Results 41 to 50 of about 71,388 (222)
Phytocannabinoids as novel therapeutic agents in CNS disorders [PDF]
, 2012 The Cannabis sativa herb contains over 100 phytocannabinoid (pCB) compounds and has been used for thousands of years for both recreational and medicinal purposes.
Hill, Andrew J. +3 more
core +1 more source
CB1 Cannabinoid Receptor Signaling and Biased Signaling
Molecules, 2021 The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration.
Luciana M. Leo, Mary E. Abood
doaj +1 more source
Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]
, 2019 CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P. +7 more
core +2 more sources
, 2012 Only a severely restricted class of tensor fields can provide classical spacetime geometries, namely those that can carry matter field equations that are predictive, interpretable and quantizable.
B. Hassett +8 more
core +1 more source
AGING MEDICINE, EarlyView.Foreign language learning in older adults reorganizes thalamic and caudate connectivity, in a process topographically overlapping with the expression of receptors and genes related to neuroplasticity. ABSTRACT Objectives Neuroimaging studies suggest that Foreign Language Learning (FLL) influences resting‐state functional connectivity (rs‐FC) within the
Giovanna Bubbico +8 more
wiley +1 more source
International Journal of Infectious Diseases, 2017 Background: The endocannabinoid system is involved in the pathogenesis of liver fibrosis. However, most of the findings in this area have come from experimental studies in animal models or clinical trials on chronic hepatitis C.
Erhei Dai +7 more
doaj +1 more source
PLoS ONE, 2020 BackgroundThere is a correlation between the endocannabinoid system and hepatic fibrosis based on the activation of CB1 and CB2 receptors; where CB1 has profibrogenic effects. Gene therapy with a plasmid carrying a shRNA for CB1 delivered by hydrodynamic
Adriana Díaz-Rivera +9 more
doaj +1 more source
Reversible disruption of pre-pulse inhibition in hypomorphic-inducible and reversible CB1-/- mice. [PDF]
PLoS ONE, 2012 Although several genes are implicated in the pathogenesis of schizophrenia, in animal models for such a severe mental illness only some aspects of the pathology can be represented (endophenotypes).
Maria Franca Marongiu +10 more
doaj +1 more source
Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models
AGING MEDICINE, EarlyView.CB1 receptor (CB1R) expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of Alzheimer's patients. CB1R levels negatively correlated with amyloid‐β and tau pathology. In addition, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4‐42 mice.
Nike von Borcke +4 more
wiley +1 more source
Unawareness, Beliefs and Games [PDF]
, 2007 We define a generalized state-space model with interactive unawareness and probabilistic beliefs. Such models are desirable for many potential applications of asymmetric unawareness.
Heifetz, Aviad +2 more
core +4 more sources