Results 1 to 10 of about 22,652 (233)
CB1 Cannabinoid Receptor Signaling and Biased Signaling [PDF]
Molecules, 2021 The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration.
Luciana M. Leo, Mary E. Abood
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Voltage dependence of the cannabinoid CB1 receptor
Frontiers in Pharmacology, 2022 Cannabinoids produce their characteristic effects mainly by binding to two types of G-protein coupled receptors (GPCRs), the CB1 and CB2 cannabinoid receptors.
Esty Goldberger +2 more
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The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. [PDF]
PLoS ONE, 2008 Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation.
Blerina Kola +11 more
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Internalization and Recycling of the CB1 Cannabinoid Receptor [PDF]
Journal of Neurochemistry, 1999 Abstract : Tolerance develops rapidly to cannabis, cannabinoids, and related drugs acting at the CB1 cannabinoid receptor. However, little is known about what happens to the receptor as tolerance is developing. In this study, we have found that CB1 receptors are rapidly internalized following agonist binding and receptor activation ...
K Mackie
exaly +3 more sources
AB-MDMSBA-Not a Synthetic Cannabinoid Receptor Agonist. [PDF]
Pharmacol Res PerspectThis study uses classical in vitro pharmacology approaches to establish that AB‐MDMSBA does not bind to or activate the cannabinoid CB1 receptor and therefore should not be classified as a synthetic cannabinoid receptor agonist. ABSTRACT Synthetic cannabinoids remain one of the most prominent classes of New Psychoactive Substances (NPS).
Patel M +4 more
europepmc +2 more sources
Crystal Structure of the Human Cannabinoid Receptor CB1 [PDF]
Cell, 2016 Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications and a long history of recreational use. CB1 is activated by endocannabinoids and is a promising therapeutic target for pain management, inflammation, obesity, and substance ...
Tian Hua, Kiran Vemuri, Mengchen Pu
exaly +3 more sources
Short-Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses. [PDF]
Vet OphthalmolABSTRACT Objective To assess the effect of orally administered cannabidiol (CBD) on TonoVet measured intraocular pressure (IOP) and Schirmer tear test I (STT) in horses. Animal Studied Horse. Procedure This was a masked, randomized, balanced cross‐over study of six healthy adult horses.
Diehl K, Sheridan C, Reed R.
europepmc +2 more sources
Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. [PDF]
PLoS ONE, 2007 Characterization of intrinsic and extrinsic factors regulating the self-renewal/division and differentiation of stem cells is crucial in determining embryonic stem (ES) cell fate.
Shuxian Jiang +8 more
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Canadian Journal of Pain, 2023 Background Preclinical and clinical evidence suggests that cannabis has potential analgesic properties. However, cannabinoid receptor expression and localization within spinal cord pain processing circuits remain to be characterized across sex and ...
Jessica Parnell +8 more
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Frontiers in Cellular Neuroscience, 2021 There is evidence of ghrelinergic-cannabinoidergic interactions in the central nervous system (CNS) that may impact on the plasticity of reward circuits. The aim of this article was to look for molecular and/or functional interactions between cannabinoid
Alejandro Lillo +12 more
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