Results 31 to 40 of about 581,117 (305)

Optimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing

Frontiers in Pharmacology, 2022
In the era of “Bad Bugs, No Drugs,” optimizing antibiotic therapy against multi-drug resistant (MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize dosing regimens.
Hui-Yin Yow, Hui-Yin Yow, Kayatri Govindaraju, Audrey Huili Lim, Nusaibah Abdul Rahim   +4 more
doaj   +1 more source

BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology. [PDF]

, 2015
BindingDB, www.bindingdb.org, is a publicly accessible database of experimental protein-small molecule interaction data. Its collection of over a million data entries derives primarily from scientific articles and, increasingly, US patents.
Baitaluk, Michael, Chong, Jenny, Gilson, Michael K, Hwang, Linda, Liu, Tiqing, Nicola, George   +5 more
core   +1 more source

Potential antidepressant effects of scutellaria baicalensis, hericium erinaceus and rhodiola rosea [PDF]

, 2020
Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Accordingly, bioactive ingredients which are found within a variety of
Biagioni, F, Busceti, CL, Fabrizi, C, Fornai, F, Limanaqi, F, Polzella, M   +5 more
core   +2 more sources

An Integrated Pharmacokinetic Study of an Acanthopanax senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats

Frontiers in Pharmacology, 2020
In this paper, the integrated pharmacokinetics (PK) of an Acanthopanax senticosus extract preparation (ASEP, named as Ciwujia injection in clinic in China) was explored by combining with multi-component PK in rats, virtual screening, systems pharmacology
Peiying Shi, Peiying Shi, Yunjiao Xie, Rongfang Xie, Zuan Lin, Hong Yao, Shuang Wu   +6 more
doaj   +1 more source

Combination of Systems Pharmacology and Experimental Evaluation to Explore the Mechanism of Synergistic Action of Frankincense-Myrrh in the Treatment of Cerebrovascular Diseases

Frontiers in Pharmacology, 2022
Frankincense-Myrrh is a classic drug pair that promotes blood circulation, and eliminates blood stasis. The combination of the two drugs has a definite clinical effect on the treatment of cerebrovascular diseases (CBVDs), but its mechanism of action and ...
Yucheng Liao, Yucheng Liao, Jingwen Wang, Chao Guo, Min Bai, Bowei Ju, Zheng Ran, Junping Hu, Jianhua Yang, Jianhua Yang, Aidong Wen, Yi Ding   +11 more
doaj   +1 more source

Editorial: Systems pharmacology in the spotlight: trending technologies in network biology and drug discovery [PDF]

Frontiers in Pharmacology
Raghuveera Kumar Goel, Kiven Erique Lukong, Andrew Emili   +2 more
doaj   +2 more sources

ATP as a presynaptic modulator [PDF]

, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source

A Framework for Simplification of Quantitative Systems Pharmacology Models in Clinical Pharmacology [PDF]

British Journal of Clinical Pharmacology, 2020
Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and simulation that has gained wide attention over the past few years. The application of QSP models spans drug‐target identification and validation, through all drug development phases as well as clinical applications.
Abdallah Derbalah, Hesham Al‐Sallami, Chihiro Hasegawa, Abhishek Gulati, Stephen B. Duffull   +4 more
openaire   +2 more sources

Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on network pharmacology and experimental exploration

Frontiers in Microbiology, 2022
ObjectiveTo investigate the active ingredients, underlying anti-influenza virus effects, and mechanisms of Huoxiang Suling Shuanghua Decoction (HSSD).Materials and methodsThe therapeutic effect of HSSD were confirmed through the survival rate experiment ...
Ruying Tang, Linyuan Wang, Jianjun Zhang, Xinyu Li, Lingyun Tan, Wei He, Hui Han, Yuan Liu, Yuan Liu, Keyu Wang, Mengyao Wang   +10 more
doaj   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source