Results 31 to 40 of about 6,040 (212)

Veraliprida y rimonabant

Evidencia. Actualización en la Práctica Ambulatoria, 2007
Flavia Vidal
doaj   +3 more sources

Rimonabant [PDF]

pharma-kritik, 2007
Ein Cannabinoid-Rezeptorblocker, der bei Adipösen die Gewichtsabnahme begünstigt. Ein Nutzen bei anderen Indikationen konnte bisher nicht gezeigt werden. Die Substanz kann verschiedene neuropsychiatrische Nebenwirkungen verursachen.
openaire   +1 more source

Systematic review and meta-analysis on the adverse events of rimonabant treatment: Considerations for its potential use in hepatology

BMC Gastroenterology, 2009
Background The cannabinoid-1 receptor blockers have been proposed in the management of obesity and obesity-related liver diseases (fatty liver as NAFLD or NASH).
Crocè Lory S, Bedogni Giorgio, Tellez-Avila Felix I, Chavez-Tapia Norberto C, Masutti Flora, Tiribelli Claudio   +5 more
doaj   +1 more source

The endocanabinnoid system and diabetes - critical analyses of studies conducted with rimonabant

Diabetology & Metabolic Syndrome, 2009
Rimonabant is the first CB1 receptor inhibitor available in the Brazilian market. This new drug has been approved for the treatment of obese or overweight patients associated with cardiovascular risk factors. In this article it is compared the effects of
Murro Ada
doaj   +1 more source

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.

, 2008
OBJECTIVE Blockade of the CB1 receptor is one of the promising strategies for the treatment of obesity. Although antagonists suppress food intake and reduce body weight, the role of central versus peripheral CB1 activation on weight loss and related ...
Nogueiras, Ruben, Klein, Marcella, Liposits, Zsolt, Tschöp, Matthias H., Watanabe, Masahiko, Rohner-Jeanrenaud, Francoise, Wittmann, Gábor, Veyrat-Durebex, Christelle, Tschöp, Johannes, Fekete, Csaba, Reizes, Ofer, Woods, Stephen C., Suchanek, Paula M., Caldwell, Charles   +13 more
core   +1 more source

Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE∗3-Leiden.CETP mice

Journal of Lipid Research, 2021
Pharmacological blockade of the cannabinoid type 1 receptor, a G protein-coupled receptor expressed in the central nervous system and various peripheral tissues, reverses diet-induced obesity and dyslipidemia through the reduction of food intake and ...
Robin van Eenige, Zhixiong Ying, Lauren Tambyrajah, Amanda C.M. Pronk, Niek Blomberg, Martin Giera, Yanan Wang, Tamer Coskun, Mario van der Stelt, Patrick C.N. Rensen, Sander Kooijman   +10 more
doaj   +1 more source

The role of exercise training and the endocannabinoid system in atherosclerotic plaque burden and composition in Apo-E-deficient mice

Hellenic Journal of Cardiology, 2016
Introduction: We investigated the effect of combining exercise training and treatment with an endocannabinoid receptor 1 inhibitor (Rimonabant) on atherosclerosis burden and composition. Methods: Forty-eight apolipoprotein E-deficient (ApoE-/-) mice were
Michalis Katsimpoulas, Nikolaos E. Kadoglou, Petros Moustardas, Alkistis Kapelouzou, Eleni Dede, Nikolaos Kostomitsopoulos, Panayotis E. Karayannacos, Alkiviadis Kostakis, Christos D. Liapis   +8 more
doaj   +1 more source

Obesity, the endocannabinoid system, and bias arising from pharmaceutical sponsorship. [PDF]

PLoS ONE, 2009
Previous research has shown that academic physicians conflicted by funding from the pharmaceutical industry have corrupted evidence based medicine and helped enlarge the market for drugs.
John M McPartland
doaj   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Psychosocial stress and cannabinoid drugs affect acetylation of α-tubulin (K40) and gene expression in the prefrontal cortex of adult mice

PLoS ONE, 2022
The dynamics of neuronal microtubules are essential for brain plasticity. Vesicular transport and synaptic transmission, additionally, requires acetylation of α-tubulin, and aberrant tubulin acetylation and neurobiological deficits are associated ...
Jordi Tomas-Roig, Shyam Ramasamy, Diana Zbarsky, Ursula Havemann-Reinecke, Sigrid Hoyer-Fender   +4 more
doaj   +2 more sources