Results 31 to 40 of about 5,604 (187)

Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia

EBioMedicine, 2020
Background: Overriding the differentiation blockage in acute myeloid leukemia (AML) is the most successful mode-of-action in leukemia therapy – now curing the vast majority of patients with acute promyelocytic leukemia (APL) using all-trans retinoic acid
K.M. Kampa-Schittenhelm, T. Haverkamp, M. Bonin, V. Tsintari, H.J. Bühring, L. Haeusser, G. Blumenstock, S.T. Dreher, T. Ganief, F. Akmut, B. Illing, U.A. Mau-Holzmann, I. Bonzheim, E. Schleicher, W. Vogel, M.M. Schittenhelm   +15 more
doaj   +1 more source

Cannabinoids in hyperhidrosis

Journal of Dermatological Treatment, 2023
Hyperhidrosis can significantly curtail patient quality of life, from debilitating physical symptoms to social stigmatization and reduced life opportunities.
Till Kaemmerer, Benjamin Maximilian Clanner-Engelshofen, Tony Lesmeister, Lars Einar French, Markus Reinholz   +4 more
doaj   +1 more source

Cannabis therapy in neurological disorders: Recent advances and perspectives [PDF]

Romanian Journal of Pharmaceutical Practice, 2020
Both phytocannabinoids (Δ9-tetrahydrocannabinol, cannabidiol) and synthetic derivatives (nabilone, dronabinol) showed therapeutic benefits in some neurological disorders.
Alexandru Mandici, Daniel Cojocariu, Anca Miron   +2 more
doaj   +1 more source

Grinding and Fractionation during Distillation Alter Hemp Essential Oil Profile and Its Antimicrobial Activity

Molecules, 2020
The hypothesis of this study was that we can modify the essential oil (EO) profile of hemp (Cannabis sativa L.) and obtain fractions with differential composition and antimicrobial activity.
Valtcho D. Zheljazkov, Vladimir Sikora, Ivanka B. Semerdjieva, Miroslava Kačániová, Tess Astatkie, Ivayla Dincheva   +5 more
doaj   +1 more source

Case Report: Secondary bilateral parkinsonism and dystonia treated with dronabinol [version 3; peer review: 2 approved]

F1000Research, 2021
Drug abuse may damage basal ganglia that are essential for planning and execution of movements. We report about the case of a 38-year old patient with ischemic lesions of the basal ganglia presenting with bilateral painful dystonia and parkinsonism ...
Natalia Szejko, Florian Burger, Victoria Sidoroff, Gregor K. Wenning   +3 more
doaj   +1 more source

Cannabinoids in the Treatment of Cannabis Use Disorder: Systematic Review of Randomized Controlled Trials

Frontiers in Psychiatry, 2022
BackgroundThe prevalence of cannabis use and cannabis use disorders (CUD) has significantly increased over time. However, there are no approved pharmacological treatments for CUD.
Caroline Vuilleumier, Norbert Scherbaum, Udo Bonnet, Udo Bonnet, Patrik Roser, Patrik Roser   +5 more
doaj   +1 more source

Industrial, CBD, and Wild Hemp: How Different Are Their Essential Oil Profile and Antimicrobial Activity?

Molecules, 2020
Hemp (Cannabis sativa L.) is currently one of the most controversial and promising crops. This study compared nine wild hemp (C. sativa spp. spontanea V.) accessions with 13 registered cultivars, eight breeding lines, and one cannabidiol (CBD) hemp ...
Valtcho D. Zheljazkov, Vladimir Sikora, Ivayla Dincheva, Miroslava Kačániová, Tess Astatkie, Ivanka B. Semerdjieva, Dragana Latkovic   +6 more
doaj   +1 more source

Identification of Potential Distinguishing Markers for the Use of Cannabis-Based Medicines or Street Cannabis in Serum Samples

Metabolites, 2021
Increasing prescription numbers of cannabis-based medicines raise the question of whether uptake of these medicines can be distinguished from recreational cannabis use. In this pilot study, serum cannabinoid profiles after use of cannabis-based medicines
Anne Scheunemann, Katrin Elsner, Tanja Germerott, Sergiu Groppa, Cornelius Hess, Isabelle Miederer, Alicia Poplawski, Jörg Röhrich   +7 more
doaj   +1 more source

Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial. [PDF]

, 2013
Laboratory evidence has shown that cannabinoids might have a neuroprotective action. We investigated whether oral dronabinol (Δ(9)-tetrahydrocannabinol) might slow the course of progressive multiple ...
Hobart, Jeremy, Vickery, J, CUPID investigator group, Wright, D, Vickery, Jane, Ball, S, Mallik, S, Miller, D, Gomez Cano, Mayam, Zajicek, J, Hobart, J, Nunn, A, Miller, David, Wright, David, Mallik, Sharukh, McManus, D, ?, ?, McManus, David, Gomez Cano, M, Ball, Susan, Zajicek, John, Nunn, Andrew   +21 more
core   +1 more source

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source