Results 21 to 30 of about 4,732 (172)

Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats Comparação do efeito do rimonabanto e da sibutramina no tratamento da compulsão alimentar em ratos

Acta Cirúrgica Brasileira, 2009
PURPOSE: To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine. METHODS: It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats,
Honório Sampaio Menezes, Verônica Ciulla, Paulo Sampaio Camargo, Cora Albrecht Correa, Tatiana Medina Costa de Oliveira   +4 more
doaj   +1 more source

Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids

Frontiers in Pharmacology, 2018
Colorectal cancer (CRC), like other tumor types, is a highly heterogeneous disease. Within the tumor bulk, intra-tumoral heterogeneity is also ascribable to Cancer Stem Cells (CSCs) subpopulation, characterized by high chemoresistance and the unique ...
Donatella Fiore, Prashanthi Ramesh, Maria C. Proto, Chiara Piscopo, Silvia Franceschelli, Serena Anzelmo, Jan P. Medema, Maurizio Bifulco, Patrizia Gazzerro   +8 more
doaj   +1 more source

Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge

Cells, 2022
Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders (SUDs). Early studies indicated that rimonabant, a selective CB1R antagonist with an inverse agonist profile, was highly ...
Omar Soler-Cedeno, Zheng-Xiong Xi
doaj   +1 more source

Systematic review and meta-analysis on the adverse events of rimonabant treatment: Considerations for its potential use in hepatology

BMC Gastroenterology, 2009
Background The cannabinoid-1 receptor blockers have been proposed in the management of obesity and obesity-related liver diseases (fatty liver as NAFLD or NASH).
Crocè Lory S, Bedogni Giorgio, Tellez-Avila Felix I, Chavez-Tapia Norberto C, Masutti Flora, Tiribelli Claudio   +5 more
doaj   +1 more source

The endocanabinnoid system and diabetes - critical analyses of studies conducted with rimonabant

Diabetology & Metabolic Syndrome, 2009
Rimonabant is the first CB1 receptor inhibitor available in the Brazilian market. This new drug has been approved for the treatment of obese or overweight patients associated with cardiovascular risk factors. In this article it is compared the effects of
Murro Ada
doaj   +1 more source

Veraliprida y rimonabant

Evidencia. Actualización en la Práctica Ambulatoria, 2007
Flavia Vidal
doaj   +3 more sources

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice

Journal of Lipid Research, 2021
Pharmacological blockade of the cannabinoid type 1 receptor, a G protein-coupled receptor expressed in the central nervous system and various peripheral tissues, reverses diet-induced obesity and dyslipidemia through the reduction of food intake and ...
Robin van Eenige, Zhixiong Ying, Lauren Tambyrajah, Amanda C.M. Pronk, Niek Blomberg, Martin Giera, Yanan Wang, Tamer Coskun, Mario van der Stelt, Patrick C.N. Rensen, Sander Kooijman   +10 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Psychosocial stress and cannabinoid drugs affect acetylation of α-tubulin (K40) and gene expression in the prefrontal cortex of adult mice

PLoS ONE, 2022
The dynamics of neuronal microtubules are essential for brain plasticity. Vesicular transport and synaptic transmission, additionally, requires acetylation of α-tubulin, and aberrant tubulin acetylation and neurobiological deficits are associated ...
Jordi Tomas-Roig, Shyam Ramasamy, Diana Zbarsky, Ursula Havemann-Reinecke, Sigrid Hoyer-Fender   +4 more
doaj   +2 more sources

The role of exercise training and the endocannabinoid system in atherosclerotic plaque burden and composition in Apo-E-deficient mice

Hellenic Journal of Cardiology, 2016
Introduction: We investigated the effect of combining exercise training and treatment with an endocannabinoid receptor 1 inhibitor (Rimonabant) on atherosclerosis burden and composition. Methods: Forty-eight apolipoprotein E-deficient (ApoE-/-) mice were
Michalis Katsimpoulas, Nikolaos E. Kadoglou, Petros Moustardas, Alkistis Kapelouzou, Eleni Dede, Nikolaos Kostomitsopoulos, Panayotis E. Karayannacos, Alkiviadis Kostakis, Christos D. Liapis   +8 more
doaj   +1 more source