Results 131 to 140 of about 59,314 (277)

Fatty acid metabolism—an emerging regulatory node in T‐cell immunometabolism

Clinical &Translational Immunology, Volume 15, Issue 4, 2026.
Abstract While the roles of glucose metabolism and tricarboxylic acid (TCA) cycle intermediates in immune regulation are well established, the contribution of fatty acid metabolism remains less well defined. In this review, we examine current knowledge on the immunomodulatory functions of fatty acid metabolism, with a particular focus on T‐cell biology.
Brett Chapel Arenberg, Michael N Sack, Jing Wu   +2 more
wiley   +1 more source

CB1 Cannabinoid Receptor Activation Dose-Dependently Modulates Neuronal Activity within Caudal but not Rostral Song Control Regions of Adult Zebra Finch Telencephalon [PDF]

, 2008
CB1 cannabinoid receptors are distinctly expressed at high density within several regions of zebra finch telencephalon including those known to be involved in song learning (lMAN and Area X) and production (HVC and RA).
A Reiner, A Reiner, AJ Doupe, AP Reiner, C Scharff, CJ Fowler, F Chaperon, F Nottebohm, IS McGregor, JJ Bolhuis, K Mackie, K Mackie, K Soderstrom, K Soderstrom, K Soderstrom, K Soderstrom, K Soderstrom, K Soderstrom, K Soderstrom, Ken Soderstrom, L Spear, MR Elphick, NA Patel, O Whitney, P Mailleux, Qiyu Tian, RG Pertwee, RG Pertwee, RI Wilson, RS Peterson, S Patel, SW Bottjer, SW Bottjer, TW Troyer   +33 more
core   +1 more source

New Insights into Cannabis Consumption; Abuses and Possible Therapeutic Effects [PDF]

, 2015
Cannabis is one of the oldest psychotropic drugs known to humanity. The paper assesses the current knowledge on the cannabis, including the mechanisms of action and the therapeutic potential of cannabinoids.
Baconi, Daniela Luiza, Bălălău, Cristian, Vasile, Robert Daniel   +2 more
core   +3 more sources

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Bisogno, Chiang, Cravatt, Cravatt, De Marchi, Despres, Devane, Di, Di Marzo, Di Marzo, Fernandez, Freund, Giuffrida, Giuffrida, Habayeb, Klein, Klein, Maccarrone, Matsuda, Munro, Obata, Parolaro, Pertwee, Randall, Sipe, Sparling, Sugiura, Wagner, Wagner, Walker, Yamaji   +30 more
core   +1 more source

New Insights in Cannabinoid Receptor Structure and Signaling.

Current Molecular Pharmacology, 2019
BACKGROUND Cannabinoid has long been used for medicinal purposes. Cannabinoid signaling has been considered the therapeutic targets for treating pain, addiction, obesity, inflammation, and other diseases. Recent studies have suggested that in addition to
Li-Ya Ye, Zheng Cao, Weiwei Wang, N. Zhou   +3 more
semanticscholar   +1 more source

Correspondence between morphological similarity of the left lateral orbitofrontal cortex and neurotransmitter systems in adolescent males with autism

General Psychiatry, Volume 39, Issue 2, April 2026.
ABSTRACT Background Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by pronounced heterogeneity in brain structure, which limits the development of targeted interventions. Morphological brain networks (MBNs) enable the mapping of coordinated structural features across brain regions at the individual level.
Huashuang Zhang, Junle Li, Chensheng Hou, Yilin Huang, Lisha Ma, Bincan Xiong, Jinhui Wang, Xuchu Weng   +7 more
wiley   +1 more source

Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women? [PDF]

, 2009
Objective: The aim of this study was to determine whether genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity, fat distribution and obesity-related metabolic disorders in Polish postmenopausal women.Design and ...
Andrzej Milewicz, Diana Jedrzejuk, Felicja Lwow, Katarzyna Dunajska, Lukasz Laczmanski, Urszula Tworowska-Bardzinska   +5 more
core   +1 more source

CB1 Cannabinoid Receptor Location and CRIP1a

The FASEB Journal, 2011
CB 1 cannabinoid receptor (CB 1 R) is a Gi/o linked GPCR that influences psychological processes such as mood and memory. Cannabinoid Receptor Interacting Protein (CRIP1a) has been shown to interact with the C‐terminal tail of the CB
Jeremy O'Neal, Lawrence C. Blume, Caroline E. Bass, Allyn C. Howlett   +3 more
openaire   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Transmembrane Helical Domain of the Cannabinoid CB1 Receptor [PDF]

Biophysical Journal, 2009
Brain cannabinoid (CB(1)) receptors are G-protein coupled receptors and belong to the rhodopsin-like subfamily. A homology model of the inactive state of the CB(1) receptor was constructed using the x-ray structure of beta(2)-adrenergic receptor (beta(2)AR) as the template.
openaire   +2 more sources