Results 151 to 160 of about 47,203 (289)
British Journal of Pharmacology, EarlyView.Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović +6 more
wiley +1 more source
The Development of a Simple Liquid Chromatography‐Precursor Ion Scan‐Mass Spectrometry Screening Method for the Detection of Phytocannabinoids in Plant Extracts [PDF]
J Mass SpectromABSTRACT Screening of major cannabinoids in cannabis‐derived extracts is needed when these extracts are applied in pharmacological and biological studies. Precursor ion scan‐mass spectrometry (PIS‐MS) is a viable approach for the detection and screening of major cannabinoids through characteristic MS/MS fragmentation behavior.
Mahmoud R +5 more
europepmc +2 more sources
The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Athletes and Medical Staff in Elite Contact Sports: a Quantitative Analysis of Use, Knowledge, and Attitudes Regarding Cannabinoids. [PDF]
Sports HealthThompson ES +5 more
europepmc +1 more source
The FEBS Journal, EarlyView.Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta +1 more
wiley +1 more source
Effects of phytocannabinoids, synthetic and semi-synthetic cannabinoids on microglia and astrocytes: Review of neuroinflammatory mechanisms. [PDF]
J Neuropathol Exp NeurolBrambilla G +4 more
europepmc +1 more source
Novel targets in headache: A narrative review
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra +5 more
wiley +1 more source
The Howard Journal of Crime and Justice, EarlyView.ABSTRACT This article presents an analysis of surveys conducted by HM Inspectorate of Prisons for England and Wales of 87,449 adult male prisoners between the years 2000 and 2020. It describes the survey methodology and focuses on the 13,025 people who reported feeling unsafe.
Nicholas Hardwick +2 more
wiley +1 more source
Journal of Paediatrics and Child Health, EarlyView.ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating +7 more
wiley +1 more source