Results 31 to 40 of about 46,548 (264)
Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation
iScience, 2023 Summary: Pulmonary fibrosis (PF) is a fatal and irreversible respiratory disease accompanied by excessive fibroblast activation. Previous studies have suggested that cAMP signaling pathway and cGMP-PKG signaling pathway are continuously down-regulated in
Ya-Jun Li +8 more
doaj +1 more source
iScience, 2023 Summary: Overdose acetaminophen (APAP) can cause acute liver injury (ALI), but the underlying mechanism remains undetermined. This study explored the role of hepatic Zinc Finger And BTB Domain Containing 22 (ZBTB22) in defense against APAP-mediated ...
Yingjian Chen +13 more
doaj +1 more source
, 2022 Heart failure (HF) is a clinical syndrome of cardiac insufficiency caused by abnormalities in cardiac structure and function that arise for various reasons, and it is the final stage of most cardiovascular diseases’ progression.
Sun, Shuchan +25 more
core +1 more source
Neurotrophic and antioxidant potential of neuropeptides and trace elements
Неврология, нейропсихиатрия, психосоматика, 2016 Neurotrophic therapy with brain extract-based drugs has been performed for decades. The basis for their neurotrophic activity is amino acids and neuropeptides.
O. A. Gromova +4 more
doaj +1 more source
, 2012 The history of pharmacology travels together to history of scientific method and the latest frontiers of pharmacology open a new world in the search of drugs.
core +1 more source
Dysregulation of angiotensin converting enzyme 2 expression and function in comorbid disease conditions possibly contributes to coronavirus infectious disease 2019 complication severity [PDF]
, 2021 ACE2 has emerged as a double agent in the COVID-19 ordeal, as it is both physiologically protective and virally conducive. The identification of ACE2 in as many as 72 tissues suggests that extrapulmonary invasion and damage is likely, which indeed has ...
Abdelhady, Samar +7 more
core +1 more source
Clinical and Molecular Pharmacology of Etomidate [PDF]
Anesthesiology, 2011 This review focuses on the unique clinical and molecular pharmacologic features of etomidate. Among general anesthesia induction drugs, etomidate is the only imidazole, and it has the most favorable therapeutic index for single-bolus administration. It also produces a unique toxicity among anesthetic drugs: inhibition of adrenal steroid synthesis that ...
Stuart A. Forman, David S. Warner
openaire +2 more sources
High-resolution view of compound promiscuity [v2; ref status: indexed, http://f1000r.es/1ig]
F1000Research, 2013 Compound promiscuity is defined as the ability of a small molecule to specifically interact with multiple biological targets. So-defined promiscuity is relevant for drug discovery because it provides the molecular basis of polypharmacology, which is ...
Ye Hu, Jürgen Bajorath
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source