Results 171 to 180 of about 5,591 (212)

Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes. [PDF]

Pharmaceuticals (Basel)
Alfieri A, Di Franco S, Maffei V, Sansone P, Pace MC, Passavanti MB, Fiore M.   +6 more
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Selective cannabinoid receptor 2 modulators: a patent review 2009 – present

Expert Opinion on Therapeutic Patents, 2012
The activation of the cannabinoid receptor 2 (CB2) affects a myriad of immune responses from inflammation to neuroprotection, demonstrates analgesic effects and suppresses responses in many animal models of pain. Questions around the involvement of CB1 activation in these effects remain, but efforts have been directed toward the discovery of highly ...
Doris Riether
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GABAA receptors modulate cannabinoid-evoked hypothermia

Pharmacology Biochemistry and Behavior, 2004
Cannabinoids evoke hypothermia by stimulating central CB(1) receptors. GABA induces hypothermia via GABA(A) or GABA(B) receptor activation. CB(1) receptor activation increases GABA release in the hypothalamus, a central locus for thermoregulation, suggesting that cannabinoid and GABA systems may be functionally linked in body temperature regulation. We
S M, Rawls, R J, Tallarida, D A, Kon, E B, Geller, Martin W, Adler   +4 more
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Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor

ACS Chemical Neuroscience, 2017
The cannabinoid 1 receptor (CB1R) is one of the most widely expressed metabotropic G protein-coupled receptors in brain, and its participation in various (patho)physiological processes has made CB1R activation a viable therapeutic modality. Adverse psychotropic effects limit the clinical utility of CB1R orthosteric agonists and have promoted the search
Robert B. Laprairie, Pushkar M. Kulkarni, Jeffrey R. Deschamps, Melanie E. M. Kelly, David R. Janero, Maria G. Cascio, Lesley A. Stevenson, Roger G. Pertwee, Terrence P. Kenakin, Eileen M. Denovan-Wright, Ganesh A. Thakur   +10 more
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C-3 Amido-Indole cannabinoid receptor modulators

Bioorganic & Medicinal Chemistry Letters, 2002
C-3 Amido-indoles were found to selectively bind to the CB2 receptor. SAR studies led to optimized compounds with excellent in vivo potency against LPS induced TNF-alpha release in murine models of cytokine production.
John, Hynes, Katerina, Leftheris, Hong, Wu, Chennagiri, Pandit, Ping, Chen, Derek J, Norris, Bang-Chi, Chen, Rulin, Zhao, Peter A, Kiener, Xiaorong, Chen, Lori A, Turk, Vina, Patil-Koota, Kathleen M, Gillooly, David J, Shuster, Kim W, McIntyre   +14 more
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Allosteric Modulation of the Cannabinoid CB1 Receptor

Molecular Pharmacology, 2005
We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), Org 27759 (3-ethyl-5-fluoro-1H-indole-2-carboxylic acid [2-94-dimethylamino-phenyl)-ethyl]-amide), and Org 29647 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid (1-benzyl-pyrrolidin-3-yl)-amide, 2 ...
Martin R, Price, Gemma L, Baillie, Adèle, Thomas, Lesley A, Stevenson, Morag, Easson, Richard, Goodwin, Adèle, McLean, Lorraine, McIntosh, Gillian, Goodwin, Glenn, Walker, Paul, Westwood, Julia, Marrs, Fiona, Thomson, Phillip, Cowley, Arthur, Christopoulos, Roger G, Pertwee, Ruth A, Ross   +16 more
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CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a

Molecular Pharmacology, 2007
The CB1 cannabinoid receptor is a G-protein coupled receptor that has important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection. We report the discovery of two structurally related CB1 cannabinoid receptor interacting proteins (CRIP1a and CRIP1b) that bind to the distal C-terminal tail of CB1.
Jason L, Niehaus, Yunguang, Liu, Kathleen T, Wallis, Michaela, Egertová, Sheela G, Bhartur, Somnath, Mukhopadhyay, Shanping, Shi, Hengjun, He, Dana E, Selley, Allyn C, Howlett, Maurice R, Elphick, Deborah L, Lewis   +11 more
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Modulation of cannabinoid receptor signaling by endocannabinoids

2022
AbstractEndocannabinoids (eCBs) are endogenous lipid molecules that activate the cannabinoid receptor 1 (CB1), a G protein coupled receptor (GPCR) that signals primarily through the Gi/o family of G proteins to regulate neurotransmitter release. Consequently, CB1 is an important therapeutic target for several neurological disorders.
Kaavya Krishna Kumar, Michael J. Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S. Powers, Lipin Ji, Spyros P. Nikas, Maria Gerasi, Kiran Vemuri, Ron O. Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian Kobilka   +14 more
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Modulation of transmitter release via presynaptic cannabinoid receptors

Trends in Pharmacological Sciences, 2001
Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In this article, the effects of modulation of transmitter release by cannabinoids in both the CNS and the PNS of various species, including humans, will be discussed ...
E, Schlicker, M, Kathmann
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Modulation of Excitatory Synaptic Transmission During Cannabinoid Receptor Activation

Cellular and Molecular Neurobiology, 2021
The present research has reported that cannabinoid receptor 1 (CB1) agonist, delta-(9)-tetrahydrocannabinol (THC) modulates synaptogenesis during overexcitation. Microtubule and synaptic distribution, poly(ADP)-ribose (PAR) accumulation were estimated during overexcitation and in the presence of THC.
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