Results 41 to 50 of about 59,314 (277)

Cannabinoid CB1 Receptor Calibrates Excitatory Synaptic Balance in the Mouse Hippocampus

Journal of Neuroscience, 2015
The endocannabinoid system negatively regulates the release of various neurotransmitters in an activity-dependent manner, thereby influencing the excitability of neuronal circuits.
K. Monory, M. Polack, Anita Remus, B. Lutz, M. Korte   +4 more
semanticscholar   +1 more source

The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects [PDF]

, 2015
Funded by: •GW Pharmaceuticals Acknowledgements: The authors wish to thank Mrs Lesley Stevenson for technical support and Dr John Raymond, Dr Keith Parker and Dr Ethan Russo for providing human 5-HT1A CHO cells.
Cascio, Maria Grazia, Marini, Pietro, Parolaro, Daniela, Pertwee, Roger G., Zamberletti, Erica   +4 more
core   +1 more source

New Perspectives in the Studies on Endocannabinoid and Cannabis: Cannabinoid Receptors and Schizophrenia

Journal of Pharmacological Sciences, 2004
Cannabis consumption may induce psychotic states in normal individuals, worsen psychotic symptoms of schizophrenic patients, and may facilitate precipitation of schizophrenia in vulnerable individuals.
Hiroshi Ujike, Yukitaka Morita
doaj   +1 more source

Signal transduction of the CB1 cannabinoid receptor [PDF]

Journal of Molecular Endocrinology, 2009
The CB1 cannabinoid receptor (CB1R) is the major cannabinoid receptor in neuronal cells and the brain, but it also occurs in endocrine cells and other peripheral tissues. CB1R is a member of the superfamily of G-protein-coupled receptors (GPCRs), which are characterized by seven transmembrane helices.
Gábor, Turu, László, Hunyady
openaire   +2 more sources

Obesity and the endocannabinoid system: Is there still a future for CB1 antagonists in obesity? [PDF]

, 2013
The current epidemic of obesity in western countries is being worsened by the lack of effective pharmacotherapies. The apparent success of a central nervous systemacting cannabinoid CB1 receptor antagonist-based treatment for obesity was hampered by the ...
Baixeras, Elena, Goya, Pilar, Pavon, Francisco Javier, Rodríguez de Fonseca, Fernando, Romero-Cuevas, Miguel, Serrano, Antonia, Suarez, Juan   +6 more
core   +2 more sources

Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes

Frontiers in Pharmacology, 2018
Cannabigerol (CBG) is one of the major phytocannabinoids present in Cannabis sativa L. that is attracting pharmacological interest because it is non-psychotropic and is abundant in some industrial hemp varieties.
Gemma Navarro, K. Varani, Irene Reyes-Resina, Verónica Sánchez de Medina, Rafael Rivas-Santisteban, C. Sánchez-Carnerero Callado, F. Vincenzi, S. Casano, C. Ferreiro-Vera, E. Canela, P. Borea, X. Nadal, R. Franco   +12 more
semanticscholar   +1 more source

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s) [PDF]

, 2015
ACKNOWLEDGMENTS The work was supported by National Institutes of Health grants DA027113 and EY024717 to G.A.T. and DA09158 to A.M. A portion of this work was submitted in 2011 by A. Kulkarni in partial fulfillment of M.S.
Cascio, Maria G., Denovan-Wright, Eileen M., Janero, David R., Korde, Anisha, Kulkarni, Abhijit R., Kulkarni, Pushkar M., Laprairie, Robert B., Makriyannis, Alexandros, Pertwee, Roger G., Thakur, Ganesh A., Tichkule, Ritesh B., Zhou, Han, Zvonok, Nikolai   +12 more
core   +3 more sources

Differential expression of brain cannabinoid receptors between repeatedly stressed males and females may play a role in age and gender-related difference in traumatic brain injury: Implications from animal studies

Frontiers in Neurology, 2014
Inconsistent gender differences in the outcome of TBI have been reported. The mechanism is unknown. In a recent male animal study, repeated stress followed by TBI had synergistic effects on brain gene expression and caused greater behavioral deficits ...
Guoqiang eXing, Guoqiang eXing, Janis eCarlton, Xiaolong eJiang, Jillian eWen, Jillian eWen, Min eJia, He eLi   +7 more
doaj   +1 more source

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. [PDF]

PLoS ONE, 2008
Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation.
Blerina Kola, Imre Farkas, Mirjam Christ-Crain, Gábor Wittmann, Francesca Lolli, Faisal Amin, Judith Harvey-White, Zsolt Liposits, George Kunos, Ashley B Grossman, Csaba Fekete, Márta Korbonits   +11 more
doaj   +1 more source

The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons

PLoS Biology, 2015
The molecular composition of the cannabinoid type 1 (CB1) receptor complex beyond the classical G-protein signaling components is not known. Using proteomics on mouse cortex in vivo, we pulled down proteins interacting with CB1 in neurons and show that ...
C. Njoo, N. Agarwal, B. Lutz, R. Kuner
semanticscholar   +1 more source