Results 11 to 20 of about 581,117 (305)

Drug Repositioning Applied to Cardiovascular Disease in Mucopolysaccharidosis

Life, 2022
Mucopolysaccharidoses (MPS) are genetic metabolic diseases characterized by defects in the activity of lysosomal hydrolases. In MPS, secondary cell disturbance affects pathways related to cardiovascular disorders.
Gerda Cristal Villalba Silva, Thiago Steindorff, Roselena Silvestri Schuh, Natalia Cardoso Flores, Ursula Matte   +4 more
doaj   +1 more source

Systems Pharmacology [PDF]

Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, 2010
AbstractWe examine how physiology and pathophysiology are studied from a systems perspective, using high‐throughput experiments and computational analysis of regulatory networks. We describe the integration of these analyses with pharmacology, which leads to new understanding of drug action and enables drug discovery for complex diseases.
Aislyn D W, Boran, Ravi, Iyengar
openaire   +2 more sources

How Aconiti Radix Cocta can Treat Gouty Arthritis Based on Systematic Pharmacology and UPLC-QTOF-MS/MS

Frontiers in Pharmacology, 2021
Background: Gouty arthritis (GA) is a common metabolic disease caused by a long-term disorder of purine metabolism and increased serum levels of uric acid.
Xietao Ye, Jianxiong Wu, Dayong Zhang, Zelun Lan, Songhong Yang, Jing Zhu, Ming Yang, Qianfeng Gong, Lingyun Zhong   +8 more
doaj   +1 more source

Rewiring Drug Research and Development through Human Data-Driven Discovery (HD³)

Pharmaceutics, 2023
In an era of unparalleled technical advancement, the pharmaceutical industry is struggling to transform data into increased research and development efficiency, and, as a corollary, new drugs for patients.
David B. Jackson, Rebecca Racz, Sarah Kim, Stephan Brock, Keith Burkhart   +4 more
doaj   +1 more source

Systems Pharmacology of Arrhythmias [PDF]

Science Signaling, 2010
Integration of drug and protein interaction data with genetic data enables prediction of adverse drug effects.
Seth I, Berger, Avi, Ma'ayan, Ravi, Iyengar   +2 more
openaire   +2 more sources

Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment

Frontiers in Pharmacology, 2022
In the tumor microenvironment (TME), the activation of programmed death-1 (PD-1)–programmed death ligand-1 (PD-L1) pathway is one of the main signals of immune escape and tumor deterioration.
Ruijie Yang, Tianli Pei, Ruifei Huang, Yue Xiao, Jiangna Yan, Jinglin Zhu, Chunli Zheng, Wei Xiao, Chao Huang, Chao Huang   +9 more
doaj   +1 more source

Cardiorenal Systems Modeling: Left Ventricular Hypertrophy and Differential Effects of Antihypertensive Therapies on Hypertrophy Regression

Frontiers in Physiology, 2021
Cardiac and renal function are inextricably connected through both hemodynamic and neurohormonal mechanisms, and the interaction between these organ systems plays an important role in adaptive and pathophysiologic remodeling of the heart, as well as in ...
K. Melissa Hallow, Charles H. Van Brackle, Sommer Anjum, Sergey Ermakov   +3 more
doaj   +1 more source

Systems Pharmacology Study of the Anti-Liver Injury Mechanism of Citri Reticulatae Pericarpium

Frontiers in Pharmacology, 2021
Liver diseases are mostly triggered by oxidative stress and inflammation, leading to extracellular matrix overproduction and prone to develop into liver fibrosis, cirrhosis and hepatocellular carcinoma.
Jianxiong Wu, Xietao Ye, Songhong Yang, Huan Yu, Lingyun Zhong, Qianfeng Gong   +5 more
doaj   +1 more source

Transcriptional Activation, Deactivation and Rebound Patterns in Cortex, Hippocampus and Amygdala in Response to Ketamine Infusion in Rats

Frontiers in Molecular Neuroscience, 2022
Ketamine, an N-methyl-D-aspartate (NMDA)-receptor antagonist, is a recently revitalized treatment for pain and depression, yet its actions at the molecular level remain incompletely defined.
Jenny J. Kim, Matthew R. Sapio, Fernando A. Vazquez, Dragan Maric, Amelia J. Loydpierson, Wenting Ma, Carlos A. Zarate, Michael J. Iadarola, Andrew J. Mannes   +8 more
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Transcriptomics, Cheminformatics, and Systems Pharmacology Strategies Unveil the Potential Bioactives to Combat COVID-19

Molecules, 2022
Coronavirus disease (COVID-19) is a viral disease caused by the SARS-CoV-2 virus and is becoming a global threat again because of the higher transmission rate and lack of proper therapeutics as well as the rapid mutations in the genetic pattern of SARS ...
Sivakumar Adarshan, Sakthivel Akassh, Krishnakumar Avinash, Mathivanan Bharathkumar, Pandiyan Muthuramalingam, Hyunsuk Shin, Venkidasamy Baskar, Jen-Tsung Chen, Veluswamy Bhuvaneshwari, Manikandan Ramesh   +9 more
doaj   +1 more source