Results 171 to 180 of about 247,667 (242)

Endocannabinoid system modulation for visceral abdominal pain in inflammatory bowel disease and irritable bowel syndrome: A protocol for systematic review and meta-analysis. [PDF]

HRB Open Res
Lane RM, Egan LJ, McGuire BE, McKernan DP, O'Mahony SM, Finn DP.   +5 more
europepmc   +1 more source

Editorial: Neurobiological basis of substance use disorders: new findings and perspectives. [PDF]

Front Neurosci
Favoretto CA, Loss CM, Vozella V, Cruz FC.   +3 more
europepmc   +1 more source

Multiple Roles of Cannabinoids in the Olfactory System. [PDF]

Brain Sci
Heinbockel T, Brown EA.
europepmc   +1 more source

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Enantio-specific Allosteric Modulation of Cannabinoid 1 Receptor

ACS Chemical Neuroscience, 2017
The cannabinoid 1 receptor (CB1R) is one of the most widely expressed metabotropic G protein-coupled receptors in brain, and its participation in various (patho)physiological processes has made CB1R activation a viable therapeutic modality.
R. Laprairie, P. Kulkarni, J. Deschamps, M. Kelly, D. Janero, M. Cascio, Lesley A. Stevenson, R. Pertwee, T. Kenakin, E. Denovan‐Wright, G. Thakur   +10 more
semanticscholar   +3 more sources

Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor

Angewandte Chemie - International Edition, 2018
Timothy Clark, Noureldin Saleh, Christofer Tautermann   +2 more
exaly   +2 more sources

Selective cannabinoid receptor 2 modulators: a patent review 2009 – present

Expert Opinion on Therapeutic Patents, 2012
Doris Riether
exaly   +2 more sources

Allosteric Modulation of the Cannabinoid CB1 Receptor

Molecular Pharmacology, 2005
We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), Org 27759 (3-ethyl-5-fluoro-1H-indole-2-carboxylic acid [2-94-dimethylamino-phenyl)-ethyl]-amide), and Org 29647 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid (1-benzyl-pyrrolidin-3-yl)-amide, 2 ...
Martin R, Price, Gemma L, Baillie, Adèle, Thomas, Lesley A, Stevenson, Morag, Easson, Richard, Goodwin, Adèle, McLean, Lorraine, McIntosh, Gillian, Goodwin, Glenn, Walker, Paul, Westwood, Julia, Marrs, Fiona, Thomson, Phillip, Cowley, Arthur, Christopoulos, Roger G, Pertwee, Ruth A, Ross   +16 more
openaire   +2 more sources

Modulation of cannabinoid receptor signaling by endocannabinoids

2022
Abstract Endocannabinoids (eCBs) are endogenous lipid molecules that activate the cannabinoid receptor 1 (CB1), a G protein coupled receptor (GPCR) that signals primarily through the G i/o family of G proteins to regulate neurotransmitter release.
Kaavya Krishna Kumar, Michael J. Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S. Powers, Lipin Ji, Spyros P. Nikas, Maria Gerasi, Kiran Vemuri, Ron O. Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian Kobilka   +14 more
openaire   +1 more source