Results 81 to 90 of about 6,040 (212)
GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory
Comprehensive Physiology, Volume 16, Issue 2, April 2026.GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao +5 more
wiley +1 more source
, 2011 Aim: To investigate whether rimonabant, a cannabinoid receptor antagonist , had inhibitory effects on inflammatory reactions in human umbilical vein endothelial cells (HUVEC).
黃南嵐;莊志明;王怡和;薛嘉祥;梁耀仁;林俊立;蔡佳醍;賴凌平 +1 more
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Cost-Utility Analysis of Rimonabant in the Treatment of Obesity
, 2008 ObjectiveTo estimate the incremental cost-utility ratio (ICUR) of rimonabant 20 mg/day in the treatment of obesity from a third-party payer's perspective.MethodsPooled data from three randomized clinical trials were used to develop a decision tree with ...
Hampp, Christian +2 more
core +1 more source
Liver International, Volume 46, Issue 4, April 2026.ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Jerome Lian +3 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
Modern drugs for obesity and metabolic syndrome treatment (Review)
Сеченовский вестник, 2016 The article reviews modern anti-obesity drugs to identify new trends in effective and safe risk factors reduction (diabetes, cardiovascular and musculoskeletal diseases, cancer).
M. L. Maximov +4 more
doaj
Andrologia, Volume 2026, Issue 1, 2026.Introduction Cannabis is the most widely used drug in Morocco, particularly among young individuals, with potential repercussions on their reproductive health. Through its interaction with the endocannabinoid system, cannabis may interfere with spermatogenesis and hormonal regulation.
Adil Kbirou +6 more
wiley +1 more source
Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats
, 2010 The cannabinoid receptor 1 antagonist, rimonabant, reduces food intake and body weight, but contradictory findings have been reported as to whether the weight-reducing effect is fully accounted for by the reduced food intake or if rimonabant also ...
Malmlöf, Kjell, +1 more
core +2 more sources
Rimonabant ยาใหม่เพอื่ ลดความเสี่ยงในระบบหัวใจและเมแทบอลิก
, 2008 การศึกษายาใหม่เพื่อป้องกันและรักษาโรคทางหัวใจและเมแทบอลิก (cardiometabolic diseases) ให้มีประสิทธิภาพดียิ่งขึ้นดำเนินต่อไป เพื่อลดปัจจัยเสี่ยงที่จะนำไปสู่การเกิด cardiometabolic diseases ยา rimonabant จัดเป็นยาตัวแรกในกลุ่ม cannabinoid1antagonist (CB1 ...
พันธุเวทย์, วิมล
core
Rimonabant improves hepatic steatosis in OLETF rats.
, 2018 (A) Representative hematoxylin and eosin-stained liver sections (scale bars, 200 μm; magnification, 200 X). (B) NAFLD activity score. Representative images of Masson’s trichrome staining (C; scale bars, 100 μm; magnification, 400 X) and fibrosis score (D)
Hyekyung Yang (2461081) +5 more
core +1 more source