Results 51 to 60 of about 30,694 (295)

Cross-tolerance development to the prolongation of pentobarbitone-induced sleep by Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol in mice

, 1987
Repeated administration (5 mg kg−1 day−1 i.v.) of Δ8-tetrahydrocannabinol and its active metabolite, 11-hydroxy-Δ8-tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone-induced sleep in mice.
H Yoshimura, K Watanabe, S Narimatsu, I Yamamoto   +3 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Influência do delta9 -tetrahidrocanabiol sobre a aprendizagem/memória e tolerância avaliadas em camundongos no labirinto aquático e teste do rota-rod / [PDF]

, 2000
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.Conhecendo-se os efeitos do principal constituinte psicoativo da maconha, [D9-tetrahidrocanabinol (D9-THC)], sobre o aprendizado e memória, e a capacidade da ...
Silva, George Ernesto da
core  

Identification of Candidate Genes Affecting ∆⁹-tetrahydrocannabinol Biosynthesis in Cannabis sativa [PDF]

, 2009
Article discussing the identification of candidate genes affecting ∆⁹-tetrahydrocannabinol biosynthesis in Cannabis ...
Weiblen, George D, Gang, David R, Gang, David R., Marks, M. David, Soto-Fuentes, Wilfredo, Omburo, Stephanie N., Tian, Li, Omburo, Stephanie N, Wenger, Jonathan P., Weiblen, George D., He, Ji, Wenger, Jonathan P, Dixon, R. A., Dixon, Richard A, Marks, M David   +14 more
core   +1 more source

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source

Does Cannabis Use Contribute to Schizophrenia? A Causation Analysis Based on Epidemiological Evidence

Biomolecules
Cannabis abuse has been linked to acute psychotic symptoms as well as to the development of schizophrenia. Although the association has been well described, causation has not yet been investigated.
Sepehr Pourebrahim, Tooba Ahmad, Elisabeth Rottmann, Johannes Schulze, Bertram Scheller   +4 more
doaj   +1 more source

Ultrasonic or Microwave Modified Continuous Flow Chemistry for The Synthesis of Tetrahydrocannabinol: Observing Effects Of Various Solvents And Acids [PDF]

Synthesizing tetrahydrocannabinol is a lengthy process with minimal yields and little applicability on an industrial scale. To close the gap between bench chemistry and industry process chemistry, this paper introduces a small-scale flow chemistry method
Ivan, Cruces, Adam, Hellmann, Alex, Okhovat, Monica, Pittiglio, Westley, Cruces, Tesfay, Tesfatsion, Giovanni, Ramirez, Maite, Docampo-Palacios, Kyle, Ray   +8 more
core   +1 more source

Hemp Cultivation and Crop Diversification: Implications for Ecosystem Services in Kentucky

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study examines the ecosystem benefits of expanding hemp cultivation by assessing its impact on crop diversity. Using scenario‐based simulations and fixed‐effect panel regressions with county‐level data in Kentucky, we find that increased hemp acreage tends to enhance crop diversity, improving water quality and bird diversity.
Yunsun Park, Seong D. Yun, Brandy E. Phipps, Tyler Mark, Craig Schluttenhofer   +4 more
wiley   +1 more source

Are blood and oral fluid Δ9-tetrahydrocannabinol (THC) and metabolite concentrations related to impairment? A meta-regression analysis

, 2022
Blood and oral fluid Δ9-tetrahydrocannabinol (THC) concentrations are often used to identify cannabis-impaired drivers. We used meta-analytic techniques to characterise the relationships between biomarkers of cannabis use, subjective intoxication, and ...
Richard C. Kevin, McGregor, IS, Christopher Irwin, Iain S. McGregor, Kevin, RC, Thomas R. Arkell, Arkell, TR, Irwin, C, Danielle McCartney, McCartney, D   +9 more
core   +1 more source

Cannabis and Anxiety: A Critical Review

Medical Cannabis and Cannabinoids
Introduction: Cannabis has been reported to have both anxiogenic and anxiolytic effects. Habitual cannabis use has been associated with anxiety disorders (AD).
Alexander Beletsky, Cherry Liu, Bryson Lochte, Nebiyou Samuel, Igor Grant   +4 more
doaj   +1 more source