Results 11 to 20 of about 4,732 (172)
Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review. [PDF]
MicrocirculationABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Matias EF +2 more
europepmc +2 more sources
Frontiers in Pharmacology, 2023 Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of opioids, studies suggest that the treatment ...
Eduardo A. V. Marinho +12 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring.
Yuxiao Wan +3 more
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Depression-like phenotype following chronic CB1 receptor antagonism
Neurobiology of Disease, 2010 Rimonabant was the first clinically marketed cannabinoid (CB)1 receptor antagonist developed to treat obesity. Unfortunately, CB1 receptor antagonism produced adverse psychiatric events in patients.
Chad E. Beyer +11 more
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Drugs and Drug Candidates, 2023 The endocannabinoid system is found throughout the CNS and the body where it impacts many important physiological processes. Expectations were high that targeting cannabinoid receptors would prove therapeutically beneficial; pharmaceutical companies ...
Taryn Bosquez-Berger +2 more
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pharma-kritik, 2007 Ein Cannabinoid-Rezeptorblocker, der bei Adipösen die Gewichtsabnahme begünstigt. Ein Nutzen bei anderen Indikationen konnte bisher nicht gezeigt werden. Die Substanz kann verschiedene neuropsychiatrische Nebenwirkungen verursachen.
openaire +1 more source
Effects of Combined Oleoyl-Estrone and Rimonabant on Overweight Rats
Journal of Pharmacological Sciences, 2007 Oleoyl-estrone (OE) decreases appetite, maintains energy expediture, induces lipolysis (sparing protein), and decreases cholesterolemia and insulin resistance.
Raquel Ferrer-Lorente +3 more
doaj +1 more source
Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia
Journal of Obesity, 2011 Rimonabant, a selective cannabinoid-1 (CB1) receptor antagonist, has been shown to reduce weight and enhance improvements in cardiometabolic risk parameters in Western populations. This study assessed these effects of rimonabant in Asian population.
Changyu Pan, Hyung Joon Yoo, Low-Tone Ho
doaj +1 more source
Frontiers in Pharmacology, 2019 Rimonabant was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was withdrawn from market due to the notably increased rates of psychiatric side effects.
Vincenzo Micale +6 more
doaj +1 more source
Molecules, 2021 Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments.
Luis Santos-Molina +10 more
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