Results 41 to 50 of about 56,314 (199)

Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist

Life, 2020
Preclinical studies highlighted that compounds targeting cannabinoid receptors could be useful for developing novel therapies against neurodegenerative disorders.
Beatrice Polini, Chiara Cervetto, Sara Carpi, Simone Pelassa, Francesca Gado, Rebecca Ferrisi, Simone Bertini, Paola Nieri, Manuela Marcoli, Clementina Manera   +9 more
doaj   +1 more source

Cannabinoid receptors in invertebrates [PDF]

Journal of Evolutionary Biology, 2006
Abstract Two cannabinoid receptors, CB1 and CB2, are expressed in mammals, birds, reptiles, and fish. The presence of cannabinoid receptors in invertebrates has been controversial, due to conflicting evidence. We conducted a systematic review of the literature, using expanded search parameters. Evidence presented in the literature varied
J M, McPartland, J, Agraval, D, Gleeson, K, Heasman, M, Glass   +4 more
openaire   +2 more sources

Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies

Frontiers in Pharmacology, 2015
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes
Katia eBefort
doaj   +1 more source

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s) [PDF]

, 2015
ACKNOWLEDGMENTS The work was supported by National Institutes of Health grants DA027113 and EY024717 to G.A.T. and DA09158 to A.M. A portion of this work was submitted in 2011 by A. Kulkarni in partial fulfillment of M.S.
Cascio, Maria G., Denovan-Wright, Eileen M., Janero, David R., Korde, Anisha, Kulkarni, Abhijit R., Kulkarni, Pushkar M., Laprairie, Robert B., Makriyannis, Alexandros, Pertwee, Roger G., Thakur, Ganesh A., Tichkule, Ritesh B., Zhou, Han, Zvonok, Nikolai   +12 more
core   +3 more sources

Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells.

PLoS ONE, 2008
BackgroundWhile cannabinoids have been shown to ameliorate liver fibrosis, their effects in chronic pancreatitis and on pancreatic stellate cells (PSC) are unknown.Methodology/principal findingsThe activity of the endocannabinoid system was evaluated in ...
Christoph W Michalski, Milena Maier, Mert Erkan, Danguole Sauliunaite, Frank Bergmann, Pal Pacher, Sandor Batkai, Nathalia A Giese, Thomas Giese, Helmut Friess, Jörg Kleeff   +10 more
doaj   +1 more source

In Vitro Signaling Properties of Cannabinoid and Orexin Receptors: How Orexin Receptors Influence Cannabinoid Receptor‐Mediated Signaling

Pharmacology Research & Perspectives
The co‐expression of different types of G protein‐coupled receptors (GPCRs) in the same cells can have implications for receptor signaling and receptor cross‐talk, potentially altering the apparent potency or efficacy of ligands targeting each receptor ...
Kawthar A. Mohamed, Robert B. Laprairie
doaj   +1 more source

The Impact of CB1 Receptor on Inflammation in Skeletal Muscle Cells

Journal of Inflammation Research, 2021
Mansour Haddad Faculty of Pharmacy, Philadelphia University, Amman, JordanCorrespondence: Mansour Haddad Email Dr.man.haddad@gmail.comBackground: Various factors trigger the inflammatory response and cytokine activation in skeletal muscle.
Haddad M
doaj  

Dendritic Cell Regulation by Cannabinoid-Based Drugs

Pharmaceuticals, 2010
Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have produced promising results using cannabinoid-based drugs for the treatment of obesity and ...
Mattias Svensson, Puran Chen, Oscar Hammarfjord   +2 more
doaj   +1 more source

Cannabinoid type 1 receptors transiently silence glutamatergic nerve terminals of cultured cerebellar granule cells. [PDF]

PLoS ONE, 2014
Cannabinoid receptors are the most abundant G protein-coupled receptors in the brain and they mediate retrograde short-term inhibition of neurotransmitter release, as well as long-term depression of synaptic transmission at many excitatory synapses.
Jorge Ramírez-Franco, David Bartolomé-Martín, Beatris Alonso, Magdalena Torres, José Sánchez-Prieto   +4 more
doaj   +1 more source

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain [PDF]

, 2006
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Barrett, David, Chapman, Victoria, Jhaveri, Maulik, Kendall, David, Richardson, Denise   +4 more
core   +2 more sources