Results 61 to 70 of about 22,652 (233)

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections [PDF]

, 2012
Background: After focal neuronal injury the endocannabinioid system becomes activated and protects or harms neurons depending on cannabinoid derivates and receptor subtypes.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Natsuo Ueda, Ueda Natsuo, Dehghani Faramarz, Faramarz Dehghani (109822), Hobusch Constance, Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Koch Marco, Geisslinger Gerd, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Natsuo Ueda (176896), Constance Hobusch, Kallendrusch Sonja, Ehrlich Angela, Kallendrusch, Sonja, Ueda, Natsuo, Marco Koch, Angela Ehrlich (109799)   +31 more
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CB1 Cannabinoid Receptor Stimulation Modulates Transient Receptor Potential Vanilloid Receptor 1 Activities in Calcium Influx and Substance P Release in Cultured Rat Dorsal Root Ganglion Cells

Journal of Pharmacological Sciences, 2005
Cannabinoids have been reported to have analgesic properties in animals of acute nociception or of inflammatory and neuropathic pain models, but the mechanisms by which they exert such alleviative effects are not yet fully understood.
Kyoko Oshita, Atsuko Inoue, He-Bin Tang, Yoshihiro Nakata, Masashi Kawamoto, Osafumi Yuge   +5 more
doaj   +1 more source

Targeting the Endocannabinoid CB1 Receptor to Treat Body Weight Disorders: A Preclinical and Clinical Review of the Therapeutic Potential of Past and Present CB1 Drugs

Biomolecules, 2020
Obesity rates are increasing worldwide and there is a need for novel therapeutic treatment options. The endocannabinoid system has been linked to homeostatic processes, including metabolism, food intake, and the regulation of body weight.
Thomas Murphy, Bernard Le Foll
doaj   +1 more source

Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]

PLoS ONE, 2014
Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow, Kelly Jiang, Alipi V Naydenov, Joshua H Le, Nephi Stella, Neil M Nathanson   +5 more
doaj   +1 more source

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

The F238L Point Mutation in the Cannabinoid Type 1 Receptor Enhances Basal Endocytosis via Lipid Rafts

Frontiers in Molecular Neuroscience, 2018
Defining functional domains and amino acid residues in G protein coupled receptors (GPCRs) represent an important way to improve rational drug design for this major class of drug targets.
Melanie Wickert, Keri L. Hildick, Gemma L. Baillie, Ruth Jelinek, Alejandro Aparisi Rey, Krisztina Monory, Miriam Schneider, Miriam Schneider, Ruth A. Ross, Jeremy M. Henley, Beat Lutz, Beat Lutz   +11 more
doaj   +1 more source

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

British Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr, Christiane Dings, Omar Zaher, Frederike Nordmeier, Nadja Walle, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer, Thorsten Lehr, Nadine Schaefer   +10 more
wiley   +1 more source

Sex‐dependent pharmacological profiles of the synthetic cannabinoid MMB‐Fubinaca

, 2021
Synthetic cannabinoids have emerged as novel psychoactive substances with damaging consequences for public health. They exhibit high affinity at the cannabinoid type-1 (CB1) receptor and produce similar and often more potent effects as other CB1 receptor
MARSICANO, Giovanni, BUSQUETS-GARCIA, Arnau, Antonio C. Pagano Zottola, Monica Fernandez, Arnau Busquets‐Garcia, OLIVEIRA DA CRUZ, Jose F., MUGURUZA, Carolina, GOMEZ-SOTRES, Paula, FERNANDEZ, Monica, Giovanni Marsicano, José F. Oliveira da Cruz, Carolina Muguruza, IOANNIDOU, Christina, Luis F. Callado, Christina Ioannidou, Paula Gomez‐Sotres, CALLADO, Luis F., PAGANO ZOTTOLA, Antonio C.   +17 more
core   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

A lesão dopaminérgica como modelo de estágio pré-motor da doença de Parkinson: efeitos do antagonismo do receptor CB1 [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010Além dos sinais motores clássicos, a doença de Parkinson é caracterizada por déficits cognitivos e ...
Tadaiesky, Meigy Tavares
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