barbierato, M., Contarini, G., Facci, L., Franceschini, D., Giusti, P., Zusso, M.   +5 more
core   +1 more source

Bridging the Regulatory Chasm in Investigator‐Initiated Human Subject Cannabis Research

Clinical Pharmacology &Therapeutics, EarlyView.
Heather M. Barkholtz, William Naviaux
wiley   +1 more source

Exploration of the Phytochemical and Antidiabetic Properties of Teucrium polium: A Natural Asset for Type 2 Diabetes Management

ChemistryOpen, EarlyView.
Teucrium polium shows antidiabetic activity with its phytochemical composition and biological activities. The essential oil is rich in carvacrol, thymol, γ‐terpinene, and o‐cymene, while the aqueous and hydroethanolic extracts are characterized by poliumoside, verbascoside, isorhamnetin‐3‐O‐rutinoside, and apigenin‐7‐rutinoside. Antioxidant activity is
Hajar El Ouadni, Aziz Drioiche, Fadoua El Makhoukhi, Omkulthom Al kamaly, Hannou Zerkani, Smail Amalich, Imane Tagnaout, Mohamed Radi, Yahya Cherrah, Touriya Zair, Katim Alaoui   +10 more
wiley   +1 more source

Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice [PDF]

, 2019
Background With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects.
Boehm, Stephen L., II, Lapish, Christopher C., Mackie, Ken, Smoker, Michael P.   +3 more
core   +2 more sources