Results 11 to 20 of about 40,137 (231)

An enquiry to the role of CB1 receptors in neurodegeneration

Neurobiology of Disease, 2023
Neurodegenerative disorders are debilitating conditions that impair patient quality of life and that represent heavy social-economic burdens to society. Whereas the root of some of these brain illnesses lies in autosomal inheritance, the origin of most of these neuropathologies is scantly understood.
Fernandez-Moncada, Ignacio, Eraso-Pichot, Abel, Dalla Tor, Tommaso, Fortunato-Marsol, Berenice, Marsicano, Giovanni   +4 more
openaire   +4 more sources

Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales. [PDF]

, 2007
[spa] La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden
Carriba Domínguez, Paulina
core   +6 more sources

(+)-Trans-Cannabidiol Is an Agonist at Human CB₂ Receptors. [PDF]

Pharmacol Res Perspect
ABSTRACT (−)‐trans‐Cannabidiol ((−)‐CBD) is a principal phytocannabinoid from Cannabis sativa. (−)‐CBD has complex pharmacology but is a relatively weak inhibitor of CB1 and CB2 receptor signaling. Cannabidiol has two chiral centres and thus four stereoisomers.
Burtchaell PB, Santiago MJ, Wang C, Hagdoost M, Clay EJM, Mohnot D, Connor M.   +6 more
europepmc   +2 more sources

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. [PDF]

, 2008
OBJECTIVE Blockade of the CB1 receptor is one of the promising strategies for the treatment of obesity. Although antagonists suppress food intake and reduce body weight, the role of central versus peripheral CB1 activation on weight loss and related ...
Nogueiras, Ruben, Klein, Marcella, Liposits, Zsolt, Tschöp, Matthias H., Watanabe, Masahiko, Rohner-Jeanrenaud, Francoise, Wittmann, Gábor, Veyrat-Durebex, Christelle, Tschöp, Johannes, Fekete, Csaba, Reizes, Ofer, Woods, Stephen C., Suchanek, Paula M., Caldwell, Charles   +13 more
core   +3 more sources

Cannabinoid CB₁ allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression. [PDF]

Br J Pharmacol
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Solomon ID, Garai S, Thakur GA, Hohmann AG.   +3 more
europepmc   +2 more sources

Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNA ameliorates hepatic fibrosis in rats. [PDF]

PLoS ONE, 2012
It is recognized that endogenous cannabinoids, which signal through CB1 receptors in hepatic stellate cells (HSCs), exert a profibrotic effect on chronic liver diseases. In this study, we suppressed CB1 expression by lentivirus mediated small interfering
Si-Wen Chen, Ben-Yan Wu, Shi-Ping Xu, Ke-Xing Fan, Li Yan, Yuan Gong, Jun-Bao Wen, Dao-Hong Wu   +7 more
doaj   +1 more source

Cannabinoid CB1 receptor expression in oligodendrocyte progenitors of the hippocampus revealed by the NG2-EYFP-knockin mouse

Frontiers in Neuroanatomy, 2022
Adult oligodendrocyte progenitor cells (OPCs) give rise to myelinating oligodendrocytes through life and play crucial roles in brain homeostasis and plasticity during health and disease.
Andrea Manterola, Andrea Manterola, Andrea Manterola, Juan Carlos Chara, Juan Carlos Chara, Juan Carlos Chara, Tania Aguado, Tania Aguado, Tania Aguado, Javier Palazuelos, Javier Palazuelos, Javier Palazuelos, Carlos Matute, Carlos Matute, Carlos Matute, Susana Mato, Susana Mato, Susana Mato, Susana Mato   +18 more
doaj   +1 more source

Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol

Arhiv za Higijenu Rada i Toksikologiju, 2020
Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. The effects of cannabinoids therefore differ not just because
Černe Katarina
doaj   +1 more source

Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex

Molecules, 2021
Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational principles of plasma ...
Miquel Saumell-Esnaola, Sergio Barrondo, Gontzal García del Caño, María Aranzazu Goicolea, Joan Sallés, Beat Lutz, Krisztina Monory   +6 more
doaj   +1 more source

The CB1 Receptor as the Cornerstone of Exostasis [PDF]

Neuron, 2017
The type-1 cannabinoid receptor (CB1) is the main effector of the endocannabinoid system (ECS), which is involved in most brain and body functions. In this Perspective, we provide evidence indicating that CB1 receptor functions are key determinants of bodily coordinated exostatic processes.
Pier Vincenzo Piazza, Daniela Cota, Giovanni Marsicano   +2 more
openaire   +2 more sources