Results 51 to 60 of about 20,460 (225)

Dried blood spot analysis in antidoping: Technical challenges, analytical advances, and future perspectives

open access: yesBulletin of the Korean Chemical Society, EarlyView.
Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon   +4 more
wiley   +1 more source

Safety of cannabidiol products as a social issue: A case series

open access: yesAcute Medicine & Surgery
Background Cannabidiol (CBD) products have increased in popularity in Japan in recent years, particularly among young people. Some CBD products contain tetrahydrocannabinol (THC), the main ingredient of cannabis, and its analogs, which are illegal in ...
Yukari Maki   +5 more
doaj   +1 more source

Cannabinoid Activity—Is There a Causal Connection to Spasmolysis in Clinical Studies?

open access: yesBiomolecules, 2021
Cannabinoid drugs are registered for postoperative nausea and emesis, Tourette syndrome and tumor-related anorexia, but are also used for spasticity and pain relief, among other conditions.
Daniel Joseph, Johannes Schulze
doaj   +1 more source

(2‐Phosphinophenyl)aluminum Dichloride Complexes as Intramolecular Al/P Frustrated Lewis Pairs for Ketone, Ester, and Imine Activation

open access: yesChemistry – A European Journal, EarlyView.
Three 2‐phosphinophenylaluminum dichloride complexes were synthesized and characterized as novel intramolecular FLPs. These FLP systems exhibit high Lewis acidity and effectively activate challenging substrates including aliphatic ketones, imines, and esters. DFT analysis revealed that strain release and Al–P dynamics govern their reactivity. Abstract (
Yoshihiro Nishimoto   +2 more
wiley   +1 more source

Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials

open access: yesFrontiers in Pharmacology
OverviewCannabinoids have gained increasing attention for their therapeutic potential in treating several neurological conditions, including neurodegenerative diseases, chronic pain, and epilepsy.
Alqassem Y. Hakami   +2 more
doaj   +1 more source

Cannabis as a Source of Approved Drugs: A New Look at an Old Problem

open access: yesMolecules, 2023
Cannabis plants have been used in medicine since ancient times. They are well known for their anti-diabetic, anti-inflammatory, neuroprotective, anti-cancer, anti-oxidative, anti-microbial, anti-viral, and anti-fungal activities.
Adi Gabarin   +4 more
doaj   +1 more source

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

open access: yesChemistry – A European Journal, EarlyView.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke   +5 more
wiley   +1 more source

Prescription Practices of Cannabinoids in Children with Cerebral Palsy Worldwide—A Survey of the Swiss Cerebral Palsy Registry

open access: yesChildren, 2023
Cannabinoids are prescribed to children with cerebral palsy despite limited evidence. We aimed to assess cannabinoid prescribing practices in children with cerebral palsy, focusing on indications, types of preparations used, and tolerability. Furthermore,
Sandra Hunziker   +4 more
doaj   +1 more source

Is Delta-9-Tetrahydrocannabinol Estrogenic? [PDF]

open access: yesScience, 1977
Evidence is presented which indicates the lack of effect of delta-9-tetrahydrocannabinol or cannabis resin on tritiated estradiol-17beta binding to uterine cytosol receptor. The cannabinoids which demasculinize when given in vivo had no estrogneic properties as assessed by receptor studies on 2 different rodent species.
A B, Okey, G P, Bondy
openaire   +2 more sources

Chemical Straightening as a Source of Analytical Variability in Hair Testing: A Dual‐Analyte Case Report

open access: yesDrug Testing and Analysis, EarlyView.
ABSTRACT Hair analysis is increasingly used in forensic toxicology; however, result interpretation may be influenced by cosmetic hair treatments. Although the effects of bleaching, dyeing, and thermal straightening have already been evaluated, data on permanent chemical hair straightening are scarce, particularly under in vivo conditions.
Miriam Blanco‐Ces   +5 more
wiley   +1 more source

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