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Tetrahydrocannabinol and acetylcholinesterase
Pharmacology Biochemistry and Behavior, 1978Recent evidence suggests that the psychoactive effect of delta-9-tetrahydrocannabinol (delta9-THC), the major psychoactive constituent of marihuana, may be mediated through an alteration of cholinergic neurotransmission. One possible mechanism by which delta9-THC could have its effect is by affecting acetylcholinesterase (AChE) and there is evidence ...
D E, Moss, P L, Peck, R, Salome
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Synthetic Tetrahydrocannabinol
Journal of Forensic Sciences, 1983Abstract This paper presents the synthetic route used and the identification of the precursors and reaction products in a clandestine laboratory manufacture of cannabidiol (CBD), μ9-cis-tetrahydrocannabinol (μ9)-cis-THC), and μ9-trans-tetrahydrocannabinol (μ9-trans-THC).
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Stability of Tetrahydrocannabinols II
Journal of Pharmaceutical Sciences, 1978The biphasic degradation of delta9-tetrahydrocannabinol (I), as monitored by flame-ionization GLC, produced delta8-tetrahydrocannabinol (II), cannabidiol (X), 9-hydroxyhexahydrocannabinol (VI), 9,10-dihydro-9-hydroxyisocannabidiol (VI), and and 6,12-dihydro-6-hydroxycannabidiol (VIII) in acidic solutions.
E R, Garrett, A J, Gouyette, H, Roseboom
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Psychological Effects of Tetrahydrocannabinol
Archives of General Psychiatry, 1970THE MORE widespread use of marihuana and marihuana-like drugs in the general population and the controversy about their possible harmful, as well as beneficial, effects have led to an increased interest in studying these compounds during the last few years.
I E, Waskow +3 more
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Phytocannabinoids: Tetrahydrocannabinol (THC)
2021Cannabis includes several species, the popular ones being Cannabis sativa, Cannabis indica, and Cannabis ruderalis. Cannabinoids are chemicals either derived from cannabis (phytocannabinoids) like cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC); synthetic medications like nabilone, dronabinol, and rimonabant; or endogenous chemicals that stimulate ...
Priodarshi Roychoudhury +2 more
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Stability of Tetrahydrocannabinols I
Journal of Pharmaceutical Sciences, 1974Δ9-Tetrahydrocannabinol, as monitored by flame-ionization GLC at various temperatures, degrades by a biphasic semilogarithmic curve with time in acidic aqueous solutions (
E R, Garrett, J, Tsau
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Intravenous Δ9-Tetrahydrocannabinol
Anesthesiology, 1975Delta9-Tetrahydrocannabinol (THC), the active component of marijuana, was studies to determine whether it might be useful for preanesthetic medication. Ten healthy subjects received THC intravenously in logarithmically spaced incremental doses. Four subjects received a total cumulatine dose of 135 mug/kg and four others, 201 mug/kg, Two of the ten ...
Lee A. Malit +5 more
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Life Sciences, 1973
The hypothermic activity of Δ9-tetrahydrocannabinol (Δ9-THC), a metabolite, 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-Δ9-THC) and 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC) has been determined in male mice maintained at an ambient temperature of 20 ± 1°C. The mean body temperature of mice that received 2, 4, 16 or 32 mg/kg, i.
C O, Haavik, H F, Hardman
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The hypothermic activity of Δ9-tetrahydrocannabinol (Δ9-THC), a metabolite, 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-Δ9-THC) and 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC) has been determined in male mice maintained at an ambient temperature of 20 ± 1°C. The mean body temperature of mice that received 2, 4, 16 or 32 mg/kg, i.
C O, Haavik, H F, Hardman
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