Results 21 to 30 of about 6,040 (212)
Molecules, 2021 Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments.
Luis Santos-Molina +10 more
doaj +1 more source
Combining rimonabant and fentanyl in a single entity: Preparation and pharmacological results [PDF]
, 2014 Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared by coupling the molecular ...
Erdozain, Amaia M +23 more
core +1 more source
Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia
Journal of Obesity, 2011 Rimonabant, a selective cannabinoid-1 (CB1) receptor antagonist, has been shown to reduce weight and enhance improvements in cardiometabolic risk parameters in Western populations. This study assessed these effects of rimonabant in Asian population.
Changyu Pan, Hyung Joon Yoo, Low-Tone Ho
doaj +1 more source
Fatty acid flux and oxidation are increased by rimonabant in obese women. [PDF]
, 2012 This study aimed to determine in obese women if endocannabinoid receptor antagonism has effects on fatty acid and triglyceride metabolism and insulin sensitivity which are independent from the metabolic effects of weight loss.
Backhouse, Katharine +26 more
core +1 more source
Frontiers in Pharmacology, 2019 Rimonabant was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was withdrawn from market due to the notably increased rates of psychiatric side effects.
Vincenzo Micale +6 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of opioids, studies suggest that the treatment ...
Eduardo A. V. Marinho +12 more
doaj +1 more source
Acta Cirúrgica Brasileira, 2009 PURPOSE: To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine. METHODS: It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats,
Honório Sampaio Menezes +4 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring.
Yuxiao Wan +3 more
doaj +1 more source
Drugs and Drug Candidates, 2023 The endocannabinoid system is found throughout the CNS and the body where it impacts many important physiological processes. Expectations were high that targeting cannabinoid receptors would prove therapeutically beneficial; pharmaceutical companies ...
Taryn Bosquez-Berger +2 more
doaj +1 more source
Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids
Frontiers in Pharmacology, 2018 Colorectal cancer (CRC), like other tumor types, is a highly heterogeneous disease. Within the tumor bulk, intra-tumoral heterogeneity is also ascribable to Cancer Stem Cells (CSCs) subpopulation, characterized by high chemoresistance and the unique ...
Donatella Fiore +8 more
doaj +1 more source