Results 21 to 30 of about 46,548 (264)

An integrated approach of network pharmacology and molecular docking analyses for identification of Lepidium sativum L. antidiabetic molecular targets [PDF]

Records of Pharmaceutical & Biomedical Sciences, 2023
Lepidium sativum L. is one of the most important medicinal plants with many reported pharmacological activities. One of these activities is the antidiabetic activity which is not extensively studied.
Alaa El-Banna
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On the role of glycogen synthase kinases in the molecular mechanisms of stress conditions and prospects for the use of lithium ascorbate

Неврология, нейропсихиатрия, психосоматика, 2022
It is well known that a complex of nervous and hormonal signals during stress stimulates adrenal glands to secrete adrenaline, norepinephrine and cortisol.
I. Yu. Torshin, O. A. Gromova, O. A. Limanova   +2 more
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A Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Pharmacological Mechanism of Astragalus membranaceus for Glioma

, 2023
Glioma treatment in traditional Chinese medicine has a lengthy history. Astragalus membranaceus, a traditional Chinese herb that is frequently utilized in therapeutic practice, is a component of many Traditional Chinese Medicine formulas that have been ...
Dong Wu, Peng Zhu, Wenbin Deng, Yu Feng
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Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Frontiers in Molecular Neuroscience, 2019
In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with the ...
Robert B. Laprairie, Robert B. Laprairie, Kawthar A. Mohamed, Ayat Zagzoog, Melanie E. M. Kelly, Melanie E. M. Kelly, Lesley A. Stevenson, Roger Pertwee, Eileen M. Denovan-Wright, Ganesh A. Thakur   +9 more
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Chemotranscriptome analysis of the ethylmethylhydroxypyridine succinate molecule in the context of postgenomic pharmacology

Неврология, нейропсихиатрия, психосоматика, 2020
Postgenomic pharmacology deals with the desirable and undesirable effects of drugs in relation to the genome, transcriptome, proteome, and reactome.
O. A. Gromova, I. Yu. Torshin, A. I. Sorokin, V. A. Semenov, L. V. Stakhovskaya   +4 more
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Molecular Mechanism of the Asarum–Angelica Drug Pair in the Treatment of Periodontitis Based on Network Pharmacology and Experimental Verification

, 2023
(1) To examine the potential mechanism of the Asarum–Angelica drug pair against periodontitis and provide an experimental basis for the treatment of periodontitis with herbal medicine.
Lina Wang, Chun Shi, Meichen Tong, Ming Dong, Shuo Liu, Yuhan Wang, Qianyang Chen, Haibo Sun   +7 more
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The first 50 years of molecular pharmacology [PDF]

, 2015
In this Perspective, former and current editors of Molecular Pharmacology, together with the guest editors for this 50th Anniversary Issue, provide a historical overview of the journal since its founding in 1965.
Brown, Joan Heller, Insel, Paul A, Cull-Candy, S.G., Traynelis, S.F., Catterall, William A, Conn, P Jeffrey, Milligan, Graeme, Insel, P.A., Conn, P.J., Harden, T.K., Dingledine, Ray, Harden, T Kendall, Traynelis, Stephen F, Dingledine, R., Cull-Candy, Stuart G, Brown, J.H., Milligan, G., Catterall, W.A.   +17 more
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The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

Journal of Hematology & Oncology, 2016
Background Neuroblastoma is a relatively common and highly belligerent childhood tumor with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2-pyridylketone thiosemicarbazone series, namely di-2-pyridylketone 4,4 ...
Zhu-Ling Guo, Des R. Richardson, Danuta S. Kalinowski, Zaklina Kovacevic, Kian Cheng Tan-Un, Godfrey Chi-Fung Chan   +5 more
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Anti-Inflammatory and Antioxidant Activities of Lipophilic Fraction from Liriope platyphylla Seeds Using Network Pharmacology, Molecular Docking, and In Vitro Experiments

, 2023
Antioxidant and anti-inflammatory mechanisms counteract the pathogenesis of chronic diseases, such as diabetes, aging, and cancer. Therefore, enhancing antioxidant and anti-inflammatory functions may help manage these pathological conditions.
Van-Long Truong, Razanamanana H. G. Rarison, Yeon-Ji Bae, So-Yoon Park, Ji-Hong Bang, Woo-Sik Jeong   +5 more
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A Comparative Study of Systems Pharmacology and Gene Chip Technology for Predicting Targets of a Traditional Chinese Medicine Formula in Primary Liver Cancer Treatment

Frontiers in Pharmacology, 2022
Background: The systems pharmacology approach is a target prediction model for traditional Chinese medicine and has been used increasingly in recent years. However, the accuracy of this model to other prediction models is yet to be established.Objective:
Songzhe Li, Yang Sun, Yue Sun
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