Results 51 to 60 of about 46,548 (264)

Identification of Potential Mechanisms of Rk1 Combination with Rg5 in the Treatment of Type II Diabetes Mellitus by Integrating Network Pharmacology and Experimental Validation

, 2023
In this study, we aimed to explore the potential targets and functional mechanisms of Rk1 combined with Rg5 (Rk1+Rg5) against type II diabetes mellitus (T2DM).
Wenjiao Xue, Yao Liu, Hao Ding, Chen Liu, Chao An, Qiwen Zhang, Jingjing Zhang, Saijian Ma   +7 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Chinese Medicine, 2021
Background Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic cancer (PC) treatment has not been
Chao Wu, Zhi-Hong Huang, Zi-Qi Meng, Xiao-Tian Fan, Shan Lu, Ying-Ying Tan, Lei-Ming You, Jia-Qi Huang, Antony Stalin, Pei-Zhi Ye, Zhi-Shan Wu, Jing-Yuan Zhang, Xin-Kui Liu, Wei Zhou, Xiao-Meng Zhang, Jia-Rui Wu   +15 more
doaj   +1 more source

The potential of translational bioinformatics approaches for pharmacology research.

, 2015
The field of bioinformatics has allowed the interpretation of massive amounts of biological data, ushering in the era of ‘omics’ to biomedical research.
Li, Lang
core   +1 more source

Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation [PDF]

, 2022
The evolving view of gut microbiota has shifted toward describing the colonic flora as a dynamic organ in continuous interaction with systemic physiologic processes.
AlZaim, Ibrahim, El-Yazbi, Ahmed F., El-Yazbi, Ahmed, Dwaib, Haneen S., Eid, Ali H., Ajouz, Ghina   +5 more
core   +1 more source

Molecular and clinical pharmacology of psoriasis [PDF]

Clinical Pharmacology & Therapeutics, 1974
Psoriasis appears in most cases to be a genetic disease8 in which stratified squamous epithelium (epidermis) of skin in involved versus normal‐appearing uninvolved areas has the following prototypic features: (1) excessive cell proliferation and an accelerated cell cycle of the proliferating cells21; (2) incomplete epidermal specialization ...
Voorhees, John J., Duell, Elizabeth A., Stawiski, Marek, Harrell, E. Richard   +3 more
openaire   +3 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Integrating Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Hydroxysafflor Yellow A in Delaying Liver Aging

, 2022
Aging affects the structure and function of the liver. Hydroxysafflor yellow A (HSYA) effectively improves liver aging (LA) in mice, but the potential mechanisms require further exploration.
Haiyan Li, Hu, Xingli, Siming Sun, Kong, Jie, Cheng, Yan, Jie Kong, Xingli Hu, Xiaojie Wang, Li, Haiyan, Fei Min, Yan Cheng, Zhang, Yuan, Xin Liu, Yuan Zhang, Liu, Xin, Sun, Siming, Min, Fei, Wang, Xiaojie   +17 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

High-resolution view of compound promiscuity [v1; ref status: indexed, http://f1000r.es/1dg]

F1000Research, 2013
Compound promiscuity is defined as the ability of a small molecule to specifically interact with multiple biological targets. So-defined promiscuity is relevant for drug discovery because it provides the molecular basis of polypharmacology, which is ...
Ye Hu, Jürgen Bajorath
doaj   +1 more source