Results 41 to 50 of about 36,753 (242)

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system

, 2008
INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White, Francesca Lolli, Farkas, I., Amin, F., Mirjam Christ-Crain, Kola, Blerina, Fekete, Csaba, George Kunos, Kola, B., Faisal Amin, A. B. Grossman, M. Korbonits, Blerina Kola, Liposits, Zsolt, G. Kunos, Ashley B Grossman, B. Kola, Amin, F, Gábor Wittmann, Kunos, George, Christ-Crain, M, Farkas, Imre, Lolli, F, Zsolt Liposits, Lolli, F., F. Amin, Farkas, I, Christ-Crain, M., Korbonits, M., I. Farkas, Grossman, AB, C. Fekete, Kola, B, Harvey-White, J., Wittmann, Gábor, Korbonits, Márta, G. Wittmann, Harvey-White, J, Fekete, C, Harvey-White, Judith, Márta Korbonits, Imre Farkas, Liposits, Z, Z. Liposits, Grossman, Ashley B., Ashley B. Grossman, Wittmann, G., Christ-Crain, Mirjam, Amin, Faisal, Lolli, Francesca, Liposits, Z., M. Christ Crain, J. Harvey White, Fekete, C., Korbonits, M, Kunos, G., Csaba Fekete, Grossman, A. B., Kunos, G, Wittmann, G   +59 more
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GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Reversible disruption of pre-pulse inhibition in hypomorphic-inducible and reversible CB1-/- mice. [PDF]

PLoS ONE, 2012
Although several genes are implicated in the pathogenesis of schizophrenia, in animal models for such a severe mental illness only some aspects of the pathology can be represented (endophenotypes).
Maria Franca Marongiu, Daniela Poddie, Susanna Porcu, Maria Francesca Manchinu, Maria Paola Castelli, Valeria Sogos, Valentina Bini, Roberto Frau, Elisabetta Caredda, Maria Collu, Maria Serafina Ristaldi   +10 more
doaj   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Hepatic expression of cannabinoid receptors CB1 and CB2 correlate with fibrogenesis in patients with chronic hepatitis B

International Journal of Infectious Diseases, 2017
Background: The endocannabinoid system is involved in the pathogenesis of liver fibrosis. However, most of the findings in this area have come from experimental studies in animal models or clinical trials on chronic hepatitis C.
Erhei Dai, Lianshan Zhang, Lihong Ye, Shiqing Wan, Lulu Feng, Qi Qi, Fang Yao, Zhen Li   +7 more
doaj   +1 more source

Hydrodynamics-based liver transfection achieves gene silencing of CB1 using short hairpin RNA plasmid in cirrhotic rats.

PLoS ONE, 2020
BackgroundThere is a correlation between the endocannabinoid system and hepatic fibrosis based on the activation of CB1 and CB2 receptors; where CB1 has profibrogenic effects. Gene therapy with a plasmid carrying a shRNA for CB1 delivered by hydrodynamic
Adriana Díaz-Rivera, Alejandra Meza-Ríos, Victoria Chagoya de Sánchez, Gabriela Velasco-Loyden, Leonel García-Benavides, Luis F Jave-Suarez, Hugo Christian Monroy-Ramirez, Arturo Santos-García, Juan Armendáriz-Borunda, Ana Sandoval-Rodríguez   +9 more
doaj   +1 more source

Colossal Photovoltaic Current in Ferroelectric Oxide by Constructing Defect Band

Advanced Science, EarlyView.
Colossal photovoltaic current density of 34.36 mA/cm2 under 375 nm illumination has been achieved in the Pb‐deficient PbTiO3 film. The ultraviolet photoresponsivity surpasses that of all reported ferroelectric materials. This enhancement is attributed to the junction effect between the Pb‐deficient and non‐defective layers.
Yiran Sun, Zhenbang Dai, Xingzhong Cao, Peng Zhang, Chen Lin, Zihang Huang, Ruian Zhang, Yi Fu, Xuanyu Jiang, He Tian, Jingjing Xue, Kaifeng Wu, Junhui Wang, Tianqi Deng, Andrew M. Rappe, Gaorong Han, Zhaohui Ren   +16 more
wiley   +1 more source

Interação entre os sistemas adenosinérgico e endocanabinóide, através dos receptores A1 e CB1, no controle da memória espacial [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaOs sistemas endocanabinóide e adenosinérgico, através dos receptores A1 e CB1, compartilham uma série de características ...
Assini, Fabrício Luiz
core  

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales. [PDF]

, 2007
[spa] La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden
Carriba Domínguez, Paulina
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