Results 11 to 20 of about 43,721 (231)

Signal transduction of the CB1 cannabinoid receptor [PDF]

Journal of Molecular Endocrinology, 2009
The CB1 cannabinoid receptor (CB1R) is the major cannabinoid receptor in neuronal cells and the brain, but it also occurs in endocrine cells and other peripheral tissues. CB1R is a member of the superfamily of G-protein-coupled receptors (GPCRs), which are characterized by seven transmembrane helices.
Gábor, Turu, László, Hunyady
openaire   +2 more sources

Cannabinoids facilitate the swallowing reflex elicited by the superior laryngeal nerve stimulation in rats. [PDF]

PLoS ONE, 2012
Cannabinoids have been reported to be involved in affecting various biological functions through binding with cannabinoid receptors type 1 (CB1) and 2 (CB2).
Rahman Md Mostafeezur, Hossain Md Zakir, Hanako Takatsuji, Yoshiaki Yamada, Kensuke Yamamura, Junichi Kitagawa   +5 more
doaj   +1 more source

Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function*

Journal of Biological Chemistry, 2006
Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A.
James Ellis, J. Pediani, Meritxell Canals, S. Milasta, G. Milligan   +4 more
semanticscholar   +1 more source

Optimization of cAMP fluorescence dataset from ACTOne cannabinoid receptor 1 cell line

Data in Brief, 2016
The ACTOne cannabinoid receptor 1 functional system is comprised of transfected HEK cells with the parental cyclic nucleotide gated channel (CNG) co-transfected with cannabinoid receptor 1 (CB1).
Chaela S. Presley, Ammaar H. Abidi, Bob M. Moore, II   +2 more
doaj   +1 more source

Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

Frontiers in Pharmacology, 2019
Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and ...
Daniel García-Rincón, Daniel García-Rincón, Javier Díaz-Alonso, Javier Díaz-Alonso, Juan Paraíso-Luna, Juan Paraíso-Luna, Zaira Ortega, Zaira Ortega, José Aguareles, José Aguareles, Adán de Salas-Quiroga, Adán de Salas-Quiroga, Cristina Jou, Inmaculada de Prada, Verónica Martínez-Cerdeño, Eleonora Aronica, Eleonora Aronica, Manuel Guzmán, Manuel Guzmán, María Ángeles Pérez-Jiménez, Ismael Galve-Roperh, Ismael Galve-Roperh   +21 more
doaj   +1 more source

Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors.

Pharmacological Research, 2020
BACKGROUND Recent approved medicines whose active principles are Δ9Tetrahidrocannabinol (Δ9-THC) and/or cannabidiol (CBD) open novel perspectives for other phytocannabinoids also present in Cannabis sativa L. varieties.
Gemma Navarro, K. Varani, Alejandro Lillo, F. Vincenzi, Rafael Rivas-Santisteban, Iu Raïch, Irene Reyes-Resina, C. Ferreiro-Vera, P. Borea, Verónica Sánchez de Medina, X. Nadal, R. Franco   +11 more
semanticscholar   +1 more source

Cannabinoid CB1 receptor [PDF]

Science-Business eXchange, 2008
  +12 more sources

The dynamic nature of type 1 cannabinoid receptor (CB1) gene transcription

British Journal of Pharmacology, 2012
R. Laprairie, M. Kelly, E. Denovan‐Wright   +2 more
exaly   +2 more sources

AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity. [PDF]

PLoS ONE, 2010
The CB1 cannabinoid receptor is the most abundant G-protein coupled receptor in the brain and a key regulator of neuronal excitability. There is strong evidence that CB1 receptor on glutamatergic hippocampal neurons is beneficial to alleviate ...
Stephan Guggenhuber, Krisztina Monory, Beat Lutz, Matthias Klugmann   +3 more
doaj   +1 more source

Cannabinoid CB1 and CB2 Receptor Signaling and Bias

Cannabis and Cannabinoid Research, 2017
An agonist that acts through a single receptor can activate numerous signaling pathways. Recent studies have suggested that different ligands can differentially activate these pathways by stabilizing a limited range of receptor conformations, which in ...
Mikkel Søes Ibsen, M. Connor, M. Glass
semanticscholar   +1 more source