Results 41 to 50 of about 4,732 (172)
Melancholic features related to rimonabant [PDF]
General Hospital Psychiatry, 2009 Obesity is currently considered a global epidemic and its prevention and treatment is a major public health concern, demanding treatment which may combine a sociocultural approach, lifestyle modification, nutritional, pharmacological or surgical strategies.
Bernardo, de Mattos Viana +2 more
openaire +2 more sources
Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.The monocyclic sesquiterpene α‐humulene elicited a significant anxiolytic‐like behavior in adult zebrafish and no observable acute toxicity. Pharmacological dissection suggested that this effect is independent of the benzodiazepine (BZD) binding site on the gamma‐aminobutyric acid (GABA) type A receptor (GABAAR), but it depends on the serotonin type 3 ...
Alex de Souza Borges +9 more
wiley +1 more source
Biomolecules, 2019 The endocannabinoid system represents an integrated neuronal network involved in the control of several organisms’ functions, such as feeding behavior. A series of hybrids of 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-
Marilisa P. Dimmito +7 more
doaj +1 more source
Epilepsia, Volume 67, Issue 7, Page 3281-3299, July 2026.Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier +82 more
wiley +1 more source
Blood Pressure-Lowering Aspects of Lipid-Lowering and Anti-Diabetic Drugs
Pharmaceuticals, 2010 Several studies have shown that blood pressure can be lowered by the use of drugs that are not traditional antihypertensive drugs. This might be of clinical importance when many risk patients are treated by combination drug therapy in order to prevent ...
Peter M. Nilsson, Renata Cifkova
doaj +1 more source
Rimonabant, Gastrointestinal Motility and Obesity [PDF]
Current Neuropharmacology, 2012 Obesity and overweight affect more than half of the US population and are associated with a number of diseases. Rimonabant, a cannabinoid receptor 1 blocker in the endocannabinoid (EC) system, was indicated in Europe for the treatment of obesity and overweight patients with associated risk factors but withdrawn on Jan, 2009 because of side effects ...
Sun, Yan, Chen, Jiande
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Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Biomolecules, 2020 Obesity rates are increasing worldwide and there is a need for novel therapeutic treatment options. The endocannabinoid system has been linked to homeostatic processes, including metabolism, food intake, and the regulation of body weight.
Thomas Murphy, Bernard Le Foll
doaj +1 more source
Effectiveness of Alcohol Use Disorder Pharmacotherapies by Sex: Systematic Review and Meta‐Analysis
Drug and Alcohol Review, Volume 45, Issue 5, July 2026.ABSTRACT Issues Alcohol use disorder (AUD) shows sex‐related differences in prevalence, harm and treatment response. Despite growing interest in sex differences, evidence synthesis evaluating pharmacotherapy effectiveness by sex remains limited. Approach Web of Science, PubMed, Scopus, PsycINFO and Cochrane were searched twice.
Juliette Allen +11 more
wiley +1 more source
Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice. [PDF]
PLoS ONE, 2012 Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than ...
Heng Wei +15 more
doaj +1 more source