The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis [PDF]
Health Technology Assessment, 2015 Background: The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial aimed to determine whether or not oral Δ9-tetrahydrocannabinol (Δ9-THC) slowed the course of progressive multiple sclerosis (MS); evaluate safety of cannabinoid ...
Susan Ball +11 more
doaj +4 more sources
The Safety of Dronabinol and Nabilone: A Systematic Review and Meta-Analysis of Clinical Trials
Pharmaceuticals, 2022 Dronabinol, a natural cannabinoid, and its semi-synthetic derivative, nabilone, are marketed as medicines in several countries. The aim of our work was to systematically evaluate the frequency of adverse events related to dronabinol or nabilone treatment
Ákos Bajtel +2 more
exaly +3 more sources
Proof of Concept Trial of Dronabinol in Obstructive Sleep Apnea
Frontiers in Psychiatry, 2013 Study Objective: Animal data suggest that ∆9-TetraHydroCannabinol (∆9THC) stabilizes autonomic output during sleep, reduces spontaneous sleep-disordered breathing and blocks serotonin-induced exacerbation of sleep apnea.
Bharati Prasad, Michael E Ragozzino
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Reducing severe breathlessness with dronabinol in the group of patients with severe and very severe chronic obstructive pulmonary disease (BONG): a randomised, double-blinded, placebo-controlled, crossover study in an outpatient clinic in Denmark – a study protocol [PDF]
BMJ OpenIntroduction Cannabis-based medicine may alleviate breathlessness. This study will investigate whether dronabinol, a synthetic form of Δ9-tetrahydrocannabinol (Δ9-THC), reduces breathlessness in patients with severe and very severe chronic obstructive ...
Anders Løkke +5 more
doaj +2 more sources
A pilot study of dronabinol for the treatment of pain in sickle cell disease [PDF]
Pilot and Feasibility StudiesBackground Many adults living with sickle cell disease (SCD) suffer from chronic pain, turning to cannabis for relief. However, there are few studies that examine the efficacy of cannabis in treating pain associated with SCD.
Susanna A. Curtis +5 more
doaj +2 more sources
Bioavailability study of dronabinol oral solution versus dronabinol capsules in healthy volunteers
Clinical Pharmacology: Advances and Applications, 2016 Neha Parikh,1 William G Kramer,2 Varun Khurana,1 Christina Cognata Smith,1 Santosh Vetticaden,1 1INSYS Therapeutics, Inc., Chandler, AZ, USA; 2Kramer Consulting LLC, North Potomac, MD, USA Background: Dronabinol, a pharmaceutical Δ-9 ...
Parikh N +4 more
doaj +4 more sources
Dronabinol oral solution in the management of anorexia and weight loss in AIDS and cancer
Therapeutics and Clinical Risk Management, 2018 Melissa E Badowski, Paa Kwesi Yanful Section of Infectious Diseases Pharmacotherapy, Department of Pharmacy Practice, University of Illinois at Chicago, College of Pharmacy, Chicago, IL, USA Abstract: The true incidence of anorexia secondary to human ...
Melissa E Badowski
exaly +2 more sources
Investigating the effects of cannabinoids for the reduction of inflammation and sickle cell disease pain (CRISP); A protocol for a randomized double-blind placebo-controlled study. [PDF]
PLoS ONESickle Cell Disease (SCD) is a hemoglobinopathy affecting millions of people globally. Pain, both acute and chronic, affects over half of those living with SCD, but treatment of chronic pain is an ongoing challenge.
Jordan Bellis +8 more
doaj +2 more sources
Rastafarianism: When Religious Beliefs Conflict With Medical Necessity—A Case Report and Review of the Literature Around an Ethically Complicated Case [PDF]
Case Reports in PsychiatryDiscussion: This case exemplifies the complexities of clinical care when religious beliefs conflict with medical necessity. We discuss the limited indications for dronabinol and potential adverse effects on delirium’s behavioral symptoms.
Matthew Flick +2 more
doaj +2 more sources
Therapeutic Potential of Dronabinol: A Systematic Review of Human Trials [PDF]
Farmacja Polska, 2021 Dronabinol is an isomer of tetrahydrocannabinol that seems to have potential for both somatic and psychiatric disorders treatment. The purpose of this review is to provide an overview of collected articles with emphasis on the efficacy and safety of ...
Julia Lewandowska +2 more
doaj +1 more source