Results 51 to 60 of about 36,753 (242)

CB1 RECEPTOR

, 2021
CBD analogues with CB1 ...
Neyder Contreras-Puentes (6900158)
core   +1 more source

Differential expression of brain cannabinoid receptors between repeatedly stressed males and females may play a role in age and gender-related difference in traumatic brain injury: Implications from animal studies

Frontiers in Neurology, 2014
Inconsistent gender differences in the outcome of TBI have been reported. The mechanism is unknown. In a recent male animal study, repeated stress followed by TBI had synergistic effects on brain gene expression and caused greater behavioral deficits ...
Guoqiang eXing, Guoqiang eXing, Janis eCarlton, Xiaolong eJiang, Jillian eWen, Jillian eWen, Min eJia, He eLi   +7 more
doaj   +1 more source

‘School is their whole world’: Teachers' perspectives on loneliness among children and adolescents from England and mainland China

British Educational Research Journal, EarlyView.
Abstract As front‐line observers and active participants in pupils' daily lives, teachers closely monitor pupils' social interactions, emotional states and behavioural changes. Their unique perspective enables them to detect problems in the social lives of their pupils that may not be immediately visible to peers, parents or mental health professionals.
Yixuan Zheng, Charlotte Bagnall, Caroline Bond, Elizabeth Birchinall, Pamela Qualter   +4 more
wiley   +1 more source

Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats

BMC Urology, 2017
Background This study investigated changes in the expression of cannabinoid (CB) receptors and the effects of CB1 and CB2 agonists on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO) in rats.
Sung Dae Kim, Kang Jun Cho, Joon Chul Kim   +2 more
doaj   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source

Recent trends in studying of alcohol-induced liver disease

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2011
The aim of review. To analyze main epidemiologic tendencies of development of alcoholic liver disease, mechanisms of its development, mortality in this population of patients.
I. I. Komkova, M. S. Zharkova, M. V. Mayevskaya   +2 more
doaj  

RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors. [PDF]

PLoS Genetics, 2017
In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators.
Claire de Groot, Amalia Floriou-Servou, Yuan-Chen Tsai, Simon Früh, Manuela Kohler, Georgia Parkin, Cornelia Schwerdel, Giovanna Bosshard, Kai Kaila, Jean-Marc Fritschy, Shiva K Tyagarajan   +10 more
doaj   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Effect of CB1 Receptor Deficiency on Mitochondrial Quality Control Pathways in Gastrocnemius Muscle

Biology
This study aims to explore the complex role of cannabinoid type 1 receptor (CB1) signaling in the gastrocnemius muscle, assessing physiological processes in both CB1+/+ and CB1−/− mice.
Rosalba Senese, Giuseppe Petito, Elena Silvestri, Maria Ventriglia, Nicola Mosca, Nicoletta Potenza, Aniello Russo, Francesco Manfrevola, Gilda Cobellis, Teresa Chioccarelli, Veronica Porreca, Vincenza Grazia Mele, Rosanna Chianese, Pieter de Lange, Giulia Ricci, Federica Cioffi, Antonia Lanni   +16 more
doaj   +1 more source

Metabolic Profiling of CB1 Neutral Antagonists [PDF]

, 2017
PIMSR is among the first neutral antagonists for the CB1R and was demonstrated pharmacologically to bind to the CB1R, yet not alter calcium flux. It was further shown computationally to be able to stabilize both the active and inactive states of CB1R revealing the molecular interactions that mechanistically afford the property of neutral antagonism ...
Herbert H, Seltzman, Rangan, Maitra, Katharine, Bortoff, Jay, Henson, Patricia H, Reggio, Daniel, Wesley, Joseph, Tam   +6 more
openaire   +2 more sources