Results 71 to 80 of about 30,694 (295)

The total synthesis of some tetrahydrocannabinol metabolites

, 1980
An efficient synthesis of the metabolite 11-hydroxy-Δ8-tetrahydrocannabinol (2) has been developed, based on the one-carbon homologation of 11-nor-9-ketohexahydrocannabinol (69).
Guiver, Michael Dominic
core   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials

Frontiers in Pharmacology
OverviewCannabinoids have gained increasing attention for their therapeutic potential in treating several neurological conditions, including neurodegenerative diseases, chronic pain, and epilepsy.
Alqassem Y. Hakami, Alqassem Y. Hakami, Fahad S. Alshehri   +2 more
doaj   +1 more source

Computational and Comparative In Vitro Evaluation of GC-MS Profiled Cannabis sativa Inflorescence Extracts' Metabolites on Selected Diabetes Therapeutic Targets. [PDF]

Chem Biodivers
Cannabis sativa inflorescence extracts demonstrate promising antidiabetic potential through enzyme inhibition, antioxidant activity, and molecular docking. The hexane extract exhibits the strongest bioactivity, while key cannabinoids show high affinity for diabetes‐related targets, highlighting the plant as a promising source of novel antidiabetic ...
Chinheya RM, Ngoungoure VLN, Ali I, Olofinsan K, Jim T, Tankeu F, Matsabisa MG.   +6 more
europepmc   +2 more sources

Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration

, 2008
It was previously shown that haloperidol, but not clozapine, induced intense rat catalepsy when co-administered with delta-9-tetrahydrocannabinol.
Marchese, Giorgio, Casti, Paola, Ruiu, Stefania, Spada, Gabriele Pinna, Sanna, Angela, Casu, Gianluca, Pani, Luca   +6 more
core   +2 more sources

Cannabis and Autoimmunity: Possible Mechanisms of Action

ImmunoTargets and Therapy, 2021
Valeria Giorgi1 1, Daniela Marotto2 2, Alberto Batticciotto3 3, Fabiola Atzeni4 4, Sara Bongiovanni1 1, Piercarlo Sarzi-Puttini1 1 1Rheumatology Unit, Internal Medicine Department, ASST Fatebenefratelli-Sacco, Milan University School of Medicine, Milan ...
Giorgi V, Marotto D, Batticciotto A, Atzeni F, Bongiovanni S, Sarzi-Puttini P   +5 more
doaj  

Tetrahydrocannabinol (THC) cartridge ingestion

Journal of Pediatric Surgery Case Reports, 2020
We present the case of a 16-year-old male who ingested the tetrahydrocannabinol (THC) oil filled cartridge of a vape pen. With the recent increasing incidence of vaping related illnesses there is a significant focus on the hazards of the increasing use ...
Logan Meyer, Sathyaprasad Burjonrappa
doaj   +1 more source

Effects of Cannabidiol‐Rich Cannabis Oil on Facial Expression Recognition and Theory of Mind in Children With Autism Spectrum Disorder: A Randomized Clinical Trial

Autism Research, EarlyView.
ABSTRACT To evaluate, in a post hoc subanalysis, the effects of cannabidiol (CBD)‐rich cannabis oil on facial expression recognition and theory of mind in children with autism spectrum disorder (ASD). This post hoc subanalysis included children from a double‐blind, randomized, placebo‐controlled trial who completed social cognition assessments at ...
Wandersonia Moreira Brito Medeiros, Estácio Amaro da Silva Junior, Katy Lísias Gondim Dias de Albuquerque, Marine Diniz da Rosa, Amanda Gleiciane de Lima Oliveira, Maycon Jônatas da Silva, João Vitor Andrade Fernandes, Emily Caroline Costa Vieira, João Paulo Mendes dos Santos, Thais Cavalcanti Borges, Ana Hermínia Andrade e Silva, Carlos Espínola Neto Segundo, Nelson Torro‐Alves   +12 more
wiley   +1 more source

Synthesis of [13C4]-labeled ∆9-Tetrahydrocannabinol and 11-nor-9-Carboxy-∆9-tetrahydrocannabinol as Internal Standards for Reducing Ion Suppressing/Alteration Effects in LC/MS-MS Quantification [PDF]

, 2014
(−)-∆9-Tetrahydrocannabinol is the principal psychoactive component of the cannabis plant and also the active ingredient in some prescribed drugs. To detect and control misuse and monitor administration in clinical settings, reference samples of the ...
Bård Hoff, Morten Karlsen, Jon Eigill Johansen, Liu, Huiling, Bård Helge Hoff, Johansen, Jon Eigill, Karlsen, Morten, Hoff, Bård Helge, Huiling Liu, Jon Johansen   +9 more
core   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source