Results 21 to 30 of about 581,117 (305)

Master Regulators Connectivity Map: A Transcription Factors-Centered Approach to Drug Repositioning

Frontiers in Pharmacology, 2018
Drug discovery is a very expensive and time-consuming endeavor. Fortunately, recent omics technologies and Systems Biology approaches introduced interesting new tools to achieve this task, facilitating the repurposing of already known drugs to new ...
Marco A. De Bastiani, Marco A. De Bastiani, Bianca Pfaffenseller, Bianca Pfaffenseller, Fabio Klamt, Fabio Klamt   +5 more
doaj   +1 more source

Systems Biology and Systems Pharmacology of Thrombosis [PDF]

Mathematical Modelling of Natural Phenomena, 2014
Summary: Thrombus formation in flowing blood is a complex time- and space-dependent process of cell adhesion and fibrin gel formation controlled by huge intricate networks of biochemical reactions. This combination of complex biochemistry, non-Newtonian hydrodynamics, and transport processes makes thrombosis difficult to understand.
Panteleev, M. A., Sveshnikova, A. N., Belyaev, A. V., Nechipurenko, D. Y., Gudich, I., Obydenny, S. I., Dovlatova, N., Fox, S. C., Holmuhamedov, E. L.   +8 more
openaire   +1 more source

Systems Pharmacology and Network Analysis to Advance Pharmacogenomics and Precision Medicine Decisions in Type-2 Diabetes Therapy

Future Pharmacology, 2023
Diabetes mellitus type-2 (DMT2) molecular pathophysiology is still challenging since the disease represents a complex, multifactorial metabolic disease caused by polygenic defects and environmental factors.
Aikaterini Saiti, Alexandros Giannopoulos-Dimitriou, Ioannis Kazakos, Eleftheria Galatou, Ioannis S. Vizirianakis   +4 more
doaj   +1 more source

Systems Pharmacology Approach to Investigate the Mechanism of Kai-Xin-San in Alzheimer’s Disease

Frontiers in Pharmacology, 2020
Alzheimer's disease (AD) is a complex neurodegenerative disease characterized by cognitive dysfunction. Kai-Xin-San (KXS) is a traditional Chinese medicine (TCM) formula that has been used to treat AD patients for over a thousand years in China. However,
Yunxia Luo, Yunxia Luo, Dongli Li, Yanfang Liao, Chuipu Cai, Qihui Wu, Hanzhong Ke, Hanzhong Ke, Xinning Liu, Huilin Li, Honghai Hong, Yumin Xu, Qi Wang, Qi Wang, Jiansong Fang, Jiansong Fang, Shuhuan Fang, Shuhuan Fang   +17 more
doaj   +1 more source

Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies

Pharmaceutics, 2023
Early prediction, quantification and translation of cardiovascular hemodynamic drug effects is essential in pre-clinical drug development. In this study, a novel hemodynamic cardiovascular systems (CVS) model was developed to support these goals.
Yu Fu, Nelleke Snelder, Tingjie Guo, Piet H. van der Graaf, Johan. G. C. van Hasselt   +4 more
doaj   +1 more source

Systems pharmacology modeling: an approach to improving drug safety [PDF]

, 2014
Advances in systems biology in conjunction with the expansion in knowledge of drug effects and diseases present an unprecedented opportunity to extend traditional pharmacokinetic and pharmacodynamic modeling/analysis to conduct systems pharmacology ...
Bai, Jane
core   +1 more source

Best practices to maximize the use and reuse of quantitative and systems pharmacology models: recommendations from the United Kingdom quantitative and systems pharmacology network [PDF]

, 2018
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts.
Amy Cheung, S. Y., Chappell, Michael J., Chelliah, Vijayalakshmi, Cucurull-Sanchez, Lourdes, Derks, Gianne, Malik-Sheriff, Rahuman S., Penney, Mark, Phipps, Alex, Timmis, Jon, Tindall, Marcus J., van der Graaf, Piet H., Vicini, Paolo, Yates, James W. T.   +12 more
core   +3 more sources

Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance

eLife, 2023
Effector T cells need to form immunological synapses (IS) with recognized target cells to elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most T cell-based cancer immunotherapies. However, the dynamics of IS
Can Liu, Jiawei Zhou, Stephan Kudlacek, Timothy Qi, Tyler Dunlap, Yanguang Cao   +5 more
doaj   +1 more source

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]

, 2010
Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S, Drewke, C., Gomeza, J., Hennen, S., Janssen, N., Kebig, A., Kostenis, E., Merten, N., Milligan, G., Mohr, K., Mohr-Andra, M., Muller, A., Schmidt, J., Schroder, R., Smith, N.J., Wenzel, J., Zahn, S.   +16 more
core   +1 more source

Pharmacogenomic Analysis of Combined Therapies against Glioblastoma Based on Cell Markers from Single-Cell Sequencing

Pharmaceuticals, 2023
Glioblastoma is the most common and aggressive form of primary brain cancer and the lack of viable treatment options has created an urgency to develop novel treatments. Personalized or predictive medicine is still in its infancy stage at present.
Junying Liu, Ruixin Wu, Shouli Yuan, Robbie Kelleher, Siying Chen, Rongfeng Chen, Tao Zhang, Ismael Obaidi, Helen Sheridan   +8 more
doaj   +1 more source