Results 11 to 20 of about 6,040 (212)
Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review. [PDF]
MicrocirculationABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Matias EF +2 more
europepmc +2 more sources
CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes. [PDF]
PLoS ONE, 2018 Previous studies have shown that the CB1 receptor antagonist reverses steatohepatitis and its related features of metabolic syndrome, such as obesity and type 2 diabetes.
Eugene Chang +5 more
doaj +1 more source
Potential Implications of Rimonabant on Age-Related Oxidative Stress and Inflammation
Antioxidants, 2022 Over the last decades, growing interest has turned to preventive and therapeutic approaches for achieving successful aging. Oxidative stress and inflammation are fundamental features of cardiovascular diseases; therefore, potential targets of them can ...
Renáta Szabó +14 more
doaj +1 more source
Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice. [PDF]
PLoS ONE, 2011 Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes.
Chunxiu Hu +13 more
doaj +1 more source
Molecules, 2020 (1) Background: Acute administration of the cannabinoid receptor 1 (CB1R) inverse agonist Rimonabant (SR141716A) to fed Wistar rats was shown to elicit a rapid and short-lasting elevation of serum free fatty acids.
Günter A. Müller +3 more
doaj +1 more source
The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
Pathophysiology, 2021 Cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two G-protein-coupled cannabinoid receptors, CB1 and CB2.
Mansour Haddad
doaj +1 more source
Neurobiology of Disease, 2007 Preclinical and clinical research shows that the cannabinoid brain receptor type 1 (CB1) modulates alcohol- and nicotine-related behaviors. Throughout the nicotine-induced relapse to alcohol, the rats were pre-treated for 10 days with the CB1 cannabinoid
José Antonio López-Moreno +2 more
doaj +1 more source
Cells, 2022 Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders (SUDs). Early studies indicated that rimonabant, a selective CB1R antagonist with an inverse agonist profile, was highly ...
Omar Soler-Cedeno, Zheng-Xiong Xi
doaj +1 more source
Depression-like phenotype following chronic CB1 receptor antagonism
Neurobiology of Disease, 2010 Rimonabant was the first clinically marketed cannabinoid (CB)1 receptor antagonist developed to treat obesity. Unfortunately, CB1 receptor antagonism produced adverse psychiatric events in patients.
Chad E. Beyer +11 more
doaj +1 more source
Effects of Combined Oleoyl-Estrone and Rimonabant on Overweight Rats
Journal of Pharmacological Sciences, 2007 Oleoyl-estrone (OE) decreases appetite, maintains energy expediture, induces lipolysis (sparing protein), and decreases cholesterolemia and insulin resistance.
Raquel Ferrer-Lorente +3 more
doaj +1 more source