Internalization and Recycling of the CB1 Cannabinoid Receptor [PDF]
Journal of Neurochemistry, 1999 Abstract : Tolerance develops rapidly to cannabis, cannabinoids, and related drugs acting at the CB1 cannabinoid receptor. However, little is known about what happens to the receptor as tolerance is developing. In this study, we have found that CB1 receptors are rapidly internalized following agonist binding and receptor activation ...
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CB1 Cannabinoid Receptor Signaling and Biased Signaling
Molecules, 2021 The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration.
Mary Abood, Leo Lm
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Neuroglial CB1 receptors modulate hippocampal processes in a sex-dependent manner [PDF]
Biology of Sex DifferencesBackground Navigation and memory are hippocampal functions that are essential for survival. One of the key modulators of hippocampal activity is the endocannabinoid system through the cannabinoid receptor type 1 (CB1).
Jon Egaña-Huguet +14 more
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Novel putative ligands of cannabinoid receptors: synthesis and effects on cell signaling and neuronal functions [PDF]
The Ukrainian Biochemical Journal, 2023 Cannabinoid ligands are known to possess neuroprotective actions and may have utility in the treatment of neurodegeneration. The major targets for cannabinoids include the classical CB1 cannabinoid receptor, as well as the novel cannabinoid receptor ...
J. Senkiv +6 more
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Developmental and visual input-dependent regulation of the CB1 cannabinoid receptor in the mouse visual cortex. [PDF]
PLoS ONE, 2013 The mammalian visual system exhibits significant experience-induced plasticity in the early postnatal period. While physiological studies have revealed the contribution of the CB1 cannabinoid receptor (CB1) to developmental plasticity in the primary ...
Taisuke Yoneda +5 more
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iScience, 2022 Summary: While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested.
Kathryn Miranda +8 more
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Cell Death Discovery, 2022 Cannabinoid receptors, CB1 and CB2, have been implicated as emerging targets for cancer therapy. Herein, we investigated the potential regulation mechanism of CB1 and its implications in colorectal cancer.
You-Ming Deng +4 more
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Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]
PLoS ONE, 2014 Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow +5 more
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High spatio-temporal resolution pollutant measurements of on-board vehicle emissions using ultra-fast response gas analyzers [PDF]
Atmospheric Measurement Techniques, 2018 Existing ultra-fast response engine exhaust emissions analyzers have been adapted for on-board vehicle use combined with GPS data. We present, for the first time, how high spatio-temporal resolution data products allow transient features associated ...
M. Irwin +5 more
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The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra. [PDF]
PLoS ONE, 2018 Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum and substantia nigra, where they play a role in learning ...
Margaret I Davis +7 more
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