Results 31 to 40 of about 22,652 (233)

New Perspectives in the Studies on Endocannabinoid and Cannabis: Cannabinoid Receptors and Schizophrenia

Journal of Pharmacological Sciences, 2004
Cannabis consumption may induce psychotic states in normal individuals, worsen psychotic symptoms of schizophrenic patients, and may facilitate precipitation of schizophrenia in vulnerable individuals.
Hiroshi Ujike, Yukitaka Morita
doaj   +1 more source

Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease

, 2014
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
Silvia Cianci, ROMANO, ADELE, Romano, A, M. r. Elphick, Gianluigi Vendemiale, Pace, Lorenzo, Elphick, Maurice R, Bedse, G, Angelo M. Lavecchia, Gaurav Bedse, GAETANI, SILVANA, VENDEMIALE, GIANLUIGI, LAVECCHIA, ANGELO MICHELE, @CORRESPONDING AUTHOR, Vendemiale, G, CIANCI, SILVIA, Pace Lorenzo, Lorenzo Federico Pace, Adele Romano, Gaetani, S, Tommaso Cassano, BEDSE, GAURAV, Lorenzo, P, Caterina Grillo, Cassano, T, Grillo, C, Laferla, Frank M, ALTIERI, Fabio, Elphick, MR, LaFerla, FM, Maurice R. Elphick, GRILLO, CATERINA, Silvana Gaetani, Frank M. LaFerla, F. m. Laferla, CASSANO, TOMMASO, Lavecchia, AM, Fabio Altieri, Altieri, F, Cianci, S   +39 more
core   +1 more source

Constitutive Endocytic Cycle of the CB1 Cannabinoid Receptor [PDF]

Journal of Biological Chemistry, 2004
The CB1 cannabinoid receptor (CB1R) displays a significant level of ligand-independent (i.e. constitutive) activity, either when heterologously expressed in nonneuronal cells or in neurons where CB1Rs are endogenous. The present study investigates the consequences of constitutive activity on the intracellular trafficking of CB1R.
Christophe, Leterrier, Damien, Bonnard, Damien, Carrel, Jean, Rossier, Zsolt, Lenkei   +4 more
openaire   +2 more sources

Differential expression of brain cannabinoid receptors between repeatedly stressed males and females may play a role in age and gender-related difference in traumatic brain injury: Implications from animal studies

Frontiers in Neurology, 2014
Inconsistent gender differences in the outcome of TBI have been reported. The mechanism is unknown. In a recent male animal study, repeated stress followed by TBI had synergistic effects on brain gene expression and caused greater behavioral deficits ...
Guoqiang eXing, Guoqiang eXing, Janis eCarlton, Xiaolong eJiang, Jillian eWen, Jillian eWen, Min eJia, He eLi   +7 more
doaj   +1 more source

Novel Adamantyl Cannabinoids as CB1 Receptor Probes [PDF]

Journal of Medicinal Chemistry, 2013
In previous studies, compound 1 (AM411), a 3-(1-adamantyl) analogue of the phytocannabinoid (-)-Δ(8)-tetrahydrocannabinol (Δ(8)-THC), was shown to have improved affinity and selectivity for the CB1 receptor. In this work, we further explored the role of the 1-adamantyl group at the C-3 position in a series of tricyclic cannabinoid analogues modified at
Ganesh A, Thakur, Shama, Bajaj, Carol, Paronis, Yan, Peng, Anna L, Bowman, Lawrence S, Barak, Marc G, Caron, Demon, Parrish, Jeffrey R, Deschamps, Alexandros, Makriyannis   +9 more
openaire   +2 more sources

Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors-dependent manner

Journal of Pharmacological Sciences, 2019
Neuropathic pain sometimes occurs during chemotherapy with paclitaxel or HIV/AIDS antiretroviral therapy with nucleoside reverse transcriptase inhibitors (NRTIs).
Willias Masocha, Amal Thomas
doaj   +1 more source

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.

, 2008
OBJECTIVE Blockade of the CB1 receptor is one of the promising strategies for the treatment of obesity. Although antagonists suppress food intake and reduce body weight, the role of central versus peripheral CB1 activation on weight loss and related ...
Nogueiras, Ruben, Klein, Marcella, Liposits, Zsolt, Tschöp, Matthias H., Watanabe, Masahiko, Rohner-Jeanrenaud, Francoise, Wittmann, Gábor, Veyrat-Durebex, Christelle, Tschöp, Johannes, Fekete, Csaba, Reizes, Ofer, Woods, Stephen C., Suchanek, Paula M., Caldwell, Charles   +13 more
core   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells [PDF]

PeerJ, 2019
Background Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have been sporadic reports of co-consumption of illicit drugs with rodenticides such as warfarin and brodifacoum (BFC) over
Shivani Sachdev, Rochelle Boyd, Natasha L. Grimsey, Marina Santiago, Mark Connor   +4 more
doaj   +2 more sources

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source