Results 81 to 90 of about 22,652 (233)

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis

, 2007
Endocannabinoids are lipid signaling mediators that exert an important neuromodulatory role and confer neuroprotection in several types of brain injury.
Monory, Krisztina, Sendtner, Michael, Romero, Eva, Lutz, Beat, Guzmán Pastor, Manuel, Marsicano, Giovanni, Galve Roperh, Ismael, Aguado Sánchez, Tania, Palazuelos Diego, Javier   +8 more
core   +1 more source

Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia

Frontiers in Veterinary Science, 2019
Growing evidence indicates cannabinoid receptors as potential therapeutic targets for chronic pain. Consequently, there is an increasing interest in developing cannabinoid receptor agonists for treating human and veterinary pain. To better understand the
Roberto Chiocchetti, Giorgia Galiazzo, Claudio Tagliavia, Agnese Stanzani, Fiorella Giancola, Marika Menchetti, Gianfranco Militerno, Chiara Bernardini, Monica Forni, Luciana Mandrioli   +9 more
doaj   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, EarlyView.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Interação entre os sistemas endocanabinóide e glicocorticóide na extinção do condicionamento aversivo contextual em ratos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA regulação das respostas emocionais é essencial para a saúde mental e a forma mais simples de regulação destas respostas é
Bitencourt, Rafael Mariano de
core  

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer ...
Klaudia Barabas, Yanagawa, Yuchio, Harkany, Tibor, Giuseppe Tortoriello, Masaaki Torii, Cameron, Gary, Yuchio Yanagawa, Tortoriello, Giuseppe, Gary Cameron, Morozov, Yury M, Watanabe, Masahiko, Masahiko Watanabe, Barabas, Klaudia, Erik Keimpema, Ken Mackie, Keimpema, Erik, Tibor Harkany, Yury M. Morozov, Torii, Masaaki, Mackie, Ken   +19 more
core   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Efeito do canabidiol sobre a reconsolidação da memória de medo ao contexto: envolvimento dos receptores CB1 do córtex pré-límbico [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.A busca por drogas que prejudicam a reconsolidação de memórias traumáticas pode ter um impacto ...
Stern, Cristina Aparecida Jark
core  

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Lipoxina A4: um modulador alostérico endocanabinóide no sistema nervoso central [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciênicas Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010Lipoxinas e endocanabinóides são eicosanóides endógenos que são liberados sob demanda em resposta à ...
Pamplona, Fabrício Alano
core  

Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor

Biomolecules, 2020
Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress and genetic factors acting through immunological and endocrine responses generate structural and functional ...
Graziela Vieira, Juliana Cavalli, Elaine C. D. Gonçalves, Saulo F. P. Braga, Rafaela S. Ferreira, Adair R. S. Santos, Maíra Cola, Nádia R. B. Raposo, Raffaele Capasso, Rafael C. Dutra   +9 more
doaj   +1 more source