Results 11 to 20 of about 36,753 (242)
An enquiry to the role of CB1 receptors in neurodegeneration
Neurobiology of Disease, 2023 Neurodegenerative disorders are debilitating conditions that impair patient quality of life and that represent heavy social-economic burdens to society. Whereas the root of some of these brain illnesses lies in autosomal inheritance, the origin of most of these neuropathologies is scantly understood.
Fernandez-Moncada, Ignacio +4 more
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CB1 Cannabinoid Receptor Signaling and Biased Signaling
Molecules, 2021 The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration.
Luciana M. Leo, Mary E. Abood
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Cell Death Discovery, 2022 Cannabinoid receptors, CB1 and CB2, have been implicated as emerging targets for cancer therapy. Herein, we investigated the potential regulation mechanism of CB1 and its implications in colorectal cancer.
You-Ming Deng +4 more
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Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]
PLoS ONE, 2014 Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow +5 more
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High spatio-temporal resolution pollutant measurements of on-board vehicle emissions using ultra-fast response gas analyzers [PDF]
Atmospheric Measurement Techniques, 2018 Existing ultra-fast response engine exhaust emissions analyzers have been adapted for on-board vehicle use combined with GPS data. We present, for the first time, how high spatio-temporal resolution data products allow transient features associated ...
M. Irwin +5 more
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The CB1 Receptor as the Cornerstone of Exostasis [PDF]
Neuron, 2017 The type-1 cannabinoid receptor (CB1) is the main effector of the endocannabinoid system (ECS), which is involved in most brain and body functions. In this Perspective, we provide evidence indicating that CB1 receptor functions are key determinants of bodily coordinated exostatic processes.
Pier Vincenzo Piazza +2 more
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Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNA ameliorates hepatic fibrosis in rats. [PDF]
PLoS ONE, 2012 It is recognized that endogenous cannabinoids, which signal through CB1 receptors in hepatic stellate cells (HSCs), exert a profibrotic effect on chronic liver diseases. In this study, we suppressed CB1 expression by lentivirus mediated small interfering
Si-Wen Chen +7 more
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The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra. [PDF]
PLoS ONE, 2018 Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum and substantia nigra, where they play a role in learning ...
Margaret I Davis +7 more
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Frontiers in Neuroanatomy, 2022 Adult oligodendrocyte progenitor cells (OPCs) give rise to myelinating oligodendrocytes through life and play crucial roles in brain homeostasis and plasticity during health and disease.
Andrea Manterola +18 more
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Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol
Arhiv za Higijenu Rada i Toksikologiju, 2020 Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. The effects of cannabinoids therefore differ not just because
Černe Katarina
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