Results 21 to 30 of about 36,753 (242)
Molecules, 2021 Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational principles of plasma ...
Miquel Saumell-Esnaola +6 more
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Frontiers in Behavioral Neuroscience, 2021 Cannabinoid receptors 1 and 2 (CB1 and CB2, respectively) play an important role in maintaining the integrity of the blood–brain barrier (BBB). On the other hand, BBB dysfunction is a common feature in drug-resistant epilepsy.
María de los Ángeles Nuñez-Lumbreras +12 more
doaj +1 more source
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. [PDF]
PLoS ONE, 2013 Cannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date.We examined the distribution of CB1 protein in ...
Alexander H Benz +10 more
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Cannabinoid CB1 receptors regulate salivation
Scientific Reports, 2022 AbstractSaliva serves multiple important functions within the body that we typically take for granted, such as helping prepare food for swallowing and defense against oral pathogens. Dry mouth is a primary symptom of Sjӧgren’s syndrome and is a side effect of many drug treatments.
Kelsey Andreis +6 more
openaire +3 more sources
Loss of cannabinoid receptor CB1 induces preterm birth. [PDF]
PLoS ONE, 2008 Preterm birth accounting approximate 10% of pregnancies in women is a tremendous social, clinical and economic burden. However, its underlying causes remain largely unknown.
Haibin Wang, Huirong Xie, Sudhansu K Dey
doaj +1 more source
Partial cloning of CB1 cDNA and CB1 mRNA changes in stress responses in the Solea solea [PDF]
Molecular and Cellular Endocrinology, 2008 Endogenous cannabinoids, through the CB1 receptor, are involved in the control of several functions including stress responses. The aim of this study was to investigate the presence of cannabinoid receptor CB1 in the sole ovary by partial cloning of brain CB1 cDNA; in a stress paradigm of disturbance by handling, which consisted in catching, netting ...
F A, Palermo +4 more
openaire +2 more sources
Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]
, 2013 CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter +7 more
core +1 more source
Voltage dependence of the cannabinoid CB1 receptor
Frontiers in Pharmacology, 2022 Cannabinoids produce their characteristic effects mainly by binding to two types of G-protein coupled receptors (GPCRs), the CB1 and CB2 cannabinoid receptors. The CB1 receptor is the main cannabinoid receptor in the central nervous system, and it participates in many brain functions.
Esty Goldberger +2 more
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Canadian Journal of Pain, 2023 Background Preclinical and clinical evidence suggests that cannabis has potential analgesic properties. However, cannabinoid receptor expression and localization within spinal cord pain processing circuits remain to be characterized across sex and ...
Jessica Parnell +8 more
doaj +1 more source
Probing the Interaction of SR141716A with the CB1 Receptor [PDF]
Journal of Biological Chemistry, 2012 SR141716A binds selectively to the brain cannabinoid (CB1) receptor and exhibits a potent inverse agonist/antagonist activity. Although SR141716A, also known as rimonabant, has been withdrawn from the market due to severe side effects, there remains interest in some of its many potential medical applications.
Joong-Youn, Shim +2 more
openaire +2 more sources