Results 61 to 70 of about 581,117 (305)

The effects of species ortholog and SNP variation on receptors for free fatty acids [PDF]

, 2013
Although it is widely assumed that species orthologs of hormone responsive G protein-coupled receptors will be activated by the same endogenously produced ligand(s), variation in potency, particularly in cases where more than one receptor responds to the
1000 Genomes Project Consortium, Bellahcene, Bergman, Bjursell, Blad, Brian D. Hudson, Briscoe, Brown, Burant, Christiansen, Christiansen, Christiansen, Christiansen, Cummings, Edfalk, Fredriksson, Galindo, Ge, Graeme Milligan, Hamid, Hannah Murdoch, Hirasawa, Hong, Hudson, Hudson, Hudson, Hudson, Humphries, Ichimura, Insel, Itoh, Kaku, Kalis, Kebede, Kebede, Kimura, Lan, Latour, Le Poul, Leonard, Liaw, Lin, Luo, Maslowski, Milligan, Milligan, Moore, Negoro, Ogawa, Oh, Ryan, Sawzdargo, Schmidt, Shimpukade, Sina, Smith, Smith, Steneberg, Stoddart, Stoddart, Strasser, Sum, Tan, Taneera, Tolhurst, Vettor, Watson, Wolever, Xiong, Xiong, Yashiro, Zaibi, Zhou   +72 more
core   +1 more source

Systemic pharmacological interventions for Ménière’s disease

Cochrane Database of Systematic Reviews, 2021
Ménière's disease is a condition that causes recurrent episodes of vertigo, associated with hearing loss and tinnitus. A number of pharmacological interventions have been used in the management of this condition, including betahistine, diuretics, antiviral medications and corticosteroids.
Webster, Katie E, Galbraith, Kevin, Harrington-Benton, Natasha A, Judd, Owen, Kaski, Diego, Maarsingh, Otto R, MacKeith, Samuel, Ray, Jaydip, Van Vugt, Vincent A, Burton, Martin J   +9 more
openaire   +5 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Leveraging network pharmacology in the treatment of asthma

ADMET and DMPK
Background and purpose: Asthma, a chronic airway inflammatory disorder driven by multifaceted genetic, cellular and molecular interactions, remains inadequately managed by single-target therapies due to incomplete disease control and adverse effects ...
Sarthi Ahuja , Richard Cherehani Kashindye , Divya Yadav, Priyanka Chaudhary, Rakesh Yadav   +4 more
doaj   +1 more source

Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoarthritis: Role of Transient Receptor Potential Channels

Pharmaceuticals, 2021
Systems pharmacology employs computational and mathematical methods to study the network of interactions a drug may have within complex biological pathways.
Jakub Mlost, Marta Kędziora, Katarzyna Starowicz   +2 more
doaj   +1 more source

Process Improvement for Maximized Therapeutic Innovation Outcome. [PDF]

, 2017
Deconvoluting key biological mechanisms forms the framework for therapeutic discovery. Strategies that enable effective translation of those insights along the development and regulatory path ultimately drive validated clinical application in patients ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]

, 2020
Inflammatory mediators may have a role in various lower urinary tract disorders. Histamine is known to induce significant increases in both the tension and frequency of spontaneous phasic contractions in both urothelium with lamina propria (U&LP) and
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases

Anais da Academia Brasileira de Ciências
: Cardiovascular diseases (CVDs) are leading causes of death in the world, owing to noticeable incidence and mortality. Traditional Chinese Medicine (TCM) SINI Decoction (SND) is used to prevent and treat CVDs, which has attracted extensive attention for
ZHIMING SHU, TIANTIAN WU, MOHAMED SHAHEN, ZIHU GUO, JIA SHU, HE WANG, AKHTAR H. SHAR, MAYADA R. FARAG, MAHMOUD ALAGAWANY, MOHAMED E. ABD EL-HACK, CHAOBIN LIU   +10 more
doaj   +1 more source