Results 11 to 20 of about 1,263,611 (221)

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. [PDF]

PLoS ONE, 2008
Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation.
Blerina Kola, Imre Farkas, Mirjam Christ-Crain, Gábor Wittmann, Francesca Lolli, Faisal Amin, Judith Harvey-White, Zsolt Liposits, George Kunos, Ashley B Grossman, Csaba Fekete, Márta Korbonits   +11 more
doaj   +4 more sources

Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales. [PDF]

, 2007
[spa] La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden
Carriba Domínguez, Paulina
core   +6 more sources

(+)-Trans-Cannabidiol Is an Agonist at Human CB₂ Receptors. [PDF]

Pharmacol Res Perspect
ABSTRACT (−)‐trans‐Cannabidiol ((−)‐CBD) is a principal phytocannabinoid from Cannabis sativa. (−)‐CBD has complex pharmacology but is a relatively weak inhibitor of CB1 and CB2 receptor signaling. Cannabidiol has two chiral centres and thus four stereoisomers.
Burtchaell PB, Santiago MJ, Wang C, Hagdoost M, Clay EJM, Mohnot D, Connor M.   +6 more
europepmc   +2 more sources

Cannabinoids for the control of experimental multiple sclerosis [PDF]

, 2010
PhDThere have been numerous studies reporting that cannabinoids, both exogenous and endogenous, have a potential beneficial function during incidences of neurological damage.
Pryce, Gareth
core   +4 more sources

Cannabinoid CB₁ allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression. [PDF]

Br J Pharmacol
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Solomon ID, Garai S, Thakur GA, Hohmann AG.   +3 more
europepmc   +2 more sources

Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]

, 2013
CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter, Hunyady, L., Gyombolai, Pál, Boros, E., Turu, G., Turu, Gábor, Gyombolai, P., Hunyady, László   +7 more
core   +1 more source

Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice.

PLoS ONE, 2011
It is well known that acute challenges with psychostimulants such as amphetamine affect impulsive behavior. We here studied the pharmacology underlying the effects of amphetamine in two rat models of impulsivity, the 5-choice serial reaction time task (5-
Joost Wiskerke, Nicky Stoop, Dustin Schetters, Anton N M Schoffelmeer, Tommy Pattij   +4 more
doaj   +1 more source

Optimization of cAMP fluorescence dataset from ACTOne cannabinoid receptor 1 cell line

Data in Brief, 2016
The ACTOne cannabinoid receptor 1 functional system is comprised of transfected HEK cells with the parental cyclic nucleotide gated channel (CNG) co-transfected with cannabinoid receptor 1 (CB1).
Chaela S. Presley, Ammaar H. Abidi, Bob M. Moore, II   +2 more
doaj   +1 more source

Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease [PDF]

, 2014
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
Silvia Cianci, ROMANO, ADELE, Romano, A, M. r. Elphick, Gianluigi Vendemiale, Pace, Lorenzo, Elphick, Maurice R, Bedse, G, Angelo M. Lavecchia, Gaurav Bedse, GAETANI, SILVANA, VENDEMIALE, GIANLUIGI, LAVECCHIA, ANGELO MICHELE, @CORRESPONDING AUTHOR, Vendemiale, G, CIANCI, SILVIA, Pace Lorenzo, Lorenzo Federico Pace, Adele Romano, Gaetani, S, Tommaso Cassano, BEDSE, GAURAV, Lorenzo, P, Caterina Grillo, Cassano, T, Grillo, C, Laferla, Frank M, ALTIERI, Fabio, Elphick, MR, LaFerla, FM, Maurice R. Elphick, GRILLO, CATERINA, Silvana Gaetani, Frank M. LaFerla, F. m. Laferla, CASSANO, TOMMASO, Lavecchia, AM, Fabio Altieri, Altieri, F, Cianci, S   +39 more
core   +1 more source

Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

Frontiers in Pharmacology, 2019
Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and ...
Daniel García-Rincón, Daniel García-Rincón, Javier Díaz-Alonso, Javier Díaz-Alonso, Juan Paraíso-Luna, Juan Paraíso-Luna, Zaira Ortega, Zaira Ortega, José Aguareles, José Aguareles, Adán de Salas-Quiroga, Adán de Salas-Quiroga, Cristina Jou, Inmaculada de Prada, Verónica Martínez-Cerdeño, Eleonora Aronica, Eleonora Aronica, Manuel Guzmán, Manuel Guzmán, María Ángeles Pérez-Jiménez, Ismael Galve-Roperh, Ismael Galve-Roperh   +21 more
doaj   +1 more source