Results 71 to 80 of about 581,117 (305)

Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems

Frontiers in Pharmacology, 2020
Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-orientated, single target, and conventional antidepressants are insufficient and far from ideal.
Chan Li, Chan Li, Junying Huang, Yung-Chi Cheng, Yuan-Wei Zhang, Yuan-Wei Zhang   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

System dynamics modelling in systems biology and applications in pharmacology [PDF]

, 2018
El modelado matemático de sistemas biológicos complejos es uno de los temas clave en la Biología de Sistemas y varios métodos computacionales basados ​​en la simulación computarizada han sido aplicados hasta ahora para determinar el comportamiento de los
Fernández, F. Javier, Fernández-de-Cañete-Rodríguez, Francisco Javier, Ramos Díaz, J. Carlos   +2 more
core  

Analyzing Medication Documentation in Electronic Health Records: Dental Students’ Self-Reported Behaviors and Charting Practices [PDF]

, 2019
The aim of this two-part study was to assess third- and fourth-year dental students’ perceptions, self-reported behaviors, and actual charting practices regarding medication documentation in axiUm, the electronic health record (EHR) system.
Burcham, Wesley K., Gitter, Bruce D., Moser, Elizabeth A., Romito, Laura M.   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

From In Vitro Efficacy to Long‐Term HbA1c Response for GLP‐1R/GlucagonR Agonism Using the 4GI‐HbA1c Systems Model

CPT: Pharmacometrics & Systems Pharmacology
For the treatment of Type 2 Diabetes, high efficacy approaches such as Glucagon‐like peptide 1 (GLP‐1)‐based therapies are recommended for glucose control. Prediction of the clinical outcome of these therapies on glucose and hemoglobin A1c (HbA1c), using
Rolien Bosch, Marcella Petrone, Rosalin Arends, Eric J. G. Sijbrands, Sven Hoefman, Nelleke Snelder   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Drugs Affecting 5-HT Systems [PDF]

, 2013
Seminar transcriptIt was in the very early hours of a February morning in 1977 that I first looked down the microscope and saw yellow fluorescence, characteristic of 5-hydroxytryptamine (5-HT) in frozen sections of Octopus brain. After struggling for two
Overy, C, Tansey, EM
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Systems Pharmacology and Verification of ShenFuHuang Formula in Zebrafish Model Reveal Multi-Scale Treatment Strategy for Septic Syndrome in COVID-19

Frontiers in Pharmacology, 2020
The outbreak of coronavirus disease 2019 (COVID-19) has affected millions of people worldwide. Critically ill COVID-19 patients develop viral septic syndrome, including inflammatory damage, immune dysfunction, and coagulation disorder.
Tengwen Liu, Yuhong Guo, Yuhong Guo, Jingxia Zhao, Jingxia Zhao, Shasha He, Shasha He, Yunjing Bai, Yunjing Bai, Ning Wang, Ning Wang, Yan Lin, Yan Lin, Qingquan Liu, Qingquan Liu, Xiaolong Xu, Xiaolong Xu   +16 more
doaj   +1 more source