Results 1 to 10 of about 46,548 (264)

Network Pharmacology, Molecular Docking and Molecular Dynamics to Explore the Potential Immunomodulatory Mechanisms of Deer Antler

International Journal of Molecular Sciences, 2023
The use of deer antlers dates back thousands of years in Chinese history. Deer antlers have antitumor, anti-inflammatory, and immunomodulatory properties and can be used in treating neurological diseases.
Wei Hu, Yang Mei, Hu Wei
exaly   +2 more sources

Molecular Pharmacology in Diabetes

International Journal of Molecular Sciences
This Special Issue highlights the key molecules and molecular signaling pathways associated with diabetes and its multifaceted complications [...
Rosa Fernandes, Flávio Reis
core   +3 more sources

Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster

Cells, 2022
The dopamine transporter (DAT) is a member of the neurotransmitter:sodium symporter (NSS) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission.
Ciara Frances Pugh, Brian Thomas DeVree, Solveig Gaarde Schmidt, Claus Juul Loland   +3 more
doaj   +1 more source

Systematic analysis of molecular biological mechanisms for supporting connective tissue metabolism with chondroitin sulfate

Неврология, нейропсихиатрия, психосоматика, 2021
Objective: to analyze the roles of undifferentiated connective tissue dysplasia (UCTD) in the development of cartilage and ligamentous apparatus diseases.Material and methods. This paper presents the results of analyzing the literature on fundamental and
I. Yu. Torshin, O. A. Gromova, G. I. Nechaeva, I. A. Reier, N. V. Zagorodniy   +4 more
doaj   +1 more source

Decoding the mechanisms of allostery

eLife, 2023
A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.
Saif Khan, Cornelius Gati
doaj   +1 more source

Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomolecules

Frontiers in Pharmacology, 2022
Cannabis sativa contains more than 120 cannabinoids and 400 terpene compounds (i.e., phytomolecules) present in varying amounts. Cannabis is increasingly available for legal medicinal and non-medicinal use globally, and with increased access comes the ...
Ayat Zagzoog, Ashley Cabecinha, Hanan Abramovici, Robert B. Laprairie, Robert B. Laprairie   +4 more
doaj   +1 more source

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Frontiers in Pharmacology, 2022
Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders.
Asher L. Brandt, Sumanta Garai, Ayat Zagzoog, Dow P. Hurst, Lesley A. Stevenson, Roger G. Pertwee, Gregory H. Imler, Patricia H. Reggio, Ganesh A. Thakur, Robert B. Laprairie, Robert B. Laprairie   +10 more
doaj   +1 more source

Transcriptional Activation, Deactivation and Rebound Patterns in Cortex, Hippocampus and Amygdala in Response to Ketamine Infusion in Rats

Frontiers in Molecular Neuroscience, 2022
Ketamine, an N-methyl-D-aspartate (NMDA)-receptor antagonist, is a recently revitalized treatment for pain and depression, yet its actions at the molecular level remain incompletely defined.
Jenny J. Kim, Matthew R. Sapio, Fernando A. Vazquez, Dragan Maric, Amelia J. Loydpierson, Wenting Ma, Carlos A. Zarate, Michael J. Iadarola, Andrew J. Mannes   +8 more
doaj   +1 more source

Molecular pharmacology of GPCRs [PDF]

British Journal of Pharmacology, 2018
Linked ArticlesThis article is part of a themed section on Molecular Pharmacology of GPCRs. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.21 ...
Christopher J, Langmead, Roger J, Summers   +1 more
openaire   +2 more sources

Chemotranscriptomic analysis of 7-hydroxymatairesinol-related effects on MCF7 human breast tumor cells

Акушерство, гинекология и репродукция, 2023
Introduction. Establishing the effects of anticancer drugs on the transcriptome is an important procedure in postgenomic pharmacology necessary to comprehensively assess the desired and undesirable effects of candidate drugs.
I. Yu. Torshin, A. N. Rubashkina, O. A. Gromova   +2 more
doaj   +1 more source