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Nature Precedings, 2008 The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008.
Ravi Iyengar
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Advancing pharmacometrics and systems pharmacology. [PDF]
Clinical Pharmacology & Therapeutics, 2012 Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition of the importance of pharmacometrics and systems pharmacology to the discipline of clinical ...
Terzic, Andre, Waldman, Scott A.
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Frontiers in Pharmacology, 2022 Background: The systems pharmacology approach is a target prediction model for traditional Chinese medicine and has been used increasingly in recent years. However, the accuracy of this model to other prediction models is yet to be established.Objective:
Songzhe Li, Yang Sun, Yue Sun
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Frontiers in Physiology, 2021 Mathematical biology and pharmacology models have a long and rich history in the fields of medicine and physiology, impacting our understanding of disease mechanisms and the development of novel therapeutics.
Karim Azer +12 more
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Systems pharmacology of complex diseases [PDF]
Annals of the New York Academy of Sciences, 2011 Systems pharmacology approaches can be used to identify and predict drug‐induced adverse events. Disease‐centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.
Jens Hansen, Ravi Iyengar
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Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review
Frontiers in Pharmacology, 2020 Numerous studies have shown that berberine and its derivatives demonstrate important anti-tumor effects. However, the specific underlying mechanism remains unclear.
Chaohe Zhang +9 more
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Pharmacometrics and/or Systems Pharmacology [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2019 Piet H. van derGraaf
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Traditional Chinese Medicine Strategy for Treating Major Depressive Disorder Based on a Famous Formulation-Baweixiaoyaosan [PDF]
Anais da Academia Brasileira de Ciências, 2023 In this study, systematic pharmacological methods were used to reveal the potential pharmacological targets of baweixiaoyaosan in the treatment of major depressive disorder (MDD).
YONGWEI LIU, YAN LI, JING XIE
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Frontiers in Pharmacology, 2023 The therapeutic effects of traditional Chinese medicine (TCM) involve intricate interactions among multiple components and targets. Currently, computational approaches play a pivotal role in simulating various pharmacological processes of TCM.
Mengyue Fan +8 more
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Theoretical analysis reveals a role for RAF conformational autoinhibition in paradoxical activation
eLife, 2023 RAF kinase inhibitors can, under certain conditions, increase RAF kinase signaling. This process, which is commonly referred to as ‘paradoxical activation’ (PA), is incompletely understood. We use mathematical and computational modeling to investigate PA
Gaurav Mendiratta, Edward Stites
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