Efficacy and safety of cannabinoids in the treatment of spasticity in multiple sclerosis: A systematic review of randomized clinical trials. [PDF]
Br J Clin PharmacolAims This work aimed to evaluate the efficacy and safety of cannabinoids for the treatment of MS‐related spasticity. Methods Systematic searches were conducted in PubMed, EMBASE, and LILACS on 2 December 2025. Randomized controlled trials evaluating natural or synthetic cannabinoids for MS‐related spasticity were included.
Hamm-Buiar L +3 more
europepmc +2 more sources
Bedtime tetrahydrocannabinol ingestion reduces morning orthostatic cardiovascular reactivity in adults: An exploratory study. [PDF]
Physiol RepAbstract Acute cannabis use and its primary psychoactive constituent tetrahydrocannabinol (THC) can induce postural dizziness, indicating increased risk of orthostatic instability. However, it is unknown if vulnerabilities persist the morning after bedtime THC consumption.
Gonzalez JE +8 more
europepmc +2 more sources
Proof-of-concept trial of PP-01 for mitigating cannabis withdrawal syndrome in participants with cannabis use disorder. [PDF]
Am J AddictAbstract Background and Objectives Cannabis withdrawal symptoms can be severe and protracted, significantly impeding the ability to abstain from cannabis use, resulting in failed quit attempts and relapse. This clinical trial evaluated safety and efficacy of PP‐01, a novel dual‑mechanism of action, investigational agent, for mitigating cannabis ...
Slagle AF +4 more
europepmc +2 more sources
Matched pilot study examining cannabis-based dronabinol for acute pain following traumatic injury
Trauma Surgery & Acute Care Open, 2020 Background To determine whether adjunctive dronabinol, a licensed form of delta-9-tetrahydrocannabinol, reduces opioid consumption when used off-label for managing acute pain following traumatic injury.Methods This matched cohort study included patients ...
Kristin Salottolo +5 more
doaj +1 more source
Caracterización de la problemática del uso terapéutico del Aceite de Cannabis en Córdoba, Argentina
Revista de la Facultad de Ciencias Médicas de Córdoba, 2022 El uso terapéutico del aceite de “cannabis” es una problemática social que pone en tensión aspectos legales, sanitarios, científicos y culturales. La dificultad en el acceso genera un vacío aprovechado por el mercado ilegal, al que recurren pacientes y ...
Pablo Gabriel Manzo +9 more
doaj +1 more source
Dronabinol as an answer to flavivirus infections: an in-silico investigation
, 2022 Flavivirus infections are common in several parts of the world. Two major types of flaviviruses are dengue and zika viruses. Both these two viral infections have caused many fatalities around the world.
Abani Kumar Patar (14306686) +4 more
core +1 more source
Acetylcholinesterase Inhibitory Activity of Standardized Cannabinoids-rich Fractions [PDF]
Pharmaceutical and Biomedical Research, 2023 Background: Since cannabis has been legally allowed for medicinal purposes in many countries, it has become the most interesting issue, particularly in neurologic disorders, such as Alzheimer’s disease (AD).
Wiwit Suttithumsatid +4 more
doaj
Unexpected improvement of hyperhidrosis with cannabidiol [PDF]
Einstein (São Paulo), 2022 Hyperhidrosis is characterized by excessive sweating and it affects almost 5% of the population. The affected age group is wide, and it can affect from children to elderlies. There are two types of hyperhidrosis: generalized and focal.
Rubens Pitliuk +2 more
doaj +1 more source
Cannabinoids in treatment of obstructive sleep apnea syndrome
Medycyna Ogólna i Nauki o Zdrowiu, 2022 Introduction and objective Obstructive sleep apnea syndrome (OSAS) is becoming increasingly more prevalent in the general population. Its negative impact on the cardiovascular system and patients’ non-compliance to validated treatment options is a ...
Paulina Maria Szot, Antoni Krzeski
doaj +1 more source