Results 31 to 40 of about 43,721 (231)

High-resolution crystal structure of the human CB1 cannabinoid receptor

Nature, 2016
The human cannabinoid G-protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2-AG) and to the widely consumed plant phytocannabinoid Δ9-tetrahydrocannabinol (THC ...
Zhenhua Shao, Jie Yin, Karen M. Chapman, Magdalena G Grzemska, Lindsay D. Clark, Junmei Wang, D. Rosenbaum   +6 more
semanticscholar   +1 more source

Mechanism of the Interaction of Cannabinoid System in Central Amygdale with Opioid System [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008
Background and objectives Cannabinoids which are active compounds of marijuana show some pharmacological effects similar to the opioids. There are also functional interactions between both cannabinoid and opioid systems. In this study we investigated the
SH Sarahroodi, A Arzi, MR Zarrindast, MJ Khodayar   +3 more
doaj   +1 more source

Novel putative ligands of cannabinoid receptors: synthesis and effects on cell signaling and neuronal functions [PDF]

The Ukrainian Biochemical Journal, 2023
Cannabinoid ligands are known to possess neuroprotective actions and may have utility in the treatment of neurodegeneration. The major targets for cannabinoids include the classical CB1 cannabinoid receptor, as well as the novel cannabinoid receptor ...
J. Senkiv, A. Kryshchyshyn-Dylevych, D. Khylyuk, M. Wujec, R. Stoika, A. J. Irving, R. Lesyk   +6 more
doaj   +1 more source

Cannabinoid Receptor Activation Disrupts the Internal Structure of Hippocampal Sharp Wave–Ripple Complexes

Journal of Pharmacological Sciences, 2012
Cannabinoid agonists impair hippocampus-dependent learning and memory. Using mouse hippocampal slice preparations, we examined the effect of anandamide, an endogenous cannabinoid, on sharp wave–ripple (SW-R) complexes, which are believed to mediate ...
Yi Sun, Hiroaki Norimoto, Xiao-Ping Pu, Norio Matsuki, Yuji Ikegaya   +4 more
doaj   +1 more source

Cannabinoid CB1 Receptor Calibrates Excitatory Synaptic Balance in the Mouse Hippocampus

Journal of Neuroscience, 2015
The endocannabinoid system negatively regulates the release of various neurotransmitters in an activity-dependent manner, thereby influencing the excitability of neuronal circuits.
K. Monory, M. Polack, Anita Remus, B. Lutz, M. Korte   +4 more
semanticscholar   +1 more source

New Perspectives in the Studies on Endocannabinoid and Cannabis: Cannabinoid Receptors and Schizophrenia

Journal of Pharmacological Sciences, 2004
Cannabis consumption may induce psychotic states in normal individuals, worsen psychotic symptoms of schizophrenic patients, and may facilitate precipitation of schizophrenia in vulnerable individuals.
Hiroshi Ujike, Yukitaka Morita
doaj   +1 more source

Differential expression of brain cannabinoid receptors between repeatedly stressed males and females may play a role in age and gender-related difference in traumatic brain injury: Implications from animal studies

Frontiers in Neurology, 2014
Inconsistent gender differences in the outcome of TBI have been reported. The mechanism is unknown. In a recent male animal study, repeated stress followed by TBI had synergistic effects on brain gene expression and caused greater behavioral deficits ...
Guoqiang eXing, Guoqiang eXing, Janis eCarlton, Xiaolong eJiang, Jillian eWen, Jillian eWen, Min eJia, He eLi   +7 more
doaj   +1 more source

Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes

Frontiers in Pharmacology, 2018
Cannabigerol (CBG) is one of the major phytocannabinoids present in Cannabis sativa L. that is attracting pharmacological interest because it is non-psychotropic and is abundant in some industrial hemp varieties.
Gemma Navarro, K. Varani, Irene Reyes-Resina, Verónica Sánchez de Medina, Rafael Rivas-Santisteban, C. Sánchez-Carnerero Callado, F. Vincenzi, S. Casano, C. Ferreiro-Vera, E. Canela, P. Borea, X. Nadal, R. Franco   +12 more
semanticscholar   +1 more source

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

Cell, 2020
SUMMARY Human endocannabinoid systems modulate multiple physiological processes mainly through the activation of cannabinoid receptors CB1 and CB2. Their high sequence similarity, low agonist selectivity, and lack of activation and G protein-coupling ...
T. Hua, Xiaoting Li, Lijie Wu, Christos Iliopoulos-Tsoutsouvas, Yuxia Wang, Meng Wu, Ling Shen, Christina A. Brust, S. Nikas, Feng Song, Xiyong Song, Shuguang Yuan, Qianqian Sun, Yiran Wu, Shan Jiang, Travis W. Grim, Othman Benchama, Edward L. Stahl, N. Zvonok, Suwen Zhao, L. Bohn, A. Makriyannis, Zhi-jie Liu   +22 more
semanticscholar   +1 more source

Constitutive Endocytic Cycle of the CB1 Cannabinoid Receptor [PDF]

Journal of Biological Chemistry, 2004
The CB1 cannabinoid receptor (CB1R) displays a significant level of ligand-independent (i.e. constitutive) activity, either when heterologously expressed in nonneuronal cells or in neurons where CB1Rs are endogenous. The present study investigates the consequences of constitutive activity on the intracellular trafficking of CB1R.
Christophe, Leterrier, Damien, Bonnard, Damien, Carrel, Jean, Rossier, Zsolt, Lenkei   +4 more
openaire   +2 more sources