Results 61 to 70 of about 4,732 (172)

Gaining insights into MmpL3: combining structural and computational approaches to unlock transport and inhibitor‐binding mechanisms

Acta Crystallographica Section D, Volume 82, Issue 5, Page 550-570, May 2026.
This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami, Domenico Marson, Eiki Yamashita, Bruno Broshka, Ui Okada, Maho Aoki, Giannamaria Annunziato, Erik Laurini, Emanuele Carosati, Marco Pieroni   +9 more
wiley   +1 more source

Role of the endogenous cannabinoid system in nicotine addiction: novel insights

Frontiers in Psychiatry, 2015
Several lines of evidence have shown that the endogenous cannabinoids are implicated in several neuropsychiatric diseases. Notably, preclinical and human clinical studies have shown a pivotal role of the cannabinoid system in nicotine addiction.
Islam Hany Gamaleddin, Islam Hany Gamaleddin, Jose M. Trigo, Aliou eGueye, Alexander eZvonok, Alexandros eMakriyannis, Steven eGoldberg, Bernard eLe Foll, Bernard eLe Foll   +8 more
doaj   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Modern drugs for obesity and metabolic syndrome treatment (Review)

Сеченовский вестник, 2016
The article reviews modern anti-obesity drugs to identify new trends in effective and safe risk factors reduction (diabetes, cardiovascular and musculoskeletal diseases, cancer).
M. L. Maximov, O. V. Dralova, V. G. Kukes, V. N. Chubarev, V. V. Tarasov   +4 more
doaj  

Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss

BMC Endocrine Disorders, 2017
Background Evidence suggests that endocannabinoid system activation through the cannabinoid receptor 1 (CB1) is associated with enhanced liver injury, and CB1 antagonism may be beneficial.
Alison J. Dawson, Eric S. Kilpatrick, Anne-Marie Coady, Abeer M. M. Elshewehy, Youssra Dakroury, Lina Ahmed, Stephen L. Atkin, Thozhukat Sathyapalan   +7 more
doaj   +1 more source

Monlunabant in adults with obesity and metabolic syndrome: Open‐label extension of a phase 2a trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4366-4371, May 2026.
Filip K. Knop, George Kunos, Dror Dicker, Jean‐Sebastien Paquette, Louis Aronne, Oscar Birkhan, Ofir Frenkel, Thomas Holst‐Hansen, Karine Lalonde, Glenn Crater, for the trial investigators   +10 more
wiley   +1 more source

RP-HPLC Method Development and Its Validation for Quantitative Determination of Rimonabant in Human Plasma

Journal of Analytical Methods in Chemistry, 2012
A simple, accurate, and precise HPLC method was developed and validated for determination of rimonabant in human plasma. Following liquid-liquid extraction, chromatographic separation was accomplished using C18 column with mobile phase consisting of ...
Shravan Bankey, Ganesh Tapadiya, Jasvant Lamale, Deepti Jain, Shweta Saboo, S. S. Khadabadi   +5 more
doaj   +1 more source

Rehabilitating rimonabant [PDF]

Journal of Molecular Medicine, 2013
openaire   +2 more sources

The CB1 receptor agonist WIN 55,212-2 fails to evoke physical dependence in Swiss mice

Current Issues in Pharmacy and Medical Sciences
Potential ability of cannabinoids to produce dependence is still a controversial issue. In our study, in order to examine the cannabinoid physical dependence phenomenon we administered CB1 receptor agonist WIN55,212-2, afterwards, in order to ...
Barbara Budzyńska, Grażyna Biała
doaj