Results 41 to 50 of about 20,460 (225)

Cannabis and Anxiety: A Critical Review

Medical Cannabis and Cannabinoids
Introduction: Cannabis has been reported to have both anxiogenic and anxiolytic effects. Habitual cannabis use has been associated with anxiety disorders (AD).
Alexander Beletsky, Cherry Liu, Bryson Lochte, Nebiyou Samuel, Igor Grant   +4 more
doaj   +1 more source

Priority areas for cannabis and cannabinoid product research in South Africa

African Journal of Primary Health Care & Family Medicine, 2018
No abstract available.
Tanya N. Augustine, Carel J. Cairns, Sean Chetty, Lisa G. Dannatt, Nadine Gravett, Glenda Grey, Gerhard Grobler, Zukiswa Jafta, Peter Kamerman, John Lopes, Motlalepula G. Matsabisa, Pierre Mugabo, Michelle Mulder, Charles Parry, Solomon Rataemane, Nandi Siegfried, Vanessa Steenkamp, Eileen Thomas, Richard van Zyl-Smit   +18 more
doaj   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Cross-sectional comparison of cannabis use in adults with neuropathic versus non-neuropathic pain

Frontiers in Pain Research
IntroductionCannabis has been decriminalized by many states and shows promise in treating both neuropathic and non-neuropathic pain through its interaction with the endocannabinoid system and anti-inflammatory effects.
Carl Joshua P. Laroya, Carl Joshua P. Laroya, Crystal Lederhos Smith, Ross J. Bindler, Michael G. McDonell, Jamie Lewis, Jamie Lewis, Marian Wilson   +7 more
doaj   +1 more source

Propagation of Cannabis for Clinical Research: An Approach Towards a Modern Herbal Medicinal Products Development

Frontiers in Plant Science, 2020
Cannabis has been reported to contain over 560 different compounds, out of which 120 are cannabinoids. Among the cannabinoids, Δ9-tetrahydrocannabinol and cannabidiol are the two major compounds with very different pharmacological profile and a ...
Suman Chandra, Hemant Lata, Mahmoud A. ElSohly, Mahmoud A. ElSohly   +3 more
doaj   +1 more source

Network-Based Pharmacology Study Reveals Protein Targets for Medical Benefits and Harms of Cannabinoids in Humans

Applied Sciences, 2022
This network-based pharmacology study intends to uncover the underlying mechanisms of cannabis leading to a therapeutic benefit and the pathogenesis for a wide range of diseases claimed to benefit from or be caused by the use of the cannabis plant ...
Xingyu Li, Amit Madhukar Kudke, Felix Joseph Nepveux V, Yan Xu   +3 more
doaj   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Methods for GC/MS Analysis of the Most Commonly Seized Drugs of Abuse and Their Metabolites in Biological Samples

Chemosensors
Gas chromatography with mass spectrometry (GC-MS) is a common analytical technique used for identifying and quantifying drugs of abuse, as well as their metabolites, extracted from biological samples. Depending on the properties of the analyzed compounds,
Ivan Kojić, Violeta M. Đurović, Yulia A. Smyatskaya, Nemanja Brkljača, Angi E. Skhvediani, Andrey V. Vasin, Ksenija Stojanović, Saša D. Đurović   +7 more
doaj   +1 more source

Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions

Medicines, 2018
Background: We use a mobile software application (app) to measure for the first time, which fundamental characteristics of raw, natural medical Cannabis flower are associated with changes in perceived insomnia under naturalistic conditions. Methods: Four
Jacob M. Vigil, Sarah S. Stith, Jegason P. Diviant, Franco Brockelman, Keenan Keeling, Branden Hall   +5 more
doaj   +1 more source

Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?

Pharmaceutics, 2021
The most important discoveries in pharmacology, such as certain classes of analgesics or chemotherapeutics, started from natural extracts which have been found to have effects in traditional medicine.
Leontina Elena Filipiuc, Daniela Carmen Ababei, Teodora Alexa-Stratulat, Cosmin Vasilica Pricope, Veronica Bild, Raluca Stefanescu, Gabriela Dumitrita Stanciu, Bogdan-Ionel Tamba   +7 more
doaj   +1 more source