Results 1 to 10 of about 4,765 (162)

The Safety of Dronabinol and Nabilone: A Systematic Review and Meta-Analysis of Clinical Trials

Pharmaceuticals, 2022
Dronabinol, a natural cannabinoid, and its semi-synthetic derivative, nabilone, are marketed as medicines in several countries. The aim of our work was to systematically evaluate the frequency of adverse events related to dronabinol or nabilone treatment
Szabolcs Kiss, Balázs Csaba Nemeth, Judit Höhmann   +2 more
exaly   +3 more sources

Reducing severe breathlessness with dronabinol in the group of patients with severe and very severe chronic obstructive pulmonary disease (BONG): a randomised, double-blinded, placebo-controlled, crossover study in an outpatient clinic in Denmark – a study protocol [PDF]

BMJ Open
Introduction Cannabis-based medicine may alleviate breathlessness. This study will investigate whether dronabinol, a synthetic form of Δ9-tetrahydrocannabinol (Δ9-THC), reduces breathlessness in patients with severe and very severe chronic obstructive ...
Anders Løkke, Ole Hilberg, Ingeborg Farver-Vestergaard, Kristina Kock Hansen, Sofie Krogh Wolsing, Charlotte Uggerhøj Andersen   +5 more
doaj   +2 more sources

Proof of Concept Trial of Dronabinol in Obstructive Sleep Apnea

Frontiers in Psychiatry, 2013
Study Objective: Animal data suggest that ∆9-TetraHydroCannabinol (∆9THC) stabilizes autonomic output during sleep, reduces spontaneous sleep-disordered breathing and blocks serotonin-induced exacerbation of sleep apnea.
Bharati Prasad, David W Carley
exaly   +3 more sources

A pilot study of dronabinol for the treatment of pain in sickle cell disease [PDF]

Pilot and Feasibility Studies
Background Many adults living with sickle cell disease (SCD) suffer from chronic pain, turning to cannabis for relief. However, there are few studies that examine the efficacy of cannabis in treating pain associated with SCD.
Susanna A. Curtis, Ritika Jhawar, Jordan Bellis, Sarah McCuskee, Lesley Devine, John D. Roberts   +5 more
doaj   +2 more sources

Bioavailability study of dronabinol oral solution versus dronabinol capsules in healthy volunteers

Clinical Pharmacology: Advances and Applications, 2016
Neha Parikh,1 William G Kramer,2 Varun Khurana,1 Christina Cognata Smith,1 Santosh Vetticaden,1 1INSYS Therapeutics, Inc., Chandler, AZ, USA; 2Kramer Consulting LLC, North Potomac, MD, USA Background: Dronabinol, a pharmaceutical Δ-9 ...
Parikh N, Kramer WG, Khurana V, Cognata Smith C, Vetticaden S   +4 more
doaj   +5 more sources

Delta-9-Tetrahydrocannabinol (THC) Before Bedtime: Feasibility and Mechanistic Pilot Study on Sleep and Cardiac Autonomic Activity. [PDF]

J Sleep Res
ABSTRACT Disordered sleep is a common reason individuals report using cannabis, yet the physiological effects of Δ9‐tetrahydrocannabinol (Δ9‐THC) on sleep and autonomic regulation remain incompletely understood. Early studies reported acute sleep‐promoting effects of Δ9‐THC, but chronic use has been associated with disrupted sleep and possible ...
Gonzalez JE, Stewart AV, Ellison JL, Ordaz OH, Robinson LD, Clemons NA, Emens JS, Rice SPM, Shea SA, Bowles NP.   +9 more
europepmc   +2 more sources

Investigating the effects of cannabinoids for the reduction of inflammation and sickle cell disease pain (CRISP); A protocol for a randomized double-blind placebo-controlled study. [PDF]

PLoS ONE
Sickle Cell Disease (SCD) is a hemoglobinopathy affecting millions of people globally. Pain, both acute and chronic, affects over half of those living with SCD, but treatment of chronic pain is an ongoing challenge.
Jordan Bellis, Lydia Monk, Ritika Jhawar, Galia Pollock, Angela Liu, Charleen Jacobs-McFarlane, Brittany McCrary, Jeffrey Glassberg, Susanna Curtis   +8 more
doaj   +2 more sources

Dronabinol oral solution in the management of anorexia and weight loss in AIDS and cancer

Therapeutics and Clinical Risk Management, 2018
Melissa E Badowski, Paa Kwesi Yanful Section of Infectious Diseases Pharmacotherapy, Department of Pharmacy Practice, University of Illinois at Chicago, College of Pharmacy, Chicago, IL, USA Abstract: The true incidence of anorexia secondary to human ...

exaly   +2 more sources

Rastafarianism: When Religious Beliefs Conflict With Medical Necessity—A Case Report and Review of the Literature Around an Ethically Complicated Case [PDF]

Case Reports in Psychiatry
Discussion: This case exemplifies the complexities of clinical care when religious beliefs conflict with medical necessity. We discuss the limited indications for dronabinol and potential adverse effects on delirium’s behavioral symptoms.
Matthew Flick, Casey Martinez, David C. Fipps   +2 more
doaj   +2 more sources

A Scoping Review of Non-Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research. [PDF]

Clin Transl Sci
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Mills-Huffnagle SL, Lowden OM, Sullivan RE, McFadden TE, Nyland JE.   +4 more
europepmc   +2 more sources