Results 121 to 130 of about 59,314 (277)
British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
wiley +1 more source
Endogenous Dopamine and Endocannabinoid Signaling Mediate Cocaine-Induced Reversal of AMPAR Synaptic Potentiation in the Nucleus Accumbens Shell [PDF]
, 2018 Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior.
Hearing, Matthew +3 more
core +2 more sources
PhotonicsBackground: The interaction between the endocannabinoid system (ECS), specifically the CB1 and CB2 cannabinoid receptors, and neuropathy has aroused great research interest due to the possible implications for treatment.
Danielle Paula Freitas Bataus Silva +3 more
doaj +1 more source
Journal of Biological Chemistry, 2012 Background: G protein-coupled receptors (GPCR) can form heteromers and thereby alter their signaling properties. Results: GPR55 and cannabinoid 1 (CB1) receptor signaling is modulated if receptors are co-expressed.
J. Kargl +5 more
semanticscholar +1 more source
UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Migraine
Brain and Behavior, Volume 16, Issue 4, April 2026.This case series followed patients receiving medicinal cannabis for migraine headache for up to 2 years. At 24 months, there were significant improvements in measures assessing headache impact, anxiety, sleep quality, and general quality of life. Note that 15.27% of patients reported an adverse event, most of which were mild or moderate in severity ...
Lennon Hooper +8 more
wiley +1 more source
Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol
Arhiv za Higijenu Rada i Toksikologiju, 2020 Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. The effects of cannabinoids therefore differ not just because
Černe Katarina
doaj +1 more source
Trick or Treat: Unintentional Cannabis Intoxication From Edibles in a Preschool Child—A Case Report
Clinical Case Reports, Volume 14, Issue 4, April 2026.Case report on a 5‐year‐old female patient presenting with various organic symptoms after consumption of tetrahydrocannabinol (THC)‐containing gummy bears. Icons provided by Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/).
Eileen Heiler +4 more
wiley +1 more source
Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse [PDF]
, 2019 In the isolated rat carotid artery, the endocannabinoid anandamide induces endothelium-dependent relaxation via activation of the enzyme sphingosine kinase (SK).
Alganga, Husam +10 more
core +2 more sources
Journal of Neuroscience, 1997 Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. Within the striatum, CB1 receptors have been shown to be localized on the same neurons as Gi-coupled dopamine D2 receptors.
M. Glass, C. Felder
semanticscholar +1 more source
The Neuroprotective Effect of Cannabinoid Receptor Agonist (WIN55,212-2) in Paraoxon Induced Neurotoxicity in PC12 Cells and N-methyl-D-aspartate Receptor Interaction [PDF]
Cell Journal, 2010 Objective: Considering that cannabinoids protect neurons against neurodegeneration, inthis study, the neuroprotective effect of WIN55,212-2 in paraoxon induced neurotoxicity inPC12 cells and the role of the N-methyl-D-aspartate (NMDA) receptor were ...
Hedayat Sahraei +4 more
doaj