Results 1 to 10 of about 36,753 (242)

Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation [PDF]

Frontiers in Molecular Neuroscience
CB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at their terminals and their impact on motor behavior remain unknown. In this study, we investigate the presence of CB1-GPR55 heteromers
José Arturo Avalos-Fuentes, Rodolfo Sánchez-Zavaleta, Ihosvany Rodríguez Pérez, Rafael Jijón-Lorenzo, Refugio Cruz-Trujillo, María Fernanda González de la Torre, Martha Abigail Villareal Zuñiga, Benjamín Florán   +7 more
doaj   +2 more sources

Neuroglial CB1 receptors modulate hippocampal processes in a sex-dependent manner [PDF]

Biology of Sex Differences
Background Navigation and memory are hippocampal functions that are essential for survival. One of the key modulators of hippocampal activity is the endocannabinoid system through the cannabinoid receptor type 1 (CB1).
Jon Egaña-Huguet, Lucía Sangroniz-Beltrán, Andrés M. Baraibar, Pablo Reyes-Velásquez, Nicolas F. Landgraf, Paula Torres-Maldonado, Cathaysa Rodríguez-Cedrés, Francisca Julio-Kalajzic, Joaquín Piriz, Almudena Ramos, Pedro Grandes, Giovanni Marsicano, Susana Mato, María Ceprián, Edgar Soria-Gómez   +14 more
doaj   +2 more sources

Internalization and Recycling of the CB1 Cannabinoid Receptor [PDF]

Journal of Neurochemistry, 1999
Abstract : Tolerance develops rapidly to cannabis, cannabinoids, and related drugs acting at the CB1 cannabinoid receptor. However, little is known about what happens to the receptor as tolerance is developing. In this study, we have found that CB1 receptors are rapidly internalized following agonist binding and receptor activation ...
K Mackie
exaly   +3 more sources

AB-MDMSBA-Not a Synthetic Cannabinoid Receptor Agonist. [PDF]

Pharmacol Res Perspect
This study uses classical in vitro pharmacology approaches to establish that AB‐MDMSBA does not bind to or activate the cannabinoid CB1 receptor and therefore should not be classified as a synthetic cannabinoid receptor agonist. ABSTRACT Synthetic cannabinoids remain one of the most prominent classes of New Psychoactive Substances (NPS).
Patel M, Ganeshan D, Horgan I, Partington H, Glass M.   +4 more
europepmc   +2 more sources

CB1 Cannabinoid Receptor Expression in the Striatum: Association with Corticostriatal Circuits and Developmental Regulation

Frontiers in Pharmacology, 2012
Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid ...
Vincent Van Waes, Joel A Beverley, Heinz Steiner   +2 more
exaly   +3 more sources

Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction [PDF]

Journal of Biomedical Science
Background Despite therapeutic advances, atherosclerosis remains a major global health challenge. Most current treatments target systemic risk factors rather than the diseased vascular wall.
Dai-Jung Chung, Shao-Peng Chen, Wei-Hsuan Liu, Chia-Yu Liu, Nan-Wei Su, Chen Hsu, Hsin-Ya Tsai, Kai-Chien Yang, Cho-Kai Wu, Sheng-Wei Lin, Jiun‑Jie Shie, Ming-Tao Zhao, Tzu-Tang Wei   +12 more
doaj   +2 more sources

Short-Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses. [PDF]

Vet Ophthalmol
ABSTRACT Objective To assess the effect of orally administered cannabidiol (CBD) on TonoVet measured intraocular pressure (IOP) and Schirmer tear test I (STT) in horses. Animal Studied Horse. Procedure This was a masked, randomized, balanced cross‐over study of six healthy adult horses.
Diehl K, Sheridan C, Reed R.
europepmc   +2 more sources

Novel putative ligands of cannabinoid receptors: synthesis and effects on cell signaling and neuronal functions [PDF]

The Ukrainian Biochemical Journal, 2023
Cannabinoid ligands are known to possess neuroprotective actions and may have utility in the treatment of neurodegeneration. The major targets for cannabinoids include the classical CB1 cannabinoid receptor, as well as the novel cannabinoid receptor ...
J. Senkiv, A. Kryshchyshyn-Dylevych, D. Khylyuk, M. Wujec, R. Stoika, A. J. Irving, R. Lesyk   +6 more
doaj   +1 more source

Developmental and visual input-dependent regulation of the CB1 cannabinoid receptor in the mouse visual cortex. [PDF]

PLoS ONE, 2013
The mammalian visual system exhibits significant experience-induced plasticity in the early postnatal period. While physiological studies have revealed the contribution of the CB1 cannabinoid receptor (CB1) to developmental plasticity in the primary ...
Taisuke Yoneda, Katsuro Kameyama, Kazusa Esumi, Yohei Daimyo, Masahiko Watanabe, Yoshio Hata   +5 more
doaj   +1 more source

Yin and yang of cannabinoid CB1 receptor: CB1 deletion in immune cells causes exacerbation while deletion in non-immune cells attenuates obesity

iScience, 2022
Summary: While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested.
Kathryn Miranda, William Becker, Philip B. Busbee, Nicholas Dopkins, Osama A. Abdulla, Yin Zhong, Jiajia Zhang, Mitzi Nagarkatti, Prakash S. Nagarkatti   +8 more
doaj   +1 more source