Single oral administration of dronabinol increases ocular blood flow in patients with glaucoma. [PDF]
Acta OphthalmolAbstract Purpose Glaucoma is a leading cause of irreversible blindness globally, primarily driven by elevated intraocular pressure (IOP). Still, some patients progress despite significant IOP lowering, potentially due to impaired ocular blood flow. This study aimed to evaluate the effects of dronabinol, a synthetic tetrahydrocannabinol derivative, on ...
Lindner T +9 more
europepmc +2 more sources
Pronounced State-Level Disparities in Prescription of Cannabinoids to Medicaid Patients
Medical Cannabis and Cannabinoids, 2023 Introduction: Dronabinol is approved in the USA for chemotherapy-induced nausea as well as vomiting and HIV-induced anorexia, while cannabidiol is primarily approved for childhood epileptic disorders Lennox-Gastaut and Dravet syndrome.
Edward Y. Liu +2 more
doaj +1 more source
DMSO potentiates the suppressive effect of dronabinol on sleep apnea and REM sleep in rats
Journal of Cannabis Research, 2023 Introduction Dimethyl sulfoxide (DMSO) is an amphipathic molecule with innate biological activity that also is used to dissolve both polar and nonpolar compounds in preclinical and clinical studies.
Michael W. Calik, David W. Carley
doaj +1 more source
Palliative Medicine Reports, 2023 Background: Cannabis may offer therapeutic benefits to patients with advanced cancer not responding adequately to conventional palliative treatment. However, tolerability is a major concern.
Ditte Buchwald +8 more
doaj +1 more source
Matched pilot study examining cannabis-based dronabinol for acute pain following traumatic injury
Trauma Surgery & Acute Care Open, 2020 Background To determine whether adjunctive dronabinol, a licensed form of delta-9-tetrahydrocannabinol, reduces opioid consumption when used off-label for managing acute pain following traumatic injury.Methods This matched cohort study included patients ...
Kristin Salottolo +5 more
doaj +1 more source
Brain Sciences, 2020 Delta-9-tetrahydrocannabinol (Δ9-THC) and other cannabinoids present in cannabis (marijuana) have been shown to affect the normal inhibitory pathways that influence nociception in humans.
Claire Swartwood +3 more
doaj +1 more source
Caracterización de la problemática del uso terapéutico del Aceite de Cannabis en Córdoba, Argentina
Revista de la Facultad de Ciencias Médicas de Córdoba, 2022 El uso terapéutico del aceite de “cannabis” es una problemática social que pone en tensión aspectos legales, sanitarios, científicos y culturales. La dificultad en el acceso genera un vacío aprovechado por el mercado ilegal, al que recurren pacientes y ...
Pablo Gabriel Manzo +9 more
doaj +1 more source
Cannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats. [PDF]
PLoS ONE, 2014 The prevalence of obstructive sleep apnea (OSA) in Americans is 9% and increasing. Increased afferent vagal activation may predispose to OSA by reducing upper airway muscle activation/patency and disrupting respiratory rhythmogenesis.
Michael W Calik, David W Carley
doaj +1 more source
Phytocannabinoids as novel therapeutic agents in CNS disorders [PDF]
, 2012 The Cannabis sativa herb contains over 100 phytocannabinoid (pCB) compounds and has been used for thousands of years for both recreational and medicinal purposes.
Hill, Andrew J. +3 more
core +1 more source
Pancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]
, 2014 Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.
Andrew Eugene Hendifar +8 more
core +2 more sources