Results 101 to 110 of about 59,314 (277)

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cannabinoid Hyperemesis Syndrome [PDF]

, 2015
Legalization of marijuana use will increase the number of people who will become long-term users. A prior medical record review study in Australia, in 2004, identified 19 chronic marijuana users who entered the emergency department with recurrent ...
Heise, Lynn
core   +2 more sources

Internalization and Recycling of the CB1 Cannabinoid Receptor [PDF]

Journal of Neurochemistry, 1999
Abstract : Tolerance develops rapidly to cannabis, cannabinoids, and related drugs acting at the CB1 cannabinoid receptor. However, little is known about what happens to the receptor as tolerance is developing. In this study, we have found that CB1 receptors are rapidly internalized following agonist binding and receptor activation ...
C, Hsieh, S, Brown, C, Derleth, K, Mackie   +3 more
openaire   +2 more sources

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice [PDF]

, 2019
Background With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects.
Boehm, Stephen L., II, Lapish, Christopher C., Mackie, Ken, Smoker, Michael P.   +3 more
core   +2 more sources

Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia

Frontiers in Veterinary Science, 2019
Growing evidence indicates cannabinoid receptors as potential therapeutic targets for chronic pain. Consequently, there is an increasing interest in developing cannabinoid receptor agonists for treating human and veterinary pain. To better understand the
Roberto Chiocchetti, Giorgia Galiazzo, Claudio Tagliavia, Agnese Stanzani, Fiorella Giancola, Marika Menchetti, Gianfranco Militerno, Chiara Bernardini, Monica Forni, Luciana Mandrioli   +9 more
doaj   +1 more source

A collection of cannabinoid-related negative findings from autaptic hippocampal neurons

Scientific Reports, 2023
Autaptic hippocampal neurons are an architecturally simple model of neurotransmission that express several forms of cannabinoid signaling. Over the past twenty years this model has proven valuable for studies ranging from enzymatic control of ...
Alex Straiker, Michaela Dvorakova, Taryn Bosquez-Berger, Jaroslav Blahos, Ken Mackie   +4 more
doaj   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Endocannabinoid-related compounds in gastrointestinal diseases [PDF]

, 2018
The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro, Esposito, Giuseppe, Gigli, Stefano, Giovanni, Sarnelli, Marcella, Pesce, Osvaldo, Borrelli, Rosario, Cuomo, Seguella, Luisa   +7 more
core   +1 more source