Results 261 to 270 of about 247,999 (295)

Cholesterol‐dependent modulation of type 1 cannabinoid receptors in nerve cells

Journal of Neuroscience Research, 2005
AbstractType 1 cannabinoid receptors (CB1R) are G‐protein‐coupled receptors that mediate several actions of the endocannabinoid anandamide (N‐arachidonoylethanolamine; AEA) in the central nervous system. Here we show that cholesterol enrichment of rat C6 glioma cell membranes reduces by approximately twofold the binding efficiency (i.e., the ratio ...
Bari M, Paradisi A, Pasquariello N, Maccarrone M   +3 more
openaire   +4 more sources

Cannabinoid receptor 2 (CB2) modulators: A patent review (2016–2024)

Bioorganic Chemistry
Cannabinoid receptors CB1 and CB2 play critical roles in regulating numerous central and peripheral physiological activities. While efforts have been made to develop ligands for both CB1 and CB2 receptors, CB1 receptor ligands often have restricted use due to undesirable psychotropic side effects. Consequently, recent cannabis research has increasingly
Rayees Ahmad, Naikoo, Ritu, Painuli, Zaheen, Akhter, Parvinder Pal, Singh   +3 more
openaire   +2 more sources

Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor.

Angewandte Chemie, 2018
Noureldin Saleh, O. Hucke, G. Kramer, Esther Schmidt, F. Montel, Radosław Lipiński, B. Ferger, Timothy Clark, P. Hildebrand, C. Tautermann   +9 more
semanticscholar   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Breast Cancer Statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Hyuna Sung, Kimberly D Miller, Rebecca L Siegel   +2 more
exaly  

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

Nature Chemical Biology, 2019
Zhenhua Shao, Wei-Qun Yan, Karen M. Chapman, Karthik Ramesh, A. Ferrell, Jie Yin, Xuehui Wang, Qingping Xu, D. Rosenbaum   +8 more
semanticscholar   +1 more source

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Victoria Metaxa, Elie Azoulay   +2 more
exaly  

In silico mapping of allosteric ligand binding sites in type‐1 cannabinoid receptor

Biotechnology and applied biochemistry, 2018
A. Sabatucci, D. Tortolani, E. Dainese, M. Maccarrone   +3 more
semanticscholar   +1 more source