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Interfering with reconsolidation by rimonabant results in blockade of heroin-associated memory [PDF]
Frontiers in PharmacologyDrug-associated pathological memory remains a critical factor contributing to the persistence of substance use disorder. Pharmacological amnestic manipulation to interfere with drug memory reconsolidation has shown promise for the prevention of relapse ...
Jiang Lin +11 more
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Rimonabant: From RIO to Ban [PDF]
Journal of Obesity, 2011 Endocannabinoid antagonism as a treatment for obesity and the metabolic syndrome became a hugely anticipated area of pharmacology at the start of the century. The CB1 receptor antagonist Rimonabant entered the European mass market on the back of several
Amir H. Sam +2 more
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Influence of rimonabant treatment on peripheral blood mononuclear cells; flow cytometry analysis and gene expression profiling [PDF]
PeerJ, 2015 The cannabinoid receptor type 1 (CB1) antagonist rimonabant has been used as treatment for obesity. In addition, anti-proliferative effects on mitogen-activated leukocytes have been demonstrated in vitro.
Stefan Almestrand +7 more
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CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes. [PDF]
PLoS ONE, 2018 Previous studies have shown that the CB1 receptor antagonist reverses steatohepatitis and its related features of metabolic syndrome, such as obesity and type 2 diabetes.
Eugene Chang +5 more
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Potential Implications of Rimonabant on Age-Related Oxidative Stress and Inflammation
Antioxidants, 2022 Over the last decades, growing interest has turned to preventive and therapeutic approaches for achieving successful aging. Oxidative stress and inflammation are fundamental features of cardiovascular diseases; therefore, potential targets of them can ...
Renáta Szabó +14 more
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Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice. [PDF]
PLoS ONE, 2011 Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes.
Chunxiu Hu +13 more
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Molecules, 2020 (1) Background: Acute administration of the cannabinoid receptor 1 (CB1R) inverse agonist Rimonabant (SR141716A) to fed Wistar rats was shown to elicit a rapid and short-lasting elevation of serum free fatty acids.
Günter A. Müller +3 more
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Rimonabant for treating tobacco dependence
Vascular Health and Risk Management, 2007 Michael B Steinberg1,2, Jonathan Foulds11University of Medicine and Dentistry of New Jersey–School of Public Health, Tobacco Dependence Program, New Brunswick, NJ, USA; 2University of Medicine and Dentistry of New Jersey–Robert Wood Johnson ...
Michael B Steinberg, Jonathan Foulds
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The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
Pathophysiology, 2021 Cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two G-protein-coupled cannabinoid receptors, CB1 and CB2.
Mansour Haddad
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Neurobiology of Disease, 2007 Preclinical and clinical research shows that the cannabinoid brain receptor type 1 (CB1) modulates alcohol- and nicotine-related behaviors. Throughout the nicotine-induced relapse to alcohol, the rats were pre-treated for 10 days with the CB1 cannabinoid
José Antonio López-Moreno +2 more
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