Results 31 to 40 of about 36,753 (242)

Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration

Frontiers in Physiology, 2016
The cannabinoid type 1 (CB1) receptor is widely distributed in the brain and peripheral organs where it regulates cellular functions and metabolism. In the brain, CB1 is mainly localized on presynaptic axon terminals but is also found on mitochondria ...
Juan Mendizabal-Zubiaga, Juan Mendizabal-Zubiaga, Su Melser, Su Melser, Giovanni Bénard, Almudena Ramos, Almudena Ramos, Giovanni Bénard, Leire Reguero, Leire Reguero, Sergio Arrabal, Izaskun Elezgarai, Izaskun Elezgarai, Inmaculada Gerrikagoitia, Inmaculada Gerrikagoitia, Juan Suárez, Fernando Rodríguez de Fonseca, Nagore Puente, Nagore Puente, Giovanni Marsicano, Giovanni Marsicano, Pedro Grandes, Pedro Grandes, Pedro Grandes   +23 more
doaj   +1 more source

The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells

Pathophysiology, 2021
Cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two G-protein-coupled cannabinoid receptors, CB1 and CB2.
Mansour Haddad
doaj   +1 more source

Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders

Clinical, Cosmetic and Investigational Dermatology, 2020
Sudhir M Baswan,1,* Allison E Klosner,2,* Kelly Glynn,1 Arun Rajgopal,1 Kausar Malik,1 Sunghan Yim,1 Nathan Stern1 1Innovation and Science, Amway Corporation, Ada, MI, 49355, USA; 2Innovation and Science, Nutrilite Health Institute, Amway Corporation ...
Baswan SM, Klosner AE, Glynn K, Rajgopal A, Malik K, Yim S, Stern N   +6 more
doaj  

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.

, 2008
OBJECTIVE Blockade of the CB1 receptor is one of the promising strategies for the treatment of obesity. Although antagonists suppress food intake and reduce body weight, the role of central versus peripheral CB1 activation on weight loss and related ...
Nogueiras, Ruben, Klein, Marcella, Liposits, Zsolt, Tschöp, Matthias H., Watanabe, Masahiko, Rohner-Jeanrenaud, Francoise, Wittmann, Gábor, Veyrat-Durebex, Christelle, Tschöp, Johannes, Fekete, Csaba, Reizes, Ofer, Woods, Stephen C., Suchanek, Paula M., Caldwell, Charles   +13 more
core   +1 more source

Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease

, 2014
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
Silvia Cianci, ROMANO, ADELE, Romano, A, M. r. Elphick, Gianluigi Vendemiale, Pace, Lorenzo, Elphick, Maurice R, Bedse, G, Angelo M. Lavecchia, Gaurav Bedse, GAETANI, SILVANA, VENDEMIALE, GIANLUIGI, LAVECCHIA, ANGELO MICHELE, @CORRESPONDING AUTHOR, Vendemiale, G, CIANCI, SILVIA, Pace Lorenzo, Lorenzo Federico Pace, Adele Romano, Gaetani, S, Tommaso Cassano, BEDSE, GAURAV, Lorenzo, P, Caterina Grillo, Cassano, T, Grillo, C, Laferla, Frank M, ALTIERI, Fabio, Elphick, MR, LaFerla, FM, Maurice R. Elphick, GRILLO, CATERINA, Silvana Gaetani, Frank M. LaFerla, F. m. Laferla, CASSANO, TOMMASO, Lavecchia, AM, Fabio Altieri, Altieri, F, Cianci, S   +39 more
core   +1 more source

Profile of the breast cancer susceptibility marker rs4245739 identifies a role for miRNAs

Cancer Biology & Medicine, 2017
Objective: To determine the influence of the single nucleotide polymorphism (SNP) rs4245739 on the binding and expression of microRNAs and subsequent MDM4 expression and the correlation of these factors with clinical determinants of ER-negative breast ...
Sumadi Lukman Anwar, Wahyu Wulaningsih, Johnathan Watkins   +2 more
doaj   +1 more source

Flexibility in assessment of rare disease technologies via NICE’s single technology appraisal route: a thematic analysis

Journal of Comparative Effectiveness Research, 2023
Aim: NICE’s highly specialized technology (HST) evaluations are highly restrictive in terms of entry criteria and as a consequence, the vast majority of rare disease medicines are assessed through NICE’s standard, single technology appraisal (STA ...
George Hale, James Morris, Jules Barker-Yip   +2 more
doaj   +1 more source

Prediction of essential binding domains for the endocannabinoid N-arachidonoylethanolamine (AEA) in the brain cannabinoid CB1 receptor.

PLoS ONE, 2021
Δ9-tetrahydrocannabinol (Δ9-THC), the main active ingredient of Cannabis sativa (marijuana), interacts with the human brain cannabinoid (CB1) receptor and mimics pharmacological effects of endocannabinoids (eCBs) like N-arachidonylethanolamide (AEA). Due
Joong-Youn Shim
doaj   +1 more source

Cannabinoid CB1 receptor [PDF]

Science-Business eXchange, 2008
  +12 more sources

Signal transduction of the CB1 cannabinoid receptor [PDF]

Journal of Molecular Endocrinology, 2009
The CB1 cannabinoid receptor (CB1R) is the major cannabinoid receptor in neuronal cells and the brain, but it also occurs in endocrine cells and other peripheral tissues. CB1R is a member of the superfamily of G-protein-coupled receptors (GPCRs), which are characterized by seven transmembrane helices.
Gábor, Turu, László, Hunyady
openaire   +2 more sources