Results 31 to 40 of about 6,428 (208)

Systematic review and meta-analysis on the adverse events of rimonabant treatment: Considerations for its potential use in hepatology

BMC Gastroenterology, 2009
Background The cannabinoid-1 receptor blockers have been proposed in the management of obesity and obesity-related liver diseases (fatty liver as NAFLD or NASH).
Crocè Lory S, Bedogni Giorgio, Tellez-Avila Felix I, Chavez-Tapia Norberto C, Masutti Flora, Tiribelli Claudio   +5 more
doaj   +1 more source

The endocanabinnoid system and diabetes - critical analyses of studies conducted with rimonabant

Diabetology & Metabolic Syndrome, 2009
Rimonabant is the first CB1 receptor inhibitor available in the Brazilian market. This new drug has been approved for the treatment of obese or overweight patients associated with cardiovascular risk factors. In this article it is compared the effects of
Murro Ada
doaj   +1 more source

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice

Journal of Lipid Research, 2021
Pharmacological blockade of the cannabinoid type 1 receptor, a G protein-coupled receptor expressed in the central nervous system and various peripheral tissues, reverses diet-induced obesity and dyslipidemia through the reduction of food intake and ...
Robin van Eenige, Zhixiong Ying, Lauren Tambyrajah, Amanda C.M. Pronk, Niek Blomberg, Martin Giera, Yanan Wang, Tamer Coskun, Mario van der Stelt, Patrick C.N. Rensen, Sander Kooijman   +10 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Psychosocial stress and cannabinoid drugs affect acetylation of α-tubulin (K40) and gene expression in the prefrontal cortex of adult mice

PLoS ONE, 2022
The dynamics of neuronal microtubules are essential for brain plasticity. Vesicular transport and synaptic transmission, additionally, requires acetylation of α-tubulin, and aberrant tubulin acetylation and neurobiological deficits are associated ...
Jordi Tomas-Roig, Shyam Ramasamy, Diana Zbarsky, Ursula Havemann-Reinecke, Sigrid Hoyer-Fender   +4 more
doaj   +2 more sources

The role of exercise training and the endocannabinoid system in atherosclerotic plaque burden and composition in Apo-E-deficient mice

Hellenic Journal of Cardiology, 2016
Introduction: We investigated the effect of combining exercise training and treatment with an endocannabinoid receptor 1 inhibitor (Rimonabant) on atherosclerosis burden and composition. Methods: Forty-eight apolipoprotein E-deficient (ApoE-/-) mice were
Michalis Katsimpoulas, Nikolaos E. Kadoglou, Petros Moustardas, Alkistis Kapelouzou, Eleni Dede, Nikolaos Kostomitsopoulos, Panayotis E. Karayannacos, Alkiviadis Kostakis, Christos D. Liapis   +8 more
doaj   +1 more source

Obesity, the endocannabinoid system, and bias arising from pharmaceutical sponsorship. [PDF]

PLoS ONE, 2009
Previous research has shown that academic physicians conflicted by funding from the pharmaceutical industry have corrupted evidence based medicine and helped enlarge the market for drugs.
John M McPartland
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Reducing Effect of Saikosaponin A, an Active Ingredient of Bupleurum falcatum, on Intake of Highly Palatable Food in a Rat Model of Overeating

Frontiers in Psychiatry, 2018
Recent lines of experimental evidence have indicated that saikosaponin A (SSA)—a bioactive ingredient of the medicinal plant, Bupleurum falcatum L.—potently and effectively reduced operant self-administration of chocolate and reinstatement of chocolate ...
Paola Maccioni, Federica Fara, Gian Luigi Gessa, Mauro A. M. Carai, Young-Won Chin, Jung Hwan Lee, Hak Cheol Kwon, Giancarlo Colombo   +7 more
doaj   +1 more source

The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake. [PDF]

PLoS ONE, 2013
Over the years, the knowledge regarding the relevance of the cannabinoid system to the regulation of metabolism has grown steadily. A central interaction between the cannabinoid system and ghrelin has been suggested to regulate food intake.
Lucia L Senin, Omar Al-Massadi, Cintia Folgueira, Cecilia Castelao, Maria Pardo, Silvia Barja-Fernandez, Arturo Roca-Rivada, Maria Amil, Ana B Crujeiras, Tomas Garcia-Caballero, Enrico Gabellieri, Rosaura Leis, Carlos Dieguez, Uberto Pagotto, Felipe F Casanueva, Luisa M Seoane   +15 more
doaj   +1 more source