Melancholic features related to rimonabant [PDF]
General Hospital Psychiatry, 2009 Obesity is currently considered a global epidemic and its prevention and treatment is a major public health concern, demanding treatment which may combine a sociocultural approach, lifestyle modification, nutritional, pharmacological or surgical strategies.
Bernardo, de Mattos Viana +2 more
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Rimonabant: From RIO to Ban [PDF]
Journal of Obesity, 2011 Endocannabinoid antagonism as a treatment for obesity and the metabolic syndrome became a hugely anticipated area of pharmacology at the start of the century. The CB1 receptor antagonist Rimonabant entered the European mass market on the back of several
Amir H. Sam +2 more
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Influence of rimonabant treatment on peripheral blood mononuclear cells; flow cytometry analysis and gene expression profiling [PDF]
PeerJ, 2015 The cannabinoid receptor type 1 (CB1) antagonist rimonabant has been used as treatment for obesity. In addition, anti-proliferative effects on mitogen-activated leukocytes have been demonstrated in vitro.
Stefan Almestrand +7 more
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Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome [PDF]
Molecular AutismBackground Defective mitochondria and aberrant brain mitochondrial bioenergetics are consistent features in syndromic intellectual disability disorders, such as Rett syndrome (RTT), a rare neurologic disorder that severely affects mainly females carrying
Livia Cosentino +14 more
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CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes. [PDF]
PLoS ONE, 2018 Previous studies have shown that the CB1 receptor antagonist reverses steatohepatitis and its related features of metabolic syndrome, such as obesity and type 2 diabetes.
Eugene Chang +5 more
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Potential Implications of Rimonabant on Age-Related Oxidative Stress and Inflammation
Antioxidants, 2022 Over the last decades, growing interest has turned to preventive and therapeutic approaches for achieving successful aging. Oxidative stress and inflammation are fundamental features of cardiovascular diseases; therefore, potential targets of them can ...
Renáta Szabó +14 more
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Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice. [PDF]
PLoS ONE, 2011 Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes.
Chunxiu Hu +13 more
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Molecules, 2020 (1) Background: Acute administration of the cannabinoid receptor 1 (CB1R) inverse agonist Rimonabant (SR141716A) to fed Wistar rats was shown to elicit a rapid and short-lasting elevation of serum free fatty acids.
Günter A. Müller +3 more
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The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
Pathophysiology, 2021 Cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two G-protein-coupled cannabinoid receptors, CB1 and CB2.
Mansour Haddad
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Neurobiology of Disease, 2007 Preclinical and clinical research shows that the cannabinoid brain receptor type 1 (CB1) modulates alcohol- and nicotine-related behaviors. Throughout the nicotine-induced relapse to alcohol, the rats were pre-treated for 10 days with the CB1 cannabinoid
José Antonio López-Moreno +2 more
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