Results 251 to 260 of about 247,999 (295)

CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a

Molecular Pharmacology, 2007
The CB1 cannabinoid receptor is a G-protein coupled receptor that has important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection. We report the discovery of two structurally related CB1 cannabinoid receptor interacting proteins (CRIP1a and CRIP1b) that bind to the distal C-terminal tail of CB1.
Jason L, Niehaus, Yunguang, Liu, Kathleen T, Wallis, Michaela, Egertová, Sheela G, Bhartur, Somnath, Mukhopadhyay, Shanping, Shi, Hengjun, He, Dana E, Selley, Allyn C, Howlett, Maurice R, Elphick, Deborah L, Lewis   +11 more
openaire   +2 more sources

Modulation of cannabinoid receptor signaling by endocannabinoids

2022
AbstractEndocannabinoids (eCBs) are endogenous lipid molecules that activate the cannabinoid receptor 1 (CB1), a G protein coupled receptor (GPCR) that signals primarily through the Gi/o family of G proteins to regulate neurotransmitter release. Consequently, CB1 is an important therapeutic target for several neurological disorders.
Kaavya Krishna Kumar, Michael J. Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S. Powers, Lipin Ji, Spyros P. Nikas, Maria Gerasi, Kiran Vemuri, Ron O. Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian Kobilka   +14 more
openaire   +1 more source

Modulation of transmitter release via presynaptic cannabinoid receptors

Trends in Pharmacological Sciences, 2001
Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In this article, the effects of modulation of transmitter release by cannabinoids in both the CNS and the PNS of various species, including humans, will be discussed ...
E, Schlicker, M, Kathmann
openaire   +2 more sources

Modulation of Excitatory Synaptic Transmission During Cannabinoid Receptor Activation

Cellular and Molecular Neurobiology, 2021
The present research has reported that cannabinoid receptor 1 (CB1) agonist, delta-(9)-tetrahydrocannabinol (THC) modulates synaptogenesis during overexcitation. Microtubule and synaptic distribution, poly(ADP)-ribose (PAR) accumulation were estimated during overexcitation and in the presence of THC.
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Cannabinoid CB1 receptor antagonism modulates plasma corticosterone in rodents

European Journal of Pharmacology, 2006
Although the involvement of cannabinoids and the endogenous cannabinoid system in the regulation of the hypothalamo-pituitary-adrenal axis in rodents is well documented, the precise role played by the cannabinoid type one (CB(1)) receptor in this effect has not been fully elucidated.
Mark R, Wade, Aldemar, Degroot, George G, Nomikos   +2 more
openaire   +2 more sources

D2 Dopamine Receptors Modulate Gα-Subunit Coupling of the CB1 Cannabinoid Receptor

The Journal of Pharmacology and Experimental Therapeutics, 2004
CB(1) cannabinoid (CB(1)) and D(2) dopamine (D(2)) receptors are known to couple to the G protein Galpha(i/o). It has been reported that concurrent activation of D(2) receptors and CB(1) receptors, in primary striatal neuronal culture, promotes functional CB(1) receptor coupling to Galpha(s) resulting in elevations in intracellular cyclic AMP levels ...
A, Jarrahian, V J, Watts, E L, Barker
openaire   +2 more sources

Modulation of rat brain opioid receptors by cannabinoids.

The Journal of Pharmacology and Experimental Therapeutics, 1987
The interaction of delta 9-tetrahydrocannabinol (delta 9-THC) and related cannabinoids with opioid receptors of neuronal membranes has been investigated. Treatment of membranes with delta 9-THC consistently decreased specific in vitro binding of [3H]dihydromorphine (mu opioid) in a dose-dependent fashion. Similar dose-dependent changes were elicited by
P J, Vaysse, E L, Gardner, R S, Zukin
openaire   +2 more sources

Modulation of rat brain cannabinoid receptors after chronic morphine treatment

NeuroReport, 1997
Intraperitoneal injection of delta9-THC (7.5 mg/kg) in rats made tolerant to morphine by s.c. implantation of morphine pellets had a much greater analgesic effect than in placebo pellet plus delta9-THC treatment. To investigate whether this was due to some change in cannabinoid receptor levels and/or expression induced by chronic morphine, we designed ...
RUBINO, TIZIANA, Tizzoni L, VIGANO', DANIELA GIULIA, Massi P, PAROLARO, DANIELA   +4 more
openaire   +3 more sources

Cannabinoid Receptor Modulation of Synapses Received by Cerebellar Purkinje Cells

Journal of Neurophysiology, 2000
The high density of cannabinoid receptors in the cerebellum and the degradation of motor coordination produced by cannabinoid intoxication suggest that synaptic transmission in the cerebellum may be strongly regulated by cannabinoid receptors. Therefore the effects of exogenous cannabinoids on synapses received by Purkinje cells were investigated in ...
K A, Takahashi, D J, Linden
openaire   +2 more sources

Modulation of Glycine Receptor Function by the Synthetic Cannabinoid HU210

Pharmacology, 2009
Loss of inhibitory synaptic transmission within the dorsal horn of the spinal cord plays a key role in the development of chronic pain following inflammation or nerve injury. Inhibitory postsynaptic transmission in the adult spinal cord involves mainly glycine. HU210 is a non-psychotropic, synthetic cannabinoid.
Reyhan, Demir, Martin, Leuwer, Jeanne, de la Roche, Klaus, Krampfl, Nilufar, Foadi, Matthias, Karst, Reinhard, Dengler, Gertrud, Haeseler, Jörg, Ahrens   +8 more
openaire   +2 more sources