Results 91 to 100 of about 6,428 (208)

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system [PDF]

, 2008
INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White, Francesca Lolli, Farkas, I., Amin, F., Mirjam Christ-Crain, Kola, Blerina, Fekete, Csaba, George Kunos, Kola, B., Faisal Amin, A. B. Grossman, M. Korbonits, Blerina Kola, Liposits, Zsolt, G. Kunos, Ashley B Grossman, B. Kola, Amin, F, Gábor Wittmann, Kunos, George, Christ-Crain, M, Farkas, Imre, Lolli, F, Zsolt Liposits, Lolli, F., F. Amin, Farkas, I, Christ-Crain, M., Korbonits, M., I. Farkas, Grossman, AB, C. Fekete, Kola, B, Harvey-White, J., Wittmann, Gábor, Korbonits, Márta, G. Wittmann, Harvey-White, J, Fekete, C, Harvey-White, Judith, Márta Korbonits, Imre Farkas, Liposits, Z, Z. Liposits, Grossman, Ashley B., Ashley B. Grossman, Wittmann, G., Christ-Crain, Mirjam, Amin, Faisal, Lolli, Francesca, Liposits, Z., M. Christ Crain, J. Harvey White, Fekete, C., Korbonits, M, Kunos, G., Csaba Fekete, Grossman, A. B., Kunos, G, Wittmann, G   +59 more
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Bioactivation of the Cannabinoid Receptor Antagonist Rimonabant to a Cytotoxic Iminium Ion Metabolite

, 2016
The cannabinoid type 1 receptor (CB1r) antagonist rimonabant was approved in 2006 for the treatment of obesity but was withdrawn in 2008 due to serious drug-related psychiatric disorders.
Lucy H. Prime (2001757), Frida Gustafsson (2001751), Emre M. Isin (1599604), J. Gerry Kenna (2001748), Alison J. Foster (2001754), David G. Temesi (2001739), Neal Castagnoli (2001745), Johanna Midlöv (2001742)   +7 more
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Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability [PDF]

, 2013
The cannabinoid 1 receptor antagonist rimonabant (SR141716) alters rewarding properties and intake of food and drugs. Additionally, striatal dopamine D2 receptor (DRD2) availability has been implicated in reward function.
van den Brink, W., Vanderschuren, Louk J. M. J., de Bruin, K., Booij, Jan, Booij, J., Schulz, S., de Bruin, Kora, Dep of Animals in Science and Society, Schulz, Sybille, van der Giessen, E., Emotion and Cognition, Vanderschuren, L.J.M.J., Crunelle, C.L., van de Giessen, Elsmarieke, van den Brink, Wim, Crunelle, Cleo L.   +15 more
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Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents

, 2009
The selective CB1 receptor antagonist rimonabant is a novel weight control agent. Although CB1 receptors and binding sites are present in both the rodent central and peripheral nervous systems, including the afferent vagus nerve, the role of gut ...
Larsen, Philip J, van de Wall, Esther H.E.M., Jelsing, Jacob, Schwartz, Gary J, Vrang, Niels, Madsen, Andreas Nygaard   +5 more
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Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a G alpha(i/o) protein inhibitor [PDF]

, 2018
Rimonabant is a potent and selective cannabinoid CB1 receptor antagonist widely used in animal and clinical studies. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse ...
M. Paola Castelli, M Paola Castelli, Melis, Miriam, Rostislav Turecek, Ignazia Mocci, Gessa, Gian Luigi, Gian Luigi Gessa, Castelli, M. Paola, Mocci, Ignazia, Bernhard Bettler, Celine Ullrich, Turecek, Rostislav, Porcu, Alessandra, Ullrich, Celine, Bettler, Bernhard, Alessandra Porcu, Miriam Melis   +16 more
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Rimonabant and synthesis of its 4-methylaminoderivative

, 2013
Předkládaná práce se zabývá vlastnostmi a syntézou účinné látky s triviálním názvem rimonabant, která byla v minulosti intenzivně studována především v souvislosti s léčbou obezity.
Kratochvílová, Eliška
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Modulation zentraler Sensibilisierungsvorgänge durch den selektiven CB1-Antagonisten Rimonabant [PDF]

, 2012
1 Background The application of cannabinoid agonists as analgesics in patients with neuropathic pain is currently a well-argued subject. Central sensitization due to chronic painful stimulation is thought to be an important factor in the pathogenesis of ...
Bürgel, Anna-Lena
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Antidepressant-like effects of Δ9-tetrahydrocannabinol and rimonabant in the olfactory bulbectomised rat model of depression [PDF]

, 2012
The endocannabinoid signalling system is widely accepted to play a role in controlling the affective state. Plant cannabinoids are well known to have behavioural effects in animals and humans and the cannabinoid CB1 receptor antagonist rimonabant has ...
Marsden, Charles A., Kendall, David A., Mohd Moklas, Mohamad Aris, Mohamed Elbatsh, Maha   +3 more
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RP-HPLC Method Development and Its Validation for Quantitative Determination of Rimonabant in Human Plasma

Journal of Analytical Methods in Chemistry, 2012
A simple, accurate, and precise HPLC method was developed and validated for determination of rimonabant in human plasma. Following liquid-liquid extraction, chromatographic separation was accomplished using C18 column with mobile phase consisting of ...
Shravan Bankey, Ganesh Tapadiya, Jasvant Lamale, Deepti Jain, Shweta Saboo, S. S. Khadabadi   +5 more
doaj   +1 more source

Antihyperlipidemic and Antiatherosclerotic Activity of Rimonabant in Wistar albino Rats

, 2020
The present study was carried out to investigate antihyperlipidemic and antiatherosclerotic effect of rimonabant against hyperlipidemia induced by high fat diet in wistar albino rats. Wistar albino rats were divided in 6 groups of 6 rats in each.
Ashish Mahajan, Praful Patel, Patil Sd
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