Results 51 to 60 of about 581,117 (305)

THE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY [PDF]

Alcohol and Alcoholism, 2004
The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared early in evolution and which has important regulatory functions throughout the body in all vertebrates. The main endocannabinoids (endogenous cannabis-like substances) are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2 ...
Fernando, Rodríguez de Fonseca, Ignacio, Del Arco, Francisco Javier, Bermudez-Silva, Ainhoa, Bilbao, Andrea, Cippitelli, Miguel, Navarro   +5 more
openaire   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

UHPLC-Q-Orbitrap HRMS and network analysis to explore the mechanisms of QiShenYiQi dripping pill for treating myocardial infarction

Frontiers in Pharmacology
This study focused on examining the protection of QiShenYiQi dripping pills (QSYQ) against myocardial infarction (MI) and investigating its potential mechanisms.
Zhichao Liu, Huanjie Fu, Yongkang Gan, Yujia Ye, Binghui Huang, Mingxiu Jiang, Jinhong Chen, Xiaofeng Li   +7 more
doaj   +1 more source

Angelica Dahurica Regulated the Polarization of Macrophages and Accelerated Wound Healing in Diabetes: A Network Pharmacology Study and In Vivo Experimental Validation

Frontiers in Pharmacology, 2021
Diabetic wounds exhibit retarded and partial healing processes. Therefore, patients are exposed to an elevated risk of infection. It has been verified that Angelica dahurica (Hoffm.) Benth. and Hook. f. ex Franch. and Sav (A.
Yonghui Hu, Sisi Lei, Sisi Lei, Zhiyue Yan, Zhibo Hu, Jun Guo, Hang Guo, Bei Sun, Congqing Pan   +8 more
doaj   +1 more source

GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field [PDF]

, 2016
Quantitative Systems Pharmacology (QSP) is experiencing increased application in the drug discovery and development process. Like its older sibling, systems biology, the QSP field is comprised of a mix of established disciplines and methods, from ...
Abernethy, DR, Allerheiligen, SR, Lauffenburger, Douglas A, Musante, CJ, Zager, MG   +4 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

A chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells

Molecular Systems Biology, 2015
Small molecules often affect multiple targets, elicit off‐target effects, and induce genotype‐specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effects across a broad spectrum of phenotypes can identify ...
Marco Breinig, Felix A Klein, Wolfgang Huber, Michael Boutros   +3 more
doaj   +1 more source

Investigation of the Multi-Target Mechanism of Guanxin-Shutong Capsule in Cerebrovascular Diseases: A Systems Pharmacology and Experimental Assessment

Frontiers in Pharmacology, 2021
Guanxin-Shutong capsule (GXSTC), a combination of Mongolian medicines and traditional herbs, has been clinically proven to be effective in treating cerebrovascular diseases (CBVDs).
Juanli Zhang, Juanli Zhang, Jiaxin Zhao, Yang Ma, Wenjun Wang, Shaojie Huang, Chao Guo, Kai Wang, Xiaomei Zhang, Wei Zhang, Aidong Wen, Ming Shi, Yi Ding   +12 more
doaj   +1 more source

Assessing Cognitive Functioning in Children With Brain Tumors: Interaction of Neighborhood Social Determinants of Health and Neurological Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich, Manali Zope, Peter M. Fantozzi, Cassie N. Kline, Iris Paltin, Matthew C. Hocking   +5 more
wiley   +1 more source

Systems Pharmacology Approach and Experiment Evaluation Reveal Multidimensional Treatment Strategy of LiangXueJieDu Formula for Psoriasis

Frontiers in Pharmacology, 2021
Clinical studies have demonstrated the anti-psoriatic effect of the LiangXueJieDu (LXJD) herbal formula. However, the systemic mechanism and the targets of the LXJD formula have not yet been elucidated.
Jingxia Zhao, Jingxia Zhao, Yan Wang, Yan Wang, Weiwen Chen, Jing Fu, Jing Fu, Yu Liu, Yu Liu, Yu Liu, Tingting Di, Tingting Di, Cong Qi, Cong Qi, Zhaoxia Chen, Zhaoxia Chen, Ping Li, Ping Li   +17 more
doaj   +1 more source