Results 71 to 80 of about 6,040 (212)
Health Technology Assessment, 2012 Background: Obesity [defined as a body mass index (BMI) ≥ 30 kg/m2] represents a considerable public health problem and is associated with a significant range of comorbidities and an increased mortality risk.
R Ara +14 more
doaj +1 more source
, 2012 Rimonabant (SR141716) and the structurally related AM251 are widely used in pharmacological experiments as selective cannabinoid receptor CB(1) antagonists / inverse agonists. Concentrations of 0.5-10 µM are usually applied in in vitro experiments.
Baur, R +5 more
core +1 more source
Effect of rimonabant on oesophageal motor function in man
, 2011 BACKGROUND: Cannabinoid type 1 (CB1) receptors are implicated in the control of transient lower oesophageal sphincter relaxations (TLESRs) in animals. In man, it is unclear whether CB1 receptors are involved in the control of oesophageal function.
A. Gasbarrini +19 more
core +1 more source
Role of the endogenous cannabinoid system in nicotine addiction: novel insights
Frontiers in Psychiatry, 2015 Several lines of evidence have shown that the endogenous cannabinoids are implicated in several neuropsychiatric diseases. Notably, preclinical and human clinical studies have shown a pivotal role of the cannabinoid system in nicotine addiction.
Islam Hany Gamaleddin +8 more
doaj +1 more source
Cannabinoid type I receptor antagonists (rimonabant) for smoking cessation [PDF]
, 2007 Rimonabant is a selective type 1 cannabinoid ( CB1) receptor antagonist. It may assist with smoking cessation by restoring the balance of the endocannabinoid system, which can be disrupted by prolonged use of nicotine.
Ussher, M +5 more
core +1 more source
Metalloids: Semi as Metals yet Full of Antimicrobial Potential
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm +2 more
wiley +1 more source
, 2011 Aim: To investigate whether rimonabant, a cannabinoid receptor antagonist , had inhibitory effects on inflammatory reactions in human umbilical vein endothelial cells (HUVEC).
黃南嵐;莊志明;林俊立;蔡佳醍;賴凌平 +1 more
core
, 2008 Rimonabant is an inverse agonist specific for cannabinoid receptors and selective for their cannabinoid-1 (CB1) subtype. Although CB1 receptors are more abundant in the central nervous system, rimonabant has many effects in the periphery, most of which ...
Hester van Diepen +5 more
core +1 more source
, 2020 International audienceSarcopenia is an age-related loss of muscle mass associated with changes in skeletal muscle protein homeostasis due to lipid accumulation and anabolic resistance; changes that are also commonly described in obesity.
Kristell Combe +9 more
core +1 more source
Antidepressant-like effects of Δ9-tetrahydrocannabinol and rimonabant in the olfactory bulbectomised rat model of depression [PDF]
, 2012 The endocannabinoid signalling system is widely accepted to play a role in controlling the affective state. Plant cannabinoids are well known to have behavioural effects in animals and humans and the cannabinoid CB1 receptor antagonist rimonabant has ...
Marsden, Charles A. +3 more
core +1 more source